Immunoglobulin Prophylaxis against Milkborne Transmission of Human T Cell Leukemia Virus Type I in Rabbits

Sawada, Takashi; Iwahara, Yoshihito; Ishii, Kazuyoshi; Taguchi, Hirokuni; Hoshino, Hiroo; Miyoshi, Isao

doi:10.1093/infdis/164.6.1193

Cited by 55 publications

(25 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…blood, semen, milk) for the virus infection Uemura et al, 1986Uemura et al, , 1987Hirose et al, 1988;Iwahara et al, 1990;Kataoka et al, 1990). Pioneering studies utilizing the rabbit model of HTLV-1 have provided important clues as to the number of cells capable of transmitting the virus infection and effective means to prevent the transmission of the virus (Takehara et al, 1989;Kataoka et al, 1990;Sawada et al, 1991;Miyoshi et al, 1992;Tanaka et al, 1994).…”

Section: Rabbit Modelsmentioning

confidence: 99%

Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

2005

View full text Add to dashboard Cite

Over the past 25 years, animal models of human T-lymphotropic virus type 1 (HTLV-1) infection and transformation have provided critical knowledge about viral and host factors in adult T-cell leukemia/lymphoma (ATL). The virus consistently infects rabbits, some non-human primates, and to a lesser extent rats. In addition to providing fundamental concepts in viral transmission and immune responses against HTLV-1 infection, these models have provided new information about the role of viral proteins in carcinogenesis. Mice and rats, in particular immunodeficient strains, are useful models to assess immunologic parameters mediating tumor outgrowth and therapeutic invention strategies against lymphoma. Genetically altered mice including both transgenic and knockout mice offer important models to test the role of specific viral and host genes in the development of HTLV-1-associated lymphoma. Novel approaches in genetic manipulation of both HTLV-1 and animal models are available to address the complex questions that remain about viral-mediated mechanisms of cell transformation and disease. Current progress in the understanding of the molecular events of HTLV-1 infection and transformation suggests that answers to these questions are approachable using animal models of HTLV-1-associated lymphoma Oncogene (2005) 24, 6005-6015.

show abstract

Section: Rabbit Modelsmentioning

confidence: 99%

Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

2005

View full text Add to dashboard Cite

show abstract

“…PCR was performed on genomic DNA extracted from rabbit peripheral blood mononuclear cells using oligonucleotide primers at positions 7341-7360 and 7460-7441 corresponding to the pX region of HTLV-I, as described previously (Sawada et al, 1991). The amplified products were electrophoresed on 6% polyacrylamide gels, transferred to nylon membranes, and hybridized with a 32P-labelled internal probe (bases 7364-7383).…”

Section: Polymerase Chain Reaction (Pcr)mentioning

confidence: 99%

Vaccination of rabbits with recombinant vaccinia virus carrying the envelope gene of human T‐cell lymphotropic virus type I

Hakoda

Machida

Tanaka

et al. 1995

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

Two groups of 3 rabbits each were immunized with either recombinant vaccinia virus, WR-SFB5env, carrying the human T-cell lymphotropic virus type I (HTLV-I) env gene at the site of the hemagglutinin gene of the WR strain, or control vaccinia virus, HA-WR, lacking the functional hemagglutinin gene. All 6 rabbits responded with anti-vaccinia virus antibodies. WR-SFB5env elicited anti-HTLV-I env antibodies but no vesicular stomatitis virus (HTLV-I) pseudotype neutralizing antibodies in all 3 rabbits. After 10 weeks, the animals were challenged by transfusion of blood from an HTLV-I-infected rabbit. Two of the 3 vaccinated rabbits and all 3 control rabbits became infected with HTLV-I, as indicated by seroconversion and detection of HTLV-I proviral sequences by polymerase chain reaction. The rabbit that had been protected from initial challenge became infected with HTLV-I upon rechallenge 12 weeks after the first challenge. In view of the proven prophylactic effect of passive immunization against HTLV-I, our vaccine trial failed because WR-SFB5env was incapable of inducing neutralizing antibodies against HTLV-I in the immunized animals. It remains to be studied whether cell-mediated immunity such as antibody-dependent cellular cytotoxicity was involved in the temporary protection of I vaccinated rabbit.

show abstract

“…Our results further suggest that the COOH-terminal region of the external glycoprotein correlates with transmission. Taken together, these data imply that high-titered anti-HTLV-I antibodies, particularly those directed against the envelope protein, are associated with mother-to-child transmission, if the mother breast-feeds her child for 2 (29).…”

Section: Discussionmentioning

confidence: 79%

Association between maternal antibodies to the external envelope glycoprotein and vertical transmission of human T-lymphotropic virus type I. Maternal anti-env antibodies correlate with protection in non-breast-fed children.

Hino

Katamine²,

Miyamoto³

et al. 1995

J. Clin. Invest.

View full text Add to dashboard Cite

IntroductionVertical transmission of human T-lymphotropic virus type I (HTLV-I) depends primarily on breast-feeding; substitution of bottle-feeding has reduced the transmission rate from 20% in breast-fed children to 3% among bottle-fed. To determine the correlates of transmission for long breast-feeding (2 6 mo), short breast-feeding (< 6 mo), and bottlefeeding mothers, the antibody titers of transmitter (T) mothers and non-transmitter (nT) mothers were analyzed by using synthetic and recombinant epitopes representing the immunodominant epitopes of gag (Gagla, r24), env (Envl/5, MTA1, RE3), and tax (Tax8/22-24) proteins.Seroreactivity to gag and tax epitopes was not significantly different except for anti-r24 antibody titer, which was significantly higher among T-mothers (geometric mean 134) when compared with nT-mothers (62) in the long-feeding group (P < 0.001). Profiles of antibody titers against env epitopes were different. Within the long-feeding group, Envl/5, MTA1, and RE3 titers were significantly higher among T-mothers (258, 1,476, and 738, respectively) when compared with nT-mothers (106,279, and 320, respectively) (P < 0.01 for all three epitopes). In contrast, within the bottle-feeding group, antibody titers to Envl/5 (269) and RE3 (418) among nT-mothers were significantly higher than those among T-mothers (80 and 113, respectively) (P < 0.01). These data confirm that high-titered anti-HTLV-I antibodies in the long-feeding group correlate with milkborne transmission of HTLV-I and, more importantly, imply that maternal anti-env antibodies may reduce the risk of non-milkborne infection. (J. Clin. Invest. 1995Invest. . 95:2920Invest. -2925

show abstract

Immunoglobulin Prophylaxis against Milkborne Transmission of Human T Cell Leukemia Virus Type I in Rabbits

Cited by 55 publications

References 10 publications

Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

Vaccination of rabbits with recombinant vaccinia virus carrying the envelope gene of human T‐cell lymphotropic virus type I

Association between maternal antibodies to the external envelope glycoprotein and vertical transmission of human T-lymphotropic virus type I. Maternal anti-env antibodies correlate with protection in non-breast-fed children.

Contact Info

Product

Resources

About