Immunohistochemical investigation of SV40 large T antigen in Hodgkin and non‐Hodgkin's lymphoma

Brousset, Pierre; Araujo, Valquiria de; Gascoyne, Randy D.

doi:10.1002/ijc.20397

Cited by 25 publications

(18 citation statements)

References 15 publications

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“…A recent meta-analysis of data from 589 primary brain cancer samples and 414 control samples conclusively established that SV40 is significantly associated with those malignancies. 17 Although very complete, that paper lacked important data, recently published 6 18 or in press, 19 showing negative results in particular in lymphomas. In a recent study, 19 using the same immunohistochemical approach, we were unable to detect positivity in 482 cases of lymphoma from France and Canada.…”

Section: Resultsmentioning

confidence: 99%

“…17 Although very complete, that paper lacked important data, recently published 6 18 or in press, 19 showing negative results in particular in lymphomas. In a recent study, 19 using the same immunohistochemical approach, we were unable to detect positivity in 482 cases of lymphoma from France and Canada. Our results are clearly at variance with those recently presented at the meeting of the American Association for Cancer Research by Samaniego and colleagues 20 and Vilchez et al 21 22 Samaniego et al, 20 found an unusual pattern of staining with the anti-Tag (Pab419) antibody.…”

Section: Resultsmentioning

confidence: 99%

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Immunodetection of SV40 large T antigen in human central nervous system tumours: Figure 1

Sabatier

Uro‐Coste²,

A³

et al. 2005

J Clin Pathol

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Background/Aims:DNA sequences from Simian virus 40 (SV40) have been previously isolated from various human tumours of the central nervous system (CNS). This study aimed to investigate a series of tumours of the CNS for the expression of the SV40 large T antigen (Tag), which is an oncogenic protein of the virus.Methods:A French series of 82 CNS tumours was investigated for Tag expression using a monoclonal antibody and immunohistochemistry. A Tag positive hepatocellular carcinoma cell line from transgenic mice and a kidney biopsy from a patient infected by SV40 were used as positive controls.Results:None of the tumours (20 ependymomas, 20 glioblastomas, 12 oligodendrogliomas, three plexus choroid adenomas, two plexus choroid carcinomas, 15 meningiomas, and 10 medulloblastomas) contained SV40 Tag positive cells.Conclusions:The lack of SV40 Tag in 82 CNS tumours of various types is at variance with previous studies from different countries, and suggests that the virus may not be an important factor in CNS tumorigenesis, at least in French cases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Immunodetection of SV40 large T antigen in human central nervous system tumours: Figure 1

Sabatier

Uro‐Coste²,

A³

et al. 2005

J Clin Pathol

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“…Tissue probes of both ureters were stained for SV40 large T antigen (clone pAb416, Oncogene Science, Boston, Mass, USA; dilution 1 : 100, antigen retrieval and amplification with catalyzed system amplification, Dako, Carpinteria, CA). The reactions were detected by means of the streptavidin-biotin method and were revealed using diaminobenzidine as a chromogen [15, 16]. In all tissue probes immunohistochemistry for large T antigen was negative (Figure 3(b)).…”

Section: Case Reportmentioning

confidence: 99%

Hydronephrosis Resulting from Bilateral Ureteral Stenosis: A Late Complication of Polyoma BK Virus Cystitis?

Basara

Rasche

Schwalenberg

et al. 2010

Journal of Transplantation

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We report here a case of acute lymphoblastic leukemia in remission presenting a late-onset bilateral hydronephrosis probably due to polyoma BK virus-induced proliferation of bladder endothelium on both ostii. The diagnosis was made virologically by BK virus Polymerase Chain Reaction (PCR) detection in the absence of any other bladder disease. Awareness of this late complication is necessary not only in patients after renal transplantation but also in patients after hematopoietic stem cell transplantation from matched unrelated donor.

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“…The authors concluded that the inconsistent, low-level detection of SV40 DNA in mesothelioma specimens in their laboratory, and perhaps other laboratories, was likely to be the result of contamination of PCR reagents or tissue specimens by cloning vectors [15]. Likewise, recent studies that have used immunohistochemistry have failed to identify the presence of T-antigen in tumor cells [15,52]. Therefore, it remains uncertain whether SV40 DNA is actually present in human tumors.…”

Section: Expert Opinionmentioning

confidence: 99%

Cancer risk associated with receipt of vaccines contaminated with simian virus 40: epidemiologic research

Engels¹

2005

Expert Review of Vaccines

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Simian virus (SV)40 was an accidental contaminant of poliovirus vaccines used widely in the USA and other countries in 1955-1962. Exposure to SV40 via contaminated vaccines has led to concern as SV40 causes cancer in laboratory animals. In addition, some laboratories, although not all, have detected SV40 DNA in human tumors including mesothelioma, certain brain tumors, osteosarcoma and non-Hodgkin's lymphoma. This article reviews the data regarding contamination of poliovirus vaccines with SV40 and summarizes the results from epidemiologic studies of vaccine recipients. Long-term follow-up studies have not revealed recipients of SV40-contaminated poliovirus vaccines to be at an increased risk for cancer. Thus, these studies are somewhat reassuring and indicate that either SV40 does not readily infect humans or, following infection, does not cause cancer. Recognizing that the history of SV40 contamination of vaccines highlights an inherent risk of contamination of vaccines with adventitious agents, the Institute of Medicine recently called for the development of a comprehensive US plan to prevent vaccine contamination and respond to potential contamination events when they arise.

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Immunohistochemical investigation of SV40 large T antigen in Hodgkin and non‐Hodgkin's lymphoma

Cited by 25 publications

References 15 publications

Immunodetection of SV40 large T antigen in human central nervous system tumours: Figure 1

Immunodetection of SV40 large T antigen in human central nervous system tumours: Figure 1

Hydronephrosis Resulting from Bilateral Ureteral Stenosis: A Late Complication of Polyoma BK Virus Cystitis?

Cancer risk associated with receipt of vaccines contaminated with simian virus 40: epidemiologic research

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