Immunological, Cytogenetic and Hepatoprotective Effect of Viola odorata Methanolic Extract on Methotrexate Induced Albino Male Mice

Ibrahim, Ruqaya Mohammed

doi:10.24126/jobrc.2017.11.2.523

JoBRC

2017

DOI: 10.24126/jobrc.2017.11.2.523

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Immunological, Cytogenetic and Hepatoprotective Effect of Viola odorata Methanolic Extract on Methotrexate Induced Albino Male Mice

Ruqaya Mohammed Ibrahim¹

Abstract: Pants used in traditional medicine contain a vast array of substances that can be used to treat chronic and infectious diseases. One of these medical plant Viola odorata which a popularly known as “Banafshah” and sweet violet in Asia and Europe respectively. It is found in high altitudes of Himalyas, Europe and throughout North America. The study was designed to assess immunological (total and differential count of white blood cells), cytogenetic (micronucleus formation) and hepatoprotective activity of methan… Show more

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Cited by 2 publications

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Histological Effect of Viola Odorata Methanolic Extract and Methotraxate Induced in Albino Male Mice

Al-Jumaili¹,

Soud²,

Abdalla³

et al. 2019

JPP

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The objective of this study was to considere as an explorer for in vivo studies on the production of some secondary metabolites from local medical plants named Viola odorata. Viola odorata commonly known as "garden violet or sweet violet" belongs to family Violaceae, is a slow growing perennial, with stout rootstock, grows in hedgerows, rough land and margins of woodland. 200 mg/kg of methanol extract for V. odorata was interacted with methotrexate as a drug in albino mice to see the healing capacity for this extract. Different organs were used such as intestine, kidney, spleen, and testes for this experiment. Each organ response was recorded in this experiment. Histopathological section in the intestine of animal treated with MTX and plant showed hypertrophy and hyperplasia of goblet cells and increased cellularity of lamna properia while Histopathological section in the testes of animal treated with MTX and plant showed no sperm in the seminiferous tubules of epididymis with the round multi-nuclei cell in the lumen accompanied by homogeneous material and cellular debris while Histopathological section in the spleen of animal treated with MTX and plant proliferation of lymphocytes in the periarteriolar sheath and proliferation of mononuclear cells around sinus in red pulp and Histopathological section in the kidney of animal treated with MTX and plant mononuclear cells aggregation in the interstitial tissue mainly around blood vessels and in the adipose tissue and renal tubules. Other sections showed hydropic degeneration of renal tubules.

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Histological Effect of Viola Odorata Methanolic Extract and Methotraxate Induced in Albino Male Mice

Al-Jumaili¹,

Soud²,

Abdalla³

et al. 2019

JPP

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Protective activity of Ruta chalepensis methanolic extract against nephrotoxicity and testicular damage induced by Carbon tetrachloride on albino male mice

Yahya

Okhti

Al-Ezzy

et al. 2021

RJPT

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Herbal medicinal products can contain whole or partially prepared plant components from plant leaves, bark, stems, flowers and seeds.They are administered orally, inhaled or directly applied in the skin. Ruta chalepensis is a wild herb of the Mediterranean region used by many countries in herbal medicine. The existence of bioactive molecules responsible for their pharmacological properties has been shown by phytochemical screening. Results of kidney protective activity of plant. Showed that: for total cholesterol, the effect was dose dependant (50 and 100 mg\kg) in which the plant decreased it in compared to positive and negative groups (162.1±1.83 and 154.6±1.11 mg\dl) compared to (202.1±1.13 and 167.5±2.96 mg\dl) respectively. For total protein, creatinin and albumin the plant also had the ability to keep it near control groups compared to CCL4group.While the results of interaction groups indicated the ability of plant to provide protection against CCL4 damage. the plant possessed the ability to keep testosterone, progesterone and estrogen hormones level near normal in compared to CCL4 treated group (2.96±0.03, 1.93±0.01 and 3.63±0.04 ng\dl); (11.51±4.12, 9.85±2.18 and 11.78±3.42 ng\ml); (29.07±7.21, 30.11±9.11 and 30.67±8.98 ng\ml) for 50,100 mg\kg and negative control respectively. While for interaction group the results showed the ability of plant to counteract the damaged caused by CCL4 (1.67±0.01, 2.54±0.02); (10.42±2.21, 13.65±4.37); (39.74±10.13, 35.45±9.91) for testosterone, progesterone and estrogen hormones in Ruta chalepensis +CCL4 at dose (50 +0.02%) and (100+0.02%) respectively. All results of histo-architecture for kidney and testis showed the ability of plant to counteract any necrosis and abnormality caused by CCL4.

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Immunological, Cytogenetic and Hepatoprotective Effect of Viola odorata Methanolic Extract on Methotrexate Induced Albino Male Mice

Cited by 2 publications

References 19 publications

Histological Effect of Viola Odorata Methanolic Extract and Methotraxate Induced in Albino Male Mice

Histological Effect of Viola Odorata Methanolic Extract and Methotraxate Induced in Albino Male Mice

Protective activity of Ruta chalepensis methanolic extract against nephrotoxicity and testicular damage induced by Carbon tetrachloride on albino male mice

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