Immunomodulators Acting on COVID-19: Actual Knowledge and Perspectives

Abstract

<jats:p>Since the outbreak of SARS CoV-2 infection (Covid-19), healthcare professionals worldwide have been trying to find disease management and control alternatives to encourage immunotherapies. Immunotherapy is an efficient therapeutic option used against comparable viral contaminations such as MERS-CoV and SARS-CoV. The aim of the current study is to assess the existing knowledge associated with SARS-CoV-2 immunotherapy. Information available in published articles and their quality highlights the importance of following strict scientific rules for clinical outcomes. Thus, these studies have shown enough data to confirm that immunomodulation is the main topic investigated in research about Covid-19 therapy. Therefore, it is possible saying that immunotherapy is certainly the appropriate option against this virus.</jats:p>

Vitamin D, zinc and glutamine: Synergistic action with OncoTherad immunomodulator in interferon signaling and COVID‑19 (Review)

“…Notably, the other 4 patients subjected to the clinical protocol of OncoTherad therapy for NMIBC who tested positive for COVID-19 exhibited a similar outcome to that of the patient described in the aforementioned case report. Their recovery was more rapid (10 days) when compared to the observed for patients subjected to the standard treatment only (17).…”

“…In 5 patients who developed severe COVID-19 while undergoing treatment for NMIBC, the administration of OncoTherad with corticosteroids and antibiotics mitigated the exacerbated inflammatory response in the lungs, decreased the average hospital stay from 18 to 10 days, and prevented the need for intubation (17,84).…”

“…A study with 140 participants for the use of OncoTherad immunotherapy associated with standard clinical treatment for COVID-19 is underway at Hospital Municipal de Paulinia. The study is expected to last for 1 year (17).…”

“…These nutrients are referenced as potential adjuvants in the prevention and treatment of viral infections (6)(7)(8)(9). Moreover, emerging evidence provided in the literature has consistently highlighted the potential role of these nutrients, as well as the immunotherapeutic agent OncoTherad, in the prevention or therapy of COVID-19 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). The combination of these nutrients with OncoTherad aims to provide specific metabolic support that, when coordinated with their individual antiviral effects, may represent a putative therapeutic and/or preventive action against COVID-19.…”