Immunogenetic Studies of Species Relationships

Comments on the early history of immunogenetics12

“…The general conclusions that were reached from these studies of species relationships were stated relatively early in the experiments (Irwin, 1938), as follows: 'The experiments and references presented in this and in preceding papers (loc. cit.)…”

Allo-Antigens and Antigenic Factors of Human Leukocytes

“…As far as it is possible to consider interspecies relationships as being the most complex, Irwin and Cumley [3] proved that this situation can be also ex plained on the basis of a rather limited number of antigens segregat ing in hybrids, at least in the species of the birds studied. An example of a simplex-complex explanation is the CDE/cde classification of Rh.…”

Allo‐Antigens and Antigenic Factors of Human Leukocytes: A Hypothesis

“…A typical example of what could be called a complex-simplex explanation was given by LANDSTEINER and LEVINE [4] in their interpretation of the complex situation of cattle blood group systems and by WIENER [6] for chicken blood group systems. As far as it is possible to consider interspecies relationships as being the most complex, IRWIN and CUMLEY [3] proved that this situation can be also explained on the basis of a rather limited number of antigens segregating in hybrids, a t least in the species of the birds studied. An example of a simplex-complex explanation is the CDE/cde classification of Rh.…”

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Recently HIRSCHFELD [Z]pointed out that the method of classification affects drastically the interpretation of immunogenetic systems.A typical example of what could be called a complex-simplex explanation was given by LANDSTEINER and LEVINE [4] in their interpretation of the complex situation of cattle blood group systems and by WIENER [6] for chicken blood group systems. As far as it is possible to consider interspecies relationships as being the most complex, IRWIN and CUMLEY [3] proved that this situation can be also explained on the basis of a rather limited number of antigens segregating in hybrids, a t least in the species of the birds studied. An example of a simplex-complex explanation is the CDE/cde classification of Rh.Absorption experiments have shown that practically all hyperimmune chicken and cattle (anti-erythrocyte) sera are polyvalent, but some anti-Rh sera are monovalent or a t least relatively pure.

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