Immunohistochemical and ultrastructural evidence of a modified microvasculature in the giant cell granuloma of the jaws

Lim, Lydia; Gibbins, John R.

doi:10.1016/s1079-2104(05)80281-1

Cited by 32 publications

(31 citation statements)

References 28 publications

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“…Measurements were taken at the periphery of the CGCG lesions, in the surrounding areas beneath the oral epithelium lining, in cases where the jawbone was perforated. As these areas were characterized by reactive inflammatory tissue, including numerous newly formed vascular structures, they served as controls (4). Control areas in five cases of CGCG were analyzed for the mean percentage MVV of VEGF‐ and bFGF‐positive blood vessels in a manner identical to that previously described for the core of CGCG tissue.…”

Section: Methodsmentioning

confidence: 99%

Giant cell granuloma of the jawbones – a proliferative vascular lesion? Immunohistochemical study with vascular endothelial growth factor and basic fibroblast growth factor

Vered

Buchner

Dayan

2006

J Oral Pathology Medicine

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Section: Methodsmentioning

confidence: 99%

Giant cell granuloma of the jawbones – a proliferative vascular lesion? Immunohistochemical study with vascular endothelial growth factor and basic fibroblast growth factor

Vered

Buchner

Dayan

2006

J Oral Pathology Medicine

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“…None of the histologic or immunohistologic features yet described have allowed separation of aggressive from nonaggressive lesions. CGCG appears to be a tumor in which osteoclasts or their precursors are recruited into a predominantly fibroblastic field (52)(53). The fibroblasts are in cell cycle and may be responsible for production of cytokines or growth factors that support tumor growth.…”

Section: Central Giant Cell Granuloma and Other Giant Cell Lesions Ofmentioning

confidence: 99%

Odontogenic Cysts, Odontogenic Tumors, Fibroosseous, and Giant Cell Lesions of the Jaws

2002

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Odontogenic cysts that can be problematic because of recurrence and/or aggressive growth include odontogenic keratocyst (OKC), calcifying odontogenic cyst, and the recently described glandular odontogenic cyst. The OKC has significant growth capacity and recurrence potential and is occasionally indicative of the nevoid basal cell carcinoma syndrome. There is also an orthokeratinized variant, the orthokeratinized odontogenic cyst, which is less aggressive and is not syndrome associated. Ghost cell keratinization, which typifies the calcifying odontogenic cyst, can be seen in solid lesions that have now been designated odontogenic ghost cell tumor. The glandular odontogenic cyst contains mucous cells and ductlike structures that may mimic central mucoepidermoid carcinoma. Several odontogenic tumors may provide diagnostic challenges, particularly the cystic ameloblastoma. Identification of this frequently underdiagnosed cystic tumor often comes after one or more recurrences and a destructive course. Other difficult lesions include malignant ameloblastomas, calcifying epithelial odontogenic tumor, squamous odontogenic tumor, and clear-cell odontogenic tumor. Histologic identification of myxofibrous lesions of the jaws (odontogenic myxoma, odontogenic fibroma, desmoplastic fibroma) is necessary to avoid the diagnostic pitfall of overdiagnosis of similar-appearing follicular sacs and dental pulps. Fibroosseous lesions of the jaws show considerable microscopic overlap and include fibrous dysplasia, ossifying fibroma, periapical cementoosseous dysplasia, and low-grade chronic osteomyelitis. The term fibrous dysplasia is probably overused in general practice and should be reserved for the rare lesion that presents as a large, expansile, diffuse opacity of children and young adults. The need to use clinicopathologic correlation in assessing these lesions is of particular importance. Central giant cell granuloma is a relatively common jaw lesion of young adults that has an unpredictable behavior. Microscopic diagnosis is relatively straightforward; however, this lesion continues to be somewhat controversial because of its disputed classification (reactive versus neoplastic) and because of its management (surgical versus. medical). Its relationship to giant cell tumor of long bone remains undetermined.

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“…[11] Lim and Gibbins also have suggested that the MGCs in CGCG are similar to osteoclasts and express TRAP 5 and MB1. [18] Likewise, Src expression in cherubism, giant cell tumor, and CGCG has been shown by Wang et al . [13]…”

Section: Discussionmentioning

confidence: 88%

Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws

Khiavi

Aghbali

Halimi

et al. 2013

J Oral Maxillofac Pathol

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Aim and Objective:The aim of this study was to investigate the expression of Src protein (an osteoclastic factor) in peripheral and central giant cell granulomas (PGCG and CGCGs) of the jaws and the relationship between the expression of this protein and the clinical behavior of these two lesions.Materials and Methods:Thirty cases of PGCG and 30 cases of CGCG were immunohistochemically stained with Src. A staining-intensity-distribution (SID) score (proportion of stained cells × staining intensity) was used to evaluate immunoreactivity of the protein. Data were analyzed using statistical package for social sciences (SPSS) 17.0.Results:There were no significant differences in the Src expression and the SID score between PGCG and CGCG. Furthermore, Spearman's rank correlation coefficient showed that there was a significant correlation between Src expression and SID score within both PGCG and CGCG (P < 0.001; r = 0.87 and 0.75, respectively).Conclusion:The findings of this study suggest that the multinucleated giant cells share some similarities with osteoclasts and Src protein can be used as a new therapeutic target to inhibit osteoclastic activity. In addition, differences in immunoreactivity of this osteoclastic protein do not reflect different clinical behaviors of PGCG and CGCG.

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Immunohistochemical and ultrastructural evidence of a modified microvasculature in the giant cell granuloma of the jaws

Cited by 32 publications

References 28 publications

Giant cell granuloma of the jawbones – a proliferative vascular lesion? Immunohistochemical study with vascular endothelial growth factor and basic fibroblast growth factor

Giant cell granuloma of the jawbones – a proliferative vascular lesion? Immunohistochemical study with vascular endothelial growth factor and basic fibroblast growth factor

Odontogenic Cysts, Odontogenic Tumors, Fibroosseous, and Giant Cell Lesions of the Jaws

Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws

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