Immunohistological Features in Adenomatoid Odontogenic Tumor: Review of the Literature and First Expression and Mutational Analysis of β-Catenin in This Unusual Lesion of the Jaws

Harnet, Jean-Claude; Pédeutour, Florence; Raybaud, Hélène; Fabas, Thibault; Lombardi, Tommaso

doi:10.1016/j.joms.2012.10.006

Cited by 15 publications

(17 citation statements)

References 41 publications

(41 reference statements)

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“…According to the literature, AOTs have shown CK5, CK14, CK17 and CK19 positivity, which is similar to the cytokeratin profile of dentigerous cyst and oral gingival epithelium. In addition, the non-aggressive nature of the AOT is supported by low expression of proliferative markers such as PCNA and Ki-67 [15]. In accordance with the literature, similar CK 19 expression patterns and low Ki-67 expression were observed in our cases as well.…”

Section: Discussionsupporting

confidence: 92%

Clinico-Pathological Presentations of Cystic and Classic Adenomatoid Odontogenic Tumors

et al. 2019

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The objective of the study is to present the clinico-pathological features of cystic and classic adenomatoid odontogenic tumors (AOTs) in order to identify the differences between the two variants of AOT. Materials and method: The study sample comprised of 41 AOTs, which were categorized into cystic and classic AOTs. Cystic AOTs are diagnosed as such when macroscopic and microscopic evidence of a cyst is present together with histopathological criteria of AOT (WHO–2017). Results: The study sample comprised of eleven cystic and thirty classic AOTs. Eight cystic AOTs were regarded as arising from dentigerous cysts as these lesions were attached to the cemento-enamel junction of the impacted teeth. Though not statistically significant, in contrast to classic AOTs which showed female predilection, cystic AOTs were more prevalent in males. Cystic AOTs tend to present as significantly larger lesions compared to classic AOTs (p < 0.02). In both cystic and classic AOTs, duct-like structures and epithelial whorls were the two most prominent histopathological features present in the majority of tumors. Two AOTs with massive amounts of dentinoid occurred in the mandible and presented as large lesions that eroded cortical bone. None of the 12 patients with follow-up information presented with recurrences. Conclusion: Except for the size of the lesion, no significant clinico-pathological differences were observed between cystic and classic AOTs. Therefore the cystic AOTs can be considered as a variant of AOT with enucleation, simple excision, or radical excision as the treatment of choice depending on the extent of the lesion, similar to classic AOTs.

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Section: Discussionsupporting

confidence: 92%

Clinico-Pathological Presentations of Cystic and Classic Adenomatoid Odontogenic Tumors

et al. 2019

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“…Beta‐catenin, a member of the Wnt signaling pathway, plays an important role in dental development and also plays in epithelial cell‐to‐cell adhesion. Harnet et al () demonstrated an absence of nuclear expression but a strong cytoplasmic and membranous staining of the columnar and cuboidal cells of duct‐like structures and solid nodules within the follicular type of AOT, claiming their results were in agreement with the benign clinical behavior and nature of the AOT when comparing similar studies of beta‐catenin expression in ameloblastomas.…”

Section: Resultsmentioning

confidence: 80%

Immunoprofile of the adenomatoid odontogenic tumor

Reichart

Philipsen²,

Khongkhunthian

et al. 2016

Oral Diseases

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This study was focused on the immunohistochemical profile of the adenomatoid odontogenic tumor. A Pub/Medline search revealed a number of immunohistochemical studies including cytokeratin profiles, extracellular matrix proteins, Integrins, ameloblast-associated proteins resorption regulators (RANK, RANKL), p53, PCNA, MDM2 protein, cyclin D1, Ki-67, Bcl-2 metallothionein, metalloproteinases, D56 hepatocyte growth factor, c-met, DNA methyltransferase, podoplanin, TGF-βI, Smad-2/3, Smad-I-5/-8, Smad 4, beta- catenin, calretinin, and clonality. Careful interpretation of the findings indicates that the adenomatoid odontogenic tumor may be more of a hamartomatous than neoplastic nature.

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“…The #MeSH words used were adenomatoid odontogenic tumor, odontogenic, and case report. We reviewed the data associated with AOT from 2000 to 2014,[3456781314151617181920212223242526272829303132333435363738394041424344454647484950515253545556575859606162636465666768697071727374757677787980818283848586878889919293] and it was found that in the last 14 years, there was a record of 255 reported cases.…”

Section: Discussionmentioning

confidence: 99%

A case report and short review on changing trends in the site of occurrence of adenomatoid odontogenic tumor: Unravelling the past 15 years

Sethi¹,

Kumar

Aggarwal³

et al. 2016

Dent Res J

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Adenomatoid odontogenic tumor (AOT) is an uncommon benign odontogenic lesion, with debatable histogenesis and variable histopathology. A systematic and diverse insight into the evolution, clinical presentation, histology, and immunohistochemical findings of this lesion is reviewed and presented. We reviewed the data published from 2000 to 2014 of approximately 255 cases that revealed a significant change in the incidence of predominant site involved, in contrast to the findings published by Reichart. We have also included the chronological order of events leading to the coining of the term AOT, which shows the curiosity that has been dedicated to understanding the lesion. Immunohistochemistry is considered to be a hallmark in pathology for learning the molecular pathogenesis and giving a correct final diagnosis. Several markers have been used to investigate and understand this lesion, and a compilation of the findings has been tabulated.

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Immunohistological Features in Adenomatoid Odontogenic Tumor: Review of the Literature and First Expression and Mutational Analysis of β-Catenin in This Unusual Lesion of the Jaws

Cited by 15 publications

References 41 publications

Clinico-Pathological Presentations of Cystic and Classic Adenomatoid Odontogenic Tumors

Clinico-Pathological Presentations of Cystic and Classic Adenomatoid Odontogenic Tumors

Immunoprofile of the adenomatoid odontogenic tumor

A case report and short review on changing trends in the site of occurrence of adenomatoid odontogenic tumor: Unravelling the past 15 years

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