Immunohematology

Cooling, Laura; Downs, Theresa

doi:10.1016/b978-1-4377-0974-2.00035-x

Cited by 12 publications

(9 citation statements)

References 226 publications

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“…This may cause high incidence of chronic gastritis and gastric adenocarcinoma in the O and Le (a−b+) phenotypes 21. However, in our research, we did not determine any association between ABO and Lewis phenotypes with this infection.…”

Section: Discussioncontrasting

confidence: 67%

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Association of Helicobacter pylori infection with the Lewis and ABO blood groups in dyspeptic patients

et al. 2013

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Background:Helicobacter pylori infection is a basic risk factor for chronic gastritis, and gastric carcinoma. Based on some studies, the reason is binding of H. pylori to H and Leb antigens in gastric mucosa. However, some other findings have not determined any association between the infection and these antigens. Because of this controversy and the fact that H. pylori infection and gastric adenocarcinoma are common diseases in Iran, the assessment of the association of H. pylori infection with these blood groups could be valuable.Materials and Methods:In a cross sectional study on 135 adult dyspeptic patients in Mashhad, Iran, from 2009 to 2010, H. pylori infection was evaluated by using the Heliprobe 14C-urea breath test and the ABO and Lewis blood group antigens were determined by the tube method. Association between the Lewis and ABO phenotypes with H. pylori infection were analysed by Fisher's exact test. A P ≤ 0.05 was considered to be significant.Results:68 (50.4%) patients were positive for H. pylori infection. The frequencies of the ABO, Lewis and secretion phenotypes were not significant in the infected and non-infected patients. We also did not find a significant association between Lea and Leb antigens and this infection.Conclusion:We could not establish a significant association between the Lewis, ABO and secretion phenotypes with H. pylori infection. Diversity of sequences of blood group antigen b-binding adhesion (babA gene) of H. pylori may be a reason why our findings are different from other studies in other geographic areas.

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Section: Discussioncontrasting

confidence: 67%

“…As a result, subjects lacking the Se gene, non-secretors, can't form type 1H chain and antigens derived from it (Le b ) 111217. Hence, non-secretors can only form the Le a antigen 2021…”

Section: Discussionmentioning

confidence: 99%

Association of Helicobacter pylori infection with the Lewis and ABO blood groups in dyspeptic patients

et al. 2013

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“…The antibody response against nonprotein antigens, such as polysaccharides and lipids, primarily relies on IgM production . IgM is more capable of complement fixation and activation than IgG . The secondary antibody response of IgG subclasses to polysaccharide antigens also differs from the response to protein antigens.…”

Section: Discussionmentioning

confidence: 99%

“…IgG2 only weakly activates complement, while IgG4 does not . When considering these characteristics of IgM and IgG, it is intriguing that antigens of the ABO blood group system (as well as Lewis, I, and P) consist of carbohydrate epitopes resulting from the posttranslation modification of glycoproteins and glycolipids …”

Section: Discussionmentioning

confidence: 99%

ABO‐incompatible kidney transplantation can be successfully conducted by monitoring IgM isoagglutinin titers during desensitization

et al. 2020

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BACKGROUND Recent advances in desensitization techniques and immunosuppressive therapy have led to improved outcomes after ABO‐incompatible (ABO‐i) kidney transplantation (KT). However, questions remain unanswered, particularly regarding which type of ABO isoagglutinin—immunoglobulin M (IgM) or immunoglobulin M (IgG)—is significantly involved in antibody‐mediated rejection (AMR). STUDY DESIGN AND METHODS We retrospectively analyzed data from 120 patients who underwent ABO‐i KT between 2012 and 2014. Preoperative plasma exchange was performed until the IgM isoagglutinin titer was 4 or less, regardless of the IgG titer. Clinical data were compared between patient groups with pre‐KT IgG isoagglutinin titer 16 or greater (high IgG; titer range, 16‐256; n = 39) and 8 or less (low IgG; titer range, −8; n = 81). RESULTS The median follow‐up periods were 59 (high IgG) and 55 (low IgG) months. Patient survival at 5 years (p = 0.314) was 100% (high IgG) and 97.4% (low IgG). Graft survival at 5 years (p = 0.480) was 100% (high IgG) and 98.7% (low IgG). AMR by anti‐ABO antibody occurred in only one patient in the low‐IgG group. CONCLUSION Patients with high pre‐KT IgG isoagglutinin titers had equally successful outcomes as those with low IgG titers. ABO‐i KT can be successfully performed by reducing the pre‐KT IgM isoagglutinin titer to 4 or less, as determined by the immediate spin tube method.

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“…In ABO-incompatible marrow transplants, ABO antibodies can cause hemolysis, delaying the engrafting of red blood cells (RBC) and megakaryocytes [1]. …”

Section: Introductionmentioning

confidence: 99%

Comparison of Total and IgG ABO Antibody Titers in Healthy Individuals by Using Tube and Column Agglutination Techniques

Park

Shin

et al. 2014

Ann Lab Med

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BackgroundMost immune reactions related to transfusion and transplantation are caused by IgM ABO antibodies. However, IgG also plays an important role in these reactions. Therefore, a method to measure antibodies, including IgG, is necessary. We investigated ABO antibody titers of healthy individuals using a column agglutination technique (CAT) with or without dithiothreitol (DTT) and compared them with titers obtained using a conventional tube method.MethodsAmong healthy adults who underwent a medical examination, 180 individuals (60 with blood group A, 60 with group B, and 60 with group O) were selected. Antibody titrations were performed using the immediate spin (IS) tube, anti-human globulin (AHG) tube, and CAT with or without DTT methods.ResultsHigher median values of anti-B and anti-A titers in groups A and B individuals, respectively, were obtained using the IS method than using the AHG method. Higher values for group O individuals were obtained using the AHG method. Higher median titers of anti-B and anti-A in group O individuals were obtained using CAT without DTT than using the AHG method. Median titers of anti-B and anti-A in all blood groups were higher in CAT without DTT than in CAT with DTT, especially for group O individuals.ConclusionsWe recommend CAT with and without DTT for titration of anti-A and anti-B, especially in group O individuals, to provide more sensitive results that include IgG data. Adjustment of insurance coverage of fees associated with antibody titration might be necessary, considering the actual cost of reagents and personnel.

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Immunohematology

Cited by 12 publications

References 226 publications

Association of Helicobacter pylori infection with the Lewis and ABO blood groups in dyspeptic patients

Association of Helicobacter pylori infection with the Lewis and ABO blood groups in dyspeptic patients

ABO‐incompatible kidney transplantation can be successfully conducted by monitoring IgM isoagglutinin titers during desensitization

Comparison of Total and IgG ABO Antibody Titers in Healthy Individuals by Using Tube and Column Agglutination Techniques

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