Immunogenicity and efficacy of an in-house developed cell-culture derived veterinarian rabies vaccine

Kallel, Héla; Diouani, Mohamed Fethi; Loukil, Houssem; Trabelsi, Khaled; Snoussi, Mohamed Ali; Majoul, Samy; Rourou, Samia; Dellagi, Koussay

doi:10.1016/j.vaccine.2006.03.012

Cited by 16 publications

(18 citation statements)

References 17 publications

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“…This data is in line to those reported by [14,15] in which all dogs challenged with rabies street virus of canine origin, survived in the group of vaccinated dogs and 80% of control dogs succumbed to the virus challenge. The finding of this study demonstrates the immunogenicity and protectivity of candidate vaccine.…”

Section: Virus Challengesupporting

confidence: 92%

Antibody Response of Dogs to Ethiorab Rabies Vaccine

Hurisa¹

2015

IJVV

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Rabies is 100% fatal, but it is preventable. More than 95% of human rabies cases occur in improperly treated individuals. This is partly due to the fact that modern post-exposure rabies prophylaxis is expensive and therefore not readily available in many endemic regions. Nervous tissue vaccine has been in use for more than 100 yrs. These vaccines have now been superseded in purity, potency, immunogenicity and safety. The efficacy and immunogenicity of inactivated tissue culture vaccine, produced in Ethiopia was evaluated. Twelve experimental dogs from local breed were duly conditioned during a quarantine period and assigned to two groups randomly. Animals in group I (cases) were vaccinated subcutaneously with 1 ml of our experimental vaccine. Dogs in group II served as non-vaccinated controls. The immune response of each dog was monitored for 120 days. On the day 120 after final sampling, all dogs were challenged in the masseter muscle with a rabies street virus of canine origin. To evaluate the titer of the rabies virus neutralizing antibodies (VNA), sera were analyzed by Fluorescent Antibody Virus Neutralization (FAVN) Test. Geometric Mean Titers (GMT) to rabies virus was determined at days 7

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Section: Virus Challengesupporting

confidence: 92%

Antibody Response of Dogs to Ethiorab Rabies Vaccine

Hurisa¹

2015

IJVV

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“…Fifteen days after the administration of the vaccine the rabies antibodies response showed an increase of mean titer of VNA, the mean titer was 1.7 IU/ml ( Figure 2). The result obtained at day 15 was lower than those reported by Kallel et al [18] in which the rabies virus neutralization antibody was 6.1 IU/ml at day 15. At 21 days post-vaccination, all vaccinated animals except one dog showed titer increase (Figure 3).…”

Section: Antibody Responses Of Dogscontrasting

confidence: 76%

“…Seven days after vaccine administration the GMT of virus neutralizing antibody was 1.55 IU/ml (Figure 1). This result is better than those reported by Kallel et al [18], in which the rabies antibody sera responded after 7 days.…”

Section: Antibody Responses Of Dogscontrasting

confidence: 72%

Safety and Immunogenicity of ETHIORAB Rabies Vaccine

Tegbaru¹,

Mengesha²

2013

J Vaccines Vaccin

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Worldwide rabies in dogs is the source of 99% of human infections. This makes dogs potential reservoir and transmitters to human being. Pre and post-exposure prophylaxis are means of protection against the rabies virus. The main objective of this experiment was to determine the safety and immunogenicity of Vero cell culture based rabies vaccine "ETHIORAB" manufactured by Ethiopian Health and Nutrition Research Institute, Vaccine and Diagnostic Production Directorate. The obtained vaccine was tested on mice and satisfactory safety results were observed. Random Clinical Trial (RCT) design was used for this experiment. Twelve experimental dogs from local breed were duly conditioned during a quarantine period and assigned to two groups randomly. Group I (cases) were vaccinated subcutaneously with 1 ml of ETHIORAB. Dogs in group II served as non-vaccinated controls. To evaluate the titer of the rabies virus neutralizing antibodies (VNA), sera were analyzed by Fluorescent Antibody Virus Neutralization (FAVN) test. Serum neutralizing antibody geomtric mean titers (GMT) to rabies virus was determined at days 7, 15, 21, 30, 60 and 90. Geomtric mean titers were equal to 1.55, 1.73, 2.02, 3.45, 3.57 and 3.17 IU/ml respectively. All dogs showed VNA titers higher than the 0.5 IU/ml mandated WHO recommended threshold. This study indicated ETHIORAB rabies vaccine manufactured in Ethiopia is safe and immunogenic.

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“…Therefore, P NP was calculated based on this cut-off using the method described in Goddard et al [4] which combines the data of four vaccination studies [12,13,14,15]. Three rabies vaccines, Rabisin (Rb), Madivak (Md) and Nobivak (Nb), were considered and P NP was given by:…”

Section: Probability That An Unprotected Animal Passes the Neutralizimentioning

confidence: 99%

Quantitative risk assessment of the introduction of rabies into Japan through the importation of dogs and cats worldwide

et al. 2017

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SUMMARYJapan has been free from rabies since 1958. A strict import regimen has been adopted since 2004 consisting of identification of an animal with microchip, two-time rabies vaccination, neutralizing antibody titration test and a waiting period of 180 days. The present study aims to quantitatively assess the risk of rabies introduction into Japan through the international importation of dogs and cats and hence provide evidence-based recommendations to strengthen the current rabies prevention system. A stochastic scenario tree model was developed and simulations were run using @RISK. The probability of infection in a single dog or cat imported into Japan is estimated to be 2·16 × 10−9 [90% prediction interval (PI) 6·65 × 10−11–6·48 × 10−9]. The number of years until the introduction of a rabies case is estimated to be 49 444 (90% PI 19 170–94 641) years. The current import regimen is effective in maintaining the very low risk of rabies introduction into Japan and responding to future changes including increases in import level and rabies prevalence in the world. However, non-compliance or smuggling activities could substantially increase the risk of rabies introduction. Therefore, policy amendment which could promote compliance is highly recommended. Scenario analysis demonstrated that the waiting period could be reduced to 90 days and the requirement for vaccination could be reduced to a single vaccination, but serological testing should not be stopped.

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Immunogenicity and efficacy of an in-house developed cell-culture derived veterinarian rabies vaccine

Cited by 16 publications

References 17 publications

Antibody Response of Dogs to Ethiorab Rabies Vaccine

Antibody Response of Dogs to Ethiorab Rabies Vaccine

Safety and Immunogenicity of ETHIORAB Rabies Vaccine

Quantitative risk assessment of the introduction of rabies into Japan through the importation of dogs and cats worldwide

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