Immunoglobulin-bearing cells in giardiasis.

Thompson, Alfred L.; Rowland, R.; Hecker, Robert; Gibson, G. E.; Reid, D P

doi:10.1136/jcp.30.3.292

Cited by 19 publications

(6 citation statements)

References 5 publications

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“…In contrast, the establishment phase of G. lamblia infection in the IEL, LPL as well as PP of the infected mice was accompanied by proliferation of IgM‐bearing cells (Tables 1 and 2 respectively) suggesting that during the early stage of G. lamblia infection the immunoglobulin production was predominantly of the IgM isotype. This observation agrees well with the earlier reports in human giardiasis [39–41]. The proliferation of IgM‐bearing cells during the acute phase of the disease is not affected by the feedback suppressor pathway as the initial differentiation of pre‐B cells to immune IgM‐bearing cells is independent of T cells or lymphokines [42].…”

Section: Resultssupporting

confidence: 92%

Immune effector responses to an excretory-secretory product ofGiardia lamblia

Kaur

Samra

Ghosh

et al. 1999

FEMS Immunology &Amp; Medical Microbiology

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The prior immunisation of mice with purified excretory-secretory product (ESP) led to a complete failure of Giardia lamblia colonisation following challenge inoculation of these animals with trophozoites. The prior immunisation of mice with ESP resulted in a significant stimulation of local immunity as evidenced by a significant enhancement of T helper/inducer activity along with a significant increase in immunoglobulin A-bearing cells. Further, the presence of anti-ESP antibodies in the serum of immunised as well as immunised-challenged animals indicated the stimulation of the systemic lymphoid system. This suggests that the ESP is highly immunogenic and it could be one of the major antigens of G. lamblia responsible for protection against the infection.

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Section: Resultssupporting

confidence: 92%

Immune effector responses to an excretory-secretory product ofGiardia lamblia

Kaur

Samra

Ghosh

et al. 1999

FEMS Immunology &Amp; Medical Microbiology

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“…The frequency and degree of mucosal injury varies from series to series. Tewari and Tandon [24] found mild cellular changes under light microscopy but no evidence of villous atrophy [20][21][22][23][25][26][27][28][29]. Various amounts of inflammatory infiltration also accompany the villous shortening [19,20,23,25].…”

Section: Morphological Changes In the Intestinal Mucosamentioning

confidence: 98%

Giardiasis: Nutritional Implications

Solomons¹

1982

Clinical Infectious Diseases

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The debate about the pathogenicity of Giardia lamblia in man has ended, and the issues regarding the prevalence of clinical and subclinical infections and their nutritional impact have become the foremost considerations. Giardiasis can produce steatorrhea, maldigestion, and malabsorption of carbohydrates and of vitamins A and B 12 • The mechanisms of the absorptive dysfunction are not clear, but morphological abnormalities of the intestinal mucosa and/or bacterial overgrowth might playa role. Severe clinical giardiasis can cause "failure to thrive" in young children, but the impact, if any, of subclinical giardiasis on growth in general populations is not well defined. Proteinenergy malnutrition appears to predispose to giardial infection, perhaps because of the accompanying hypochlorhydria, immunosuppression, and altered gastrointestinal flora. The lack of a sensitive and noninvasive diagnostic test for human giardial infection limits the investigation of the nutritional correlates of giardiasis.

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“…There is however, some controversy as to which immunoglobulin classes are involved. Early studies suggested that IgM cells were increased but that IgA cells were either reduced, unchanged or increased (57–60). More recently, when all five immunoglobulin classes have been studied at the same time, IgA and IgM cell numbers were similar to controls during infection, but IgA cells increased following successful eradication (61).…”

Section: Gut Immunopathology In the Immunocompetent Hostmentioning

confidence: 99%

Immune response‐mediated pathology in human intestinal parasitic infection

Farthing

2003

Parasite Immunology

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Immunoglobulin-bearing cells in giardiasis.

Cited by 19 publications

References 5 publications

Immune effector responses to an excretory-secretory product ofGiardia lamblia

Immune effector responses to an excretory-secretory product ofGiardia lamblia

Giardiasis: Nutritional Implications

Immune response‐mediated pathology in human intestinal parasitic infection

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