Immunocytochemical analysis of oestrogen receptors and progesterone receptors in the human uterus throughout the menstrual cycle and after the menopause

Snijders, Marc P.L.M.; Goeij, A.F.P.M. De; Baerts, M. J. C. Debets-Te; Rousch, Mat; Koudstaal, J; Bosman, Fred T.

doi:10.1016/0020-7292(92)90290-y

Cited by 60 publications

(83 citation statements)

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“…These findings are similar to those observed in the inactive endometria of menopausal cynomolgus monkeys in our study. In studies that included material from postmenopausal women, high levels of estrogen receptor expression were observed (Scharl et al 1988;Snijders et al 1992). Comparable results were observed in aged cynomolgus monkeys .…”

Section: The Progesterone Receptormentioning

confidence: 83%

“…Comparable results were observed in aged cynomolgus monkeys . Although less pronounced, progesterone receptors also persist in the endometrium of postmenopausal women (Snijders et al 1992). …”

Section: The Progesterone Receptormentioning

confidence: 99%

“…Some investigators, who reported on glandular estrogen receptor expression in the human endometrium during the normal menstrual cycle, noted a gradual decrease of such receptors during the luteal phase (Koshiyama et al 1995;Lessey et al 1988;Snijders et al 1992;Vollmer et al 1990). This finding is in accordance with the above mentioned description, since in this phase of the cycle there is progesterone dominance.…”

Section: Comparisons To the Human Endometriummentioning

confidence: 99%

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The Macaque Endometrium, with Special Reference to the Cynomolgus Monkey (Macaca fascicularis)

Esch¹,

Cline²,

Buse³

et al. 2008

Toxicol Pathol

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The macaque endometrium undergoes dramatic morphologic and functional changes during the menstrual cycle that are nearly identical to those of the human endometrium. The sequential events that take place in the endometrium are mainly driven by the ovarian steroids and their respective receptors. To be able to interpret the changes and effects induced by mammalian or synthetic hormones and other compounds that could have influence on the hormonal status of the animal, a thorough knowledge of the anatomy, physiology, and histology of the cyclic hormone-mediated processes within the endometrium is indispensable. In this paper we give an overview of uterine growth and development, anatomy, basic histology, aging, spontaneous pathology, and the techniques to study the endometrium in-life. In addtion, a comprehensive description of the receptor-mediated, hormonedriven morphological changes during the menstrual cycle in the cynomolgus monkey (Macaca fascicularis) is given. Where possible, differences between the macaque and human endometria are discussed.Keywords: female reproduction; endometrium; histology; menstrual cycle; hormone receptors; endometrial dating; cynomolgus monkey.human. For this reason, monkey species belonging to this group are preferred as experimental models in studies of human reproduction, pharmacology, and toxicology. Especially for studies with sex hormones, synthetic steroidal compounds or compounds that interfere with the hypothalamus-pituitary-ovarian (or testicular) axis, such monkey species are predictive . The rhesus monkey (Macaca mulatta) and the cynomolgus monkey (Macaca fascicularis) are the species most often used for these purposes. In our laboratories, purpose-bred cynomolgus monkeys are used for such studies. Besides their resemblance in menstrual cycle physiology, these monkeys are relatively small and easy to handle.Both the human and the macaque monkey endometria undergo dramatic morphologic and functional changes during the menstrual cycle. The sequential events that take place in the endometrium are mainly driven by the ovarian steroids estradiol and progesterone and their respective receptors.To be able to interpret the changes and effects induced by mammalian or synthetic hormones and other compounds that could have influence on the hormonal status of the animal, or that interfere with the regulatory processes within the endometrium, a thorough knowledge of the anatomy, physiology, and histology of cyclic hormone-mediated processes within the endometrium is indispensable.In this paper we give a brief overview of endometrial growth and development, anatomy, basic histology, and the effects of aging, and we briefly discuss the spontaneous pathology of the endometrium of macaques. The receptor-mediated,

