Immunohistochemical Study of Age-dependent Brain Lesions in Mice Infected Intracerebrally with Kasba (Chuzan) Virus

Immunoperoxidase labeling was performed in histological sections from rat brain harvested during acute (10-30 days), clinically inapparent (90-270 days) and late (450-540 days) stages of Junin virus-induced neurological disease. In frontoparietal cortex, count of viral antigen (+) neurons peaked during the acute period (27.7+/-6.8), dropped within the intermediate (4.8+/-4.0 to 1.4+/-1.1) and increased (7.6+/-4.3) at the onset of the late neurological syndrome. In infected vs. control rats, the number of GFAP (+) astrocytes maximized during the acute stage (19+/-4 vs. 11+/-5), and from the end of the intermediate (27+/-5 vs. 21+/-5) up to the late (37+/-7 vs. 26+/-6) periods. In turn, surface density of GFAP (+) material in infected samples peaked at 0.196+/-0.066, while it failed to exceed 0.090+/-0.043 in controls. Both astrocyte hypertrophy relapsing into chronicity, as depicted by surface density, and astrocyte hyperplasia preceding the onset of the late neurological syndrome, support their pathogenic contribution to disease expression.

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Long-lasting astrocyte reaction to persistent Junin virus infection of rat cortical neurons

Caccuri

Iacono

Weissenbacher

et al. 2003

Journal of Neural Transmission

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A single-tube RT-PCR for rapid detection and differentiation of some African isolates of palyam serogroup orbiviruses

Aradaib

Mohamed

Abdalla

2009

Journal of Virological Methods

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Immunohistochemical Study of Age-dependent Brain Lesions in Mice Infected Intracerebrally with Kasba (Chuzan) Virus

Cited by 2 publications

References 8 publications

Long-lasting astrocyte reaction to persistent Junin virus infection of rat cortical neurons

Long-lasting astrocyte reaction to persistent Junin virus infection of rat cortical neurons

A single-tube RT-PCR for rapid detection and differentiation of some African isolates of palyam serogroup orbiviruses

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