Immunomodulatory effect of candesartan on indomethacin-induced gastric ulcer in rats

Kamel, Rehab; Morsy, Engy M. El; Awad, Azza S.

doi:10.3109/08923973.2012.698283

Cited by 9 publications

(6 citation statements)

References 32 publications

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“…Either candesartan or EGCG exhibited potent antioxidant activity and decreased gentamicin‐induced nephrotoxicity, which was verified by restoring the oxidative balance. There are different experimental studies which demonstrated their antioxidant effects …”

Section: Discussionmentioning

confidence: 99%

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Candesartan and epigallocatechin‐3‐gallate ameliorate gentamicin‐induced renal damage in rats through p38‐MAPK and NF‐κB pathways

Ahmed

Mohamed

2018

J Biochem & Molecular Tox

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This study pointed to estimate the possible protective impacts of candesartan and/or epigallocatechin‐3‐gallate (EGCG) against gentamicin‐induced nephrotoxicity. The current work revealed that gentamicin significantly elevated relative kidney weight and the serum level of creatinine and urea. Also, renal level of malondialdehyde was significantly increased with a concurrent decrease in renal glutathione‐S‐transferase and superoxide dismutase activities. Moreover, renal levels of nuclear factor‐kappa B (NF‐κB) and p38 mitogen‐activated protein kinase (p38‐MAPK) were increased together with the elevation of tumor necrosis factor‐alpha and interleukin‐1 beta levels after gentamicin treatment. In addition, caspase‐3 expression was elevated, and histological examination revealed extreme alterations enlightening inflammation, degeneration, and necrosis. Pretreatments with candesartan and/or EGCG attenuated gentamicin‐induced nephrotoxicity. Importantly, the altered expression of p38‐MAPK and NF‐κB may play a significant role in the protective mechanisms exerted by candesartan and EGCG. Coadministration of candesartan and EGCG exhibited more profound response compared with the monotherapy.

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Section: Discussionmentioning

confidence: 99%

“…There are different experimental studies which demonstrated their antioxidant effects. [38,[41][42][43][44] Inflammatory progression induced by gentamicin was evident also by the notable elevation in renal levels of key inflammatory cytokines;…”

Section: Discussionmentioning

confidence: 99%

Candesartan and epigallocatechin‐3‐gallate ameliorate gentamicin‐induced renal damage in rats through p38‐MAPK and NF‐κB pathways

Ahmed

Mohamed

2018

J Biochem & Molecular Tox

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“…CRP production is regulated by proinflammatory cytokines such as TNF-α, IL-1 and IL-6 [22]. Many researchers have reported that mucin levels are decreased in indomethacin-induced ulcers and TNF-α [5,[23][24][25][26][27] and IL-6 levels are increased [5,25,27]. Jafarzadeh et al (2009) reported that serum CRP level was higher in patients with peptic ulcer infected with Helicobacter pylori compared to healthy individuals [22].…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective effects of Taraxacum officinale (Dandelion) extract indomethacin-induced gastric ulcer model

Uslu¹,

Uslu²

2022

GSC Biol. Pharm. Sci.

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In this study, it was aimed to investigate the gastroprotective and anti-inflammatory effects of the extract (TO) obtain from the leaves of Taraxacum officinale, which is used in the treatment of many diseases including gastric ulcers in traditional medicine, in an indomethacin-induced gastric ulcer model. Forty rats, which 10 animals in each group, were divided into four groups (Control (C), TO + Indomethacin (TO+IND), Indomethacin (IND) and Omeprazole + Indomethacin (O+IND) groups). Respectively the group C was given isotonic saline, the group TO+IND was given 100 mg/kg TO extract, group IND was given isotonic saline and the group O+IND was given 5 mg/kg omeprazole orally. On the 11th day of the study, a single dose of 100 mg/kg indomethacin was administered orally to the TO+IND, IND and O+IND groups. It was determined that cyclooxygenase-2 (COX-2), C-reactive protein (CRP) and Interleukin-6 (IL-6) levels were significantly increased in the IND group compared to the K group (p<0.001). However, these markers were significantly decreased in both the TO+IND (respectively p<0.05, p<0.001, p<0.05) and O+IND (p<0.05, p<0.001, p<0.001, respectively) groups when compared with the IND group. No significant changes were observed in tumor necrosis factor-alpha (TNF-α) levels. Depending on the administration of indomethacin, it was found that the ulcer index of gastric tissue increased significantly compared to the C group but it decreased significantly as a result of TO and Omeprazole administrations (p<0.001). As a result, it was determined that Taraxacum officinale leaf extract showed significant gastroprotective effects by reducing COX-2, CRP and IL-6 levels and ulcerative area formation in gastric tissue.

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“…Increasing evidence suggests that inflammatory mediators may play a role in the development and progression of gastric ulcer. A lot of literature had reported that TNF-α, the Evidence-Based Complementary and Alternative Medicine main proinflammatory cytokine, was the important contributing factor in intestinal mucosal injury [9,30]. TNF-α is the initiator of the exogenous death pathway.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective Activity of the Total Flavones from Abelmoschus manihot (L.) Medic Flowers

Zhang

Chu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Abelmoschus manihot (L.) Medic flower is a medicinal plant for the treatment of diseases in China. e present study was carried out to scientifically validate the gastroprotective activity and clarify the possible mechanism of the total flavones from Abelmoschus manihot (L.) Medic flowers (TFA). Methods. Gastric ulcer was induced in mice by oral administration of ethanol. e gastroprotective activity of TFA was evaluated by the gastric ulcer index and histological examinations. e gastric tissue was collected in the form of homogenate. e level of malondialdehyde (MDA) and glutathione (GSH), the activity of superoxide dismutase (SOD), and protein content were measured. Western blotting for the expression of Bax, Bcl-2, TNF-α, and NF-κB(p65) was also carried out. e effect of TFA was compared with that of standard antiulcer drug omeprazole (100 mg/kg). Results. is gastroprotective effect of TFA could be attributed to the increase in the activity of SOD and GSH and decrease in the levels of MDA and also decrease in the levels of Bax, TNF-α, and NF-κB(p65) expressions and increase in the Bcl-2 expression level. Conclusion.e findings of this study demonstrated that TFA could significantly attenuate ethanol-induced gastric injury via antioxidative, anti-inflammatory, and antiapoptotic effects.

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Immunomodulatory effect of candesartan on indomethacin-induced gastric ulcer in rats

Cited by 9 publications

References 32 publications

Candesartan and epigallocatechin‐3‐gallate ameliorate gentamicin‐induced renal damage in rats through p38‐MAPK and NF‐κB pathways

Candesartan and epigallocatechin‐3‐gallate ameliorate gentamicin‐induced renal damage in rats through p38‐MAPK and NF‐κB pathways

Gastroprotective effects of Taraxacum officinale (Dandelion) extract indomethacin-induced gastric ulcer model

Gastroprotective Activity of the Total Flavones from Abelmoschus manihot (L.) Medic Flowers

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