Immunoglobulins in hydrops fetalis

Chiang, Wen-Tsuo; Wei, Po‐Li

doi:10.1016/0002-9378(72)90907-6

Cited by 7 publications

(1 citation statement)

References 5 publications

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“…Several reports have documented high perinatal mortality with fetal hydrops due to syphilis. [14][15][16][17] The hydropic fetus has a poor prognosis in spite of having a treatable infection, hence the decision for aggressive parenteral therapy of the mother.…”

Section: Infectious Diseases In Obstetrics and Gynecologymentioning

confidence: 99%

Intravenous Penicillin for Antenatal Syphilotherapy

Galan

Yandell

Knight

1992

Infectious Diseases in Obstetrics and Gynecology

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A 21 year old woman (G2 P0101) of 24 weeks gestation presented with syphilis of unknown duration. Sonography revealed fetal hydrops and placental thickening. Weekly intramuscular injections of 2.4 million U Bicillin for 3 weeks was initiated as recommended by the Centers for Disease Control. Repeat sonogram 1 week after starting treatment revealed increased ascites and a new pericardial effusion. Due to the worsening fetal condition, therapy was altered and the patient was admitted for IV penicillin. She received a continuous infusion of 18 million U penicillin G daily for 10 days. Serial sonograms showed improvement offetal ascites and pericardial effusion with 10 days of IV therapy, and complete resolution of hydrops was noted within 3 weeks. The fetus was born at term with no stigmata of congenital syphilis on newborn exam, and laboratory tests suggested adequate treatment in utero.

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Section: Infectious Diseases In Obstetrics and Gynecologymentioning

confidence: 99%