Immunohistochemical analysis of mast cell infiltrates and microvessel density in oral squamous cell carcinoma

Pyziak, Łukasz; Stasikowska-Kanicka, Olga; Danilewicz, Marian; Wągrowska-Danilewicz, Małgorzata

doi:10.5114/pjp.2013.39336

Cited by 12 publications

(13 citation statements)

References 27 publications

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“…Theroleofprostatestromalcellsislittlestudied, bothinnormalstromaandinmalignantandbenign pathologyoftheprostate.Activationofthestromal microenvironmentisbelievedtobeanimportantelementinthegrowthandprogressionofadenocarcinoma.Thefirststepinunderstandingthestromal-tumorinteractionistodefinetheroleofeachstromal cellatonemomentofthedevelopmentofbenignand malignantprostatelesions.Reactivestromaisamixtureoffibroblasts,endothelialcells,myofibroblasts, MCsandotherimmunecells.Themastcellisoneof themostcontroversialstromalcells,theirrolebeing proved to be complex and thus incompletely elucidatedatthismoment.Severalstudieshavesuggested thepotentialinvolvementofMCsinthepathogenesis ofvarioustumorsasmelanocyticskinlesions [18]or squamouscellcarcinomas [19]butothersshowedthe relationship between MCs and tumors due to their cytotoxicactionontumorcells [20,21]ortheirabilitytodeliverproductswithananti-tumoreffect [22].…”

Section: Discussionmentioning

confidence: 99%

Mast cell phenotype in benign and malignant tumors of the prostate

Tatiana¹,

Şaptefrţi²,

Ceauşu³

et al. 2014

pjp

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Section: Discussionmentioning

confidence: 99%

Mast cell phenotype in benign and malignant tumors of the prostate

Tatiana¹,

Şaptefrţi²,

Ceauşu³

et al. 2014

pjp

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“…Similar to gingival overgrowth and oral cancer (Flynn et al 1991;Soory and Suchak 2001;Iamaroon et al 2003;Nurmenniemi et al 2004;Mohtasham et al 2010;Pyziak et al 2013), increased levels of degranulated mast cells and macrophages are associated with neurofibromas. Analysis of initial data suggests that the macrophages in NF1 tissues are not principally synthetic macrophages (Prada et al 2013), but additional studies are required.…”

Section: Gingival Overgrowth and Cancermentioning

confidence: 99%

Molecular and Clinical Aspects of Drug-induced Gingival Overgrowth

Trackman

Kantarcı²

2015

J Dent Res

133

109

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Drug-induced gingival overgrowth is a tissue-specific condition and is estimated to affect approximately one million North Americans. Lesions occur principally as side-effects from phenytoin, nifedipine, or ciclosporin therapy in approximately half of the people who take these agents. Due to new indications for these drugs, their use continues to grow. Here, we review the molecular and cellular characteristics of human gingival overgrowth lesions and highlight how they differ considerably as a function of the causative drug. Analyses of molecular signaling pathways in cultured human gingival fibroblasts have provided evidence for their unique aspects compared with fibroblasts from the lung and kidney. These findings provide insights into both the basis for tissue specificity and into possible therapeutic opportunities which are reviewed here. Although ciclosporin-induced gingival overgrowth lesions exhibit principally the presence of inflammation and little fibrosis, nifedipine-and especially phenytoin-induced lesions are highly fibrotic. The increased expression of markers of gingival fibrosis, particularly CCN2 [also known as connective tissue growth factor (CTGF)], markers of epithelial to mesenchymal transition, and more recently periostin and members of the lysyl oxidase family of enzymes have been documented in phenytoin or nifedipine lesions. Some oral fibrotic conditions such as leukoplakia and oral submucous fibrosis, after subsequent additional genetic damage, can develop into oral cancer. Since many pathways are shared, the study of gingival fibrosis and comparisons with characteristics and molecular drivers of oral cancer would likely enhance understandings and functional roles of molecular drivers of these oral pathologies.

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“…MC tryptase, that directly stimulate proliferation and migration of endothelial cells or indirectly degrade the connective tissue scaffold [19]. In two studies on oral squamous cell carcinoma, Lamaroon et al and Pyziak et al reported a significant relation between the number of MCs and angiogenesis, in agreement with the mentioned theory [12,20]. This positive correlation has also been observed in various tumors, e.g.…”

Section: Discussionmentioning

confidence: 59%