Immunologic Susceptibility to Chronic Dermatophytosis

Jones, Henry E.

doi:10.1001/archderm.1974.01630080015005

Cited by 115 publications

(24 citation statements)

References 24 publications

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“…It is possible that this accounts for the absence of demonstrable circulating antibodies. Several workers have emphasized defective cellular immune responses in some of these patients (Hanifin, Ray and Lobitz, 1974;Jones, Reinhardt and Rinaldi, 1974).…”

Section: Resultsmentioning

confidence: 99%

Failure of treatment in chronic dermatophyte infections

Hay

1979

Postgraduate Medical Journal

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Section: Resultsmentioning

confidence: 99%

Failure of treatment in chronic dermatophyte infections

Hay

1979

Postgraduate Medical Journal

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“…Severity, duration and type of the disease had no impact on the prevalence of tinea pedis in both psoriasis and atopic dermatitis, although severity of the disease in atopic dermatitis, as revealed by the SCORAD score, approached significance ( P = 0.055). Most probably, this is due to the fact that chronic dermatophyte infection might exacerbate atopic dermatitis . Nissen et al .…”

Section: Discussionmentioning

confidence: 99%

“…While the exact prevalence of tinea pedis in atopic dermatitis is as yet unknown, there are interesting data regarding the susceptibility of atopic dermatitis patients to chronic dermatophytosis . Jones et al .…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of tinea pedis in psoriasis, compared to atopic dermatitis and normal controls – a prospective study

Leibovici

Ramot

Siam

et al. 2014

Mycoses

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There are discrepancies in the literature regarding the prevalence of tinea pedis in psoriasis. The aim of this investigation was to conduct a cross-sectional study of the prevalence of tinea pedis in psoriasis compared to atopic dermatitis patients and normal controls. We enrolled 232 psoriatic patients, 190 atopic dermatitis patients and 202 normal controls, between the years 2010 and 2013. The prevalence of tinea pedis was 13.8% in psoriasis patients, not significantly different from that in atopic dermatitis patients 8.4% (P = 0.092)), but significantly higher than in normal controls 7.4% (P = 0.043). Both gender and age affected the prevalence of tinea pedis in psoriasis and normal controls, while only age affected the prevalence of tinea pedis in atopic dermatitis. Regarding gender, there was higher prevalence of tinea pedis in men: 19.1% (P = 0.019) in psoriasis and 12.1% (P = 0.013) in normal controls. Age affected the prevalence of tinea pedis in normal controls (P < 0.001), psoriasis patients (P = 0.001) and atopic dermatitis patients (P = 0.001), with higher prevalence with increasing age. Trichophyton rubrum was the most common species in psoriasis (71.9%), atopic dermatitis (75.0%) and normal controls (73.3%). Our study found a relatively high prevalence of tinea pedis among psoriasis patients.

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“…When the fractions of 100,000 x g supernatant, separated by column chromatography, were tested in the mouse footpad system, none produced a strong 24-h reaction, but one produced a large 4-h response. This same fraction (16)(17)(18)(19)(20)(21)(22)(23)(24) also contained demonstrable activity in immunodiffusion against the rabbit antiserum to C. neoformnans B551; a similar pattern was seen with the post-mitochondrial supernatant. When this fraction was examined by the Piazzi immunodiffusion technique in conjunction with cryptococcal polysaccharide, using the same antiserum, it produced two or three lines of precipitation.…”

Section: Resultsmentioning

confidence: 70%

Delayed-type hypersensitivity responses in infected mice elicited by cytoplasmic fractions of Cryptococcus neoformans

Hay¹,

Reiss²

1978

Infect Immun

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Four subcellular fractions of Cryptococcus neoformans prepared by differential centrifugation of disrupted whole yeast and a 3-day culture filtrate were examined for their ability to elicit delayed-type hypersensitivity in sensitized animals. The methods used to detect sensitization were (i) the footpad swelling test and inhibition of peritoneal macrophage migration in mice and (ii) skin testing in guinea pigs. Two entities, the post-mitochondrial supernatant and the culture filtrate, showed considerable activity in the footpad test, with 26-and 30-,A 24-h swellings, respectively, at 6 weeks after infection. With the latter there was interference from a strong antibody-mediated 4-h skin reaction. The post-mitochondrial supernatant produced strong delayed-type hypersensitivity in guinea pigs at a dose of 69 ,ug, and there was no demonstrable cross-reactivity in animals sensitized with heterologous fungi. The footpad swelling in mice correlated well with the macrophage migration inhibition test, with 71% inhibition in mice infected subcutaneously with C. neoformans at 6 weeks. However, mice infected intravenously developed poorer cell-mediated immunity than the subcutaneously infected mice. The post-mitochondrial supernatant was found to contain detectable amounts of cryptococcal capsular polysaccharide.

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Immunologic Susceptibility to Chronic Dermatophytosis

Cited by 115 publications

References 24 publications

Failure of treatment in chronic dermatophyte infections

Failure of treatment in chronic dermatophyte infections

Prevalence of tinea pedis in psoriasis, compared to atopic dermatitis and normal controls – a prospective study

Delayed-type hypersensitivity responses in infected mice elicited by cytoplasmic fractions of Cryptococcus neoformans

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