Immunogenetic and nutritional profile in insulin-using youth-onset diabetics in Korea

Role of islet autoimmunity in the aetiology of different clinical subtypes of diabetes mellitus in young north Indians

“…While Huh et al . (1992) detected ICA in 50% of their 22 Korean subjects[9], Taniguchi et al . (1989) could demonstrate ICA in only one of 24 Indonesian patients[12].…”

“…(1989) could demonstrate ICA in only one of 24 Indonesian patients[12]. Some investigators have reported that MMDM subjects have HLA–DR antigen associations similar to Type 1 DM[9–13]. In contrast, Sanjeevi et al .…”

“…In view of the close clinical similarity with Type 1 DM, and reports that some MMDM patients may become ketosis‐prone after nutritional rehabilitation[8], others believe that it may have an autoimmune aetiology. The available data on the association with HLA class II antigens and prevalence of cytoplasmic islet cell antibodies (ICA) are contradictory[9–14]. Data on antibodies against the islet antigens glutamic acid decarboxylase (GADA) and tyrosine phosphatase (IA‐2 A) may provide further information[15], but are not available.…”

Clinical characteristics of Korean type 2 diabetic patients in 2005

“…In Korea, the prevalence of diabetes rose from 1% of general population in the 1970s to approximately 3% in the late 1980s. In 2000, 13.5% of males and 10.7% of females 30 years or older had diabetes; among these, 95% were type 2 diabetics [1,2]. Although it may vary according to region, the prevalence of diabetes in Korea is now comparable to that of developed countries, ranging from 7 to 12% of general population [3].…”

Clinical characteristics, GAD antibody (GADA) and change of C‐peptide in Korean young age of onset diabetic patients

“…The ‘high→low’ subgroup had a higher incidence of ketonuria and a lower BMI at follow‐up than the subgroups ‘high→high’ and ‘high→intermediate’. These findings suggested the presence of insulin deficiency at the time of the initial diagnosis [7,26].…”