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Section: The Progesterone Receptormentioning

confidence: 83%

Section: The Progesterone Receptormentioning

confidence: 99%

Section: Comparisons To the Human Endometriummentioning

confidence: 99%

See 1 more Smart Citation

The Macaque Endometrium, with Special Reference to the Cynomolgus Monkey (Macaca fascicularis)

Esch¹,

Cline²,

Buse³

et al. 2008

Toxicol Pathol

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“…One conserved function of steroid hormone receptors is that they autoregulate the expression of their own genes (Schmidt and Meyer, 1994). Estrogens upregulate ERa gene expression in uteri of all mammalian species examined, including rodents (Bergman et al, 1992) primates (Hild-Petito et al, 1992;Koji and Brenner, 1993) and humans (Lessey et al, 1988;Snijders et al, 1992). Thus, expression of ERa is increased after its binding to estradiol, resulting in a positive feedback mechanism that controls transcription of ERa.…”

Section: Discussionmentioning

confidence: 99%

ERα-mediated repression of pro-inflammatory cytokine expression by glucocorticoids reveals a critical role for TNFα and IL1α in lumen formation and maintenance.

Eritja

Mirantes

Llobet

et al. 2012

Journal of Cell Science

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SummaryMost glandular tissues comprise polarized epithelial cells organized around a single central lumen. Although there is active research investigating the molecular networks involved in the regulation of lumenogenesis, little is known about the extracellular factors that influence lumen formation and maintenance. Using a three-dimensional culture system of epithelial endometrial cells, we have revealed a new role for pro-inflammatory cytokines such as TNFa and IL1a in the formation and, more importantly, maintenance of a single central lumen. We also studied the mechanism by which glucocorticoids repress TNFa and IL1a expression. Interestingly, regulation of pro-inflammatory cytokine expression and subsequent lumen formation is mediated by estrogen receptor a (ERa) but not by the glucocorticoid receptor. Finally, we investigated the signaling pathways involved in the regulation of lumen formation by proinflammatory cytokines. Our results demonstrate that activation of the ERK/MAPK signaling pathway, but not the PI3K/Akt signaling pathway, is important for the formation and maintenance of a single central lumen. In summary, our results suggest a novel role for ERaregulated pro-inflammatory cytokine expression in lumen formation and maintenance.

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“…Both PR-A and PR-B also increase during the follicular phase probably under the influence of estrogen and decreases in the epithelium in the luteal phase, but it stays at a higher level in the stroma (predominant isoform-PRA) until menstruation [13][14][15].…”

Section: Er and Pr Receptors And Their Functionsmentioning

confidence: 99%

The Estrogen and Progesterone Receptors in Endometrial Carcinoma - An Update

Dasgupta¹

2017

EMIJ

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Immunohistochemistry of estrogen (ER) and progesterone (PR) receptors in breast cancer is an established method of predicting responsiveness to hormonal treatment and calculating the prognosis and disease free survival rates. However the utility of immunohistochemistry of ER and PR in endometrial cancer (EC), another hormone dependent neoplasia has not yet been well defined and is not a routine in treatment algorithms. Their changing levels in various stages of menstrual cycle and action by alteration of genes regulating endometrial cell cycle have been extensively studied. This knowledge is gradually being integrated in selection of management protocols in terms of initial risk stratification and selection of hormonal and or cytotoxic agents as primary treatment modality or as adjuvants following surgery. This review looks into the molecular basis of ER and PR receptor alterations in EC together with its clinical implications.

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Immunocytochemical analysis of oestrogen receptors and progesterone receptors in the human uterus throughout the menstrual cycle and after the menopause

Cited by 60 publications

References 0 publications

The Macaque Endometrium, with Special Reference to the Cynomolgus Monkey (Macaca fascicularis)

The Macaque Endometrium, with Special Reference to the Cynomolgus Monkey (Macaca fascicularis)

ERα-mediated repression of pro-inflammatory cytokine expression by glucocorticoids reveals a critical role for TNFα and IL1α in lumen formation and maintenance.

The Estrogen and Progesterone Receptors in Endometrial Carcinoma - An Update

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