Immunomodulatory Effect of Nigella sativa Oil on T Lymphocytes in Patients with Rheumatoid Arthritis

Kheirouri, Sorayya; Hadi, Vahid; Alizadeh, Mohammad

doi:10.3109/08820139.2016.1153649

Cited by 64 publications

(52 citation statements)

References 43 publications

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“…A clinical study recruited 24 patients with allergic rhinitis sensitive to house dust mites and 7 healthy volunteers, administered with conventional doses of allergen-specific immunotherapy for 30 days. After a month of immunotherapy, 12 patients among 24 received the 2 g/day oral supplementation of N. sativa seed for 30 days that resulted in significant raise of CD8 counts and polymorphonuclear leukocyte (PMN) along with improved clinical symptoms [ 47 ] and a randomized, double-blinded placebo-controlled clinical trial of 43 female patients with mild to moderate rheumatoid arthritis (RA) revealed that administration of capsules of 500mg N. sativa oil 2 times daily for 2 months resulted in modulation of T lymphocytes such as decreased CD8+ (suppressive lymphocyte), and increased percentage of CD4+CD25+ and the ratio of CD4+/CD8+ [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

Prophetic Medicine-Nigella Sativa (Black cumin seeds) – Potential herb for COVID-19?

Maideen

2020

J Pharmacopuncture

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Section: Resultsmentioning

confidence: 99%

Prophetic Medicine-Nigella Sativa (Black cumin seeds) – Potential herb for COVID-19?

Maideen

2020

J Pharmacopuncture

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“…Anecdotic reports suggest that immunological benefits can be gained in patients with autoimmune diseases including SLE and rheumatoid arthritis from simple measures, including oral honey drink and Nigella sativa oil 152 or powder as nutritional support measures. It is reported that wet cupping therapy (Al-Hijamah) can clear patients’ blood from autoantibodies, inflammatory mediators and immunological noxious substances.…”

Section: Third-line Treatmentsmentioning

confidence: 99%

Evans syndrome: clinical perspectives, biological insights and treatment modalities

Jaime‐Pérez¹,

Aguilar-Calderón²,

Salazar‐Cavazos³

et al. 2018

JBM

113

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Evans syndrome (ES) is a rare and chronic autoimmune disease characterized by autoimmune hemolytic anemia and immune thrombocytopenic purpura with a positive direct anti-human globulin test. It is classified as primary and secondary, with the frequency in patients with autoimmune hemolytic anemia being 37%–73%. It predominates in children, mainly due to primary immunodeficiencies or autoimmune lymphoproliferative syndrome. ES during pregnancy is associated with high fetal morbidity, including severe hemolysis and intracranial bleeding with neurological sequelae and death. The clinical presentation can include fatigue, pallor, jaundice and mucosal bleeding, with remissions and exacerbations during the person’s lifetime, and acute manifestations as catastrophic bleeding and massive hemolysis. Recent molecular theories explaining the physiopathology of ES include deficiencies of CTLA-4, LRBA, TPP2 and a decreased CD4/CD8 ratio. As in other autoimmune cytopenias, there is no established evidence-based treatment and steroids are the first-line therapy, with intravenous immunoglobulin administered as a life-saving resource in cases of severe immune thrombocