Immunohistochemical Studies of Mammary Tumors Induced by the Direct Application of Dmba Powder to Rat Mammary Glands

Tsubura, Airo; Morii, Sotokichi

doi:10.1293/tox.1.157

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…These sections were stained with hematoxylin-eosin, pyronin-methylgreen, and several immunohistochemical methods. For visualization of type IV collagen, actin, desmin, and vimentin, methods previously described (13) were used. The remaining deparaffinized sections were used in the measurement of BrdU-incorporated nuclei (1,8) .…”

Section: Methodsmentioning

confidence: 99%

Rapid recovery of leydig cell population in rar cryptorchid testes after ethanedime-thanesulfonate injury: Immuno-histochemical studies.

Naka

Inui

Okada

et al. 1991

Acta Histochem. Cytochem

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Precursor cells in the rapid recovery of Leydig cells after depletion by ethanedimethanesulfonate (EDS) injury to bilateral abdominal testes were examined immunohistochemically 8, 11, and 14 days after an intraperitoneal injection of EDS, 75 mg/kg, 2 weeks after cryptorchidization.Compared with shamoperated rats, the repopulation of Leydig cells in cryptorchid rats was accelerated. Row-like arranged fusiform-shaped mesenchymal cells were found in peritubular regions of abdominal testes 14 days after EDS injection. At 11 days after injection, a significant increase of bromodeoxyuridine-incorporated nuclei was noted in peritubular mesenchymal cells of abdominal testes when compared with scrotal testes. In intertubular tissues, both attenuated mesenchymal cells in earlier stages and fusiform-shaped mesenchymal cells in later stages were actin-, desmin-, and vimentin-negative, and the cells later revealed marked pyronophilia.Therefore, division of peritubular mesenchymal cells seems to contribute somewhat to the rapid recovery of abdominal testes, although differentiation through cytoplasmic pyronophilia from a pool of mesenchymal stem cells give rise to the main part of new Leydig cell populations.

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Section: Methodsmentioning

confidence: 99%

Rapid recovery of leydig cell population in rar cryptorchid testes after ethanedime-thanesulfonate injury: Immuno-histochemical studies.

Naka

Inui

Okada

et al. 1991

Acta Histochem. Cytochem

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“…Myoepithelial cells are unique cells that contain contractile proteins and have identified with the immunohistochemical methods for actin or myosin (11,16,17). These proteins, however, are not restricted to the myoepithelial cells and are detected sometimes in the epithelial-derived tumor cells.…”

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confidence: 99%

Immunohistochemical reactivity of a monoclonal antibody against cell membranes of human mammary carcinoma cells (125B4) with rat normal tissues and DMBA-induced mammary tumors.

Tsubura

Inui

Senzaki

et al. 1989

Acta Histochem. Cytochem

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Immunolocalization of the human basal epithelial marker monoclonal antibody 312C8-1 in normal tissue and mammary tumours of rodents

Tsubura

Inui

Senzaki

et al. 1989

Vichows Archiv A Pathol Anat

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Immunohistochemical Studies of Mammary Tumors Induced by the Direct Application of Dmba Powder to Rat Mammary Glands

Abstract: Abstract:Immunohistochemical studies were

Cited by 7 publications

References 21 publications

Rapid recovery of leydig cell population in rar cryptorchid testes after ethanedime-thanesulfonate injury: Immuno-histochemical studies.

Rapid recovery of leydig cell population in rar cryptorchid testes after ethanedime-thanesulfonate injury: Immuno-histochemical studies.

Immunohistochemical reactivity of a monoclonal antibody against cell membranes of human mammary carcinoma cells (125B4) with rat normal tissues and DMBA-induced mammary tumors.

Immunolocalization of the human basal epithelial marker monoclonal antibody 312C8-1 in normal tissue and mammary tumours of rodents

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