Immunological Interactions of Tuberculosis with Drugs and Substance Use: A Systematic Review and Update

Kiboi, Nathan G; Nebere, Saraphine Nekesa; Karanja, Joseph K.

doi:10.4172/2161-105x.1000326

Cited by 7 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, cocaine use attenuates the capacity of monocyte and alveolar macrophage protective mechanisms, resulting in failure to respond to a mycobacterial challenge, the ultimate consequence of which is a failure to prevent active tuberculosis. 60 …”

Section: Risk Factors For Tuberculosismentioning

confidence: 99%

Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of other drugs

et al. 2018

View full text Add to dashboard Cite

Tuberculosis continues to be a major public health problem. Although efforts to control the epidemic have reduced mortality and incidence, there are several predisposing factors that should be modified in order to reduce the burden of the disease. This review article will address some of the risk factors associated with tuberculosis infection and active tuberculosis, including diabetes, smoking, alcohol use, and the use of other drugs, all of which can also contribute to poor tuberculosis treatment results. Tuberculosis can also lead to complications in the course and management of other diseases, such as diabetes. It is therefore important to identify these comorbidities in tuberculosis patients in order to ensure adequate management of both conditions.

show abstract

Section: Risk Factors For Tuberculosismentioning

confidence: 99%

Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of other drugs

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Initiation of substance use and sexual activity also may contribute to the increase in TB disease progression and mortality in adolescents. Recreational drugs, alcohol, and smoking all are associated with increased risk of TB disease (179–182). Sexual activity may lead to pregnancy, which can predispose a woman to TB disease progression due to a wide range of immunosuppressive effects (183, 184).…”

Section: Beyond Age- and Sex-related Immunological Changes In Childrementioning

confidence: 99%

The Wonder Years: What Can Primary School Children Teach Us About Immunity to Mycobacterium tuberculosis?

et al. 2018

View full text Add to dashboard Cite

In high burden settings, the risk of infection with Mycobacterium tuberculosis increases throughout childhood due to cumulative exposure. However, the risk of progressing from tuberculosis (TB) infection to disease varies by age. Young children (<5 years) have high risk of disease progression following infection. The risk falls in primary school children (5 to <10 years), but rises again during puberty. TB disease phenotype also varies by age: generally, young children have intrathoracic lymph node disease or disseminated disease, while adolescents (10 to <20 years) have adult-type pulmonary disease. TB risk also exhibits a gender difference: compared to adolescent boys, adolescent girls have an earlier rise in disease progression risk and higher TB incidence until early adulthood. Understanding why primary school children, during what we term the “Wonder Years,” have low TB risk has implications for vaccine development, therapeutic interventions, and diagnostics. To understand why this group is at low risk, we need a better comprehension of why younger children and adolescents have higher risks, and why risk varies by gender. Immunological response to M. tuberculosis is central to these issues. Host response at key stages in the immunopathological interaction with M. tuberculosis influences risk and disease phenotype. Cell numbers and function change dramatically with age and sexual maturation. Young children have poorly functioning innate cells and a Th2 skew. During the “Wonder Years,” there is a lymphocyte predominance and a Th1 skew. During puberty, neutrophils become more central to host response, and CD4+ T cells increase in number. Sex hormones (dehydroepiandrosterone, adiponectin, leptin, oestradiol, progesterone, and testosterone) profoundly affect immunity. Compared to girls, boys have a stronger Th1 profile and increased numbers of CD8+ T cells and NK cells. Girls are more Th2-skewed and elicit more enhanced inflammatory responses. Non-immunological factors (including exposure intensity, behavior, and co-infections) may impact disease. However, given the consistent patterns seen across time and geography, these factors likely are less central. Strategies to protect children and adolescents from TB may need to differ by age and sex. Further work is required to better understand the contribution of age and sex to M. tuberculosis immunity.

show abstract

“…The reason why drug addiction can influence TB incidence is drug users’ way of life and injury of respiratory tract and decrease in immunity (Silva et al, 2018; Cruz et al, 2013; Kiboi et al, 2016). Factor D4 is significant only in models for 2005, but it is possible to assume, judging by correlation coefficients (from 0.272 in 2006-2009 up to 0.345 in 2014-2016) that further influence of D4 is shown indirectly through D2 ( t -1).…”

Section: Regression Analysis and Interpretation Of Resultsmentioning

confidence: 99%

Migration, Infectious Diseases and Drug Addiction in Russia

Lifshits

Neklyudova

2020

Preprint

View full text Add to dashboard Cite

The aim of the paper is to analyze the possible impact of various aspects of internal and external migration in regions of Russia on the prevalence of the following social dangerous diseases: HIV, active tuberculosis, syphilis, drug addiction, acute and chronic viral hepatitis B and C. We analyzed the papers that concern the impact of migration on the health of the host territory population. The main research methods are econometric and correlation analysis. We constructed panel models for each disease. The models tested various socioeconomic indicators (including education level, cash income, housing improvements and the incidence of alcoholism), as well as climatic, geographical and demographic indicators. Influence of disease incidence in the neighbouring regions is also considered. Five various indicators of migration were tested. They characterize labour immigration, internal and external migration inflows to the regions and share of people born outside the region. We tried to track changes of factors that influence spread of diseases over time. It allowed us to correct the conclusions drawn earlier. In the course of the research, positive significant statistical correlation of the following indicators of migration and disease incidence was established: 1) foreign citizens employment and incidence of syphilis in 2005; 2) share of internal migrants and incidence of drug addiction in 2005; 3) foreign citizens employment and incidence of drug addiction in 2006-2016; 4) foreign citizens inflow and detection of chronic viral hepatitis in 2010; 5) foreign citizens inflow and detection of acute hepatitis C in 2011-2016.

show abstract

Immunological Interactions of Tuberculosis with Drugs and Substance Use: A Systematic Review and Update

Cited by 7 publications

References 0 publications

Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of other drugs

Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of other drugs

The Wonder Years: What Can Primary School Children Teach Us About Immunity to Mycobacterium tuberculosis?

Migration, Infectious Diseases and Drug Addiction in Russia

Contact Info

Product

Resources

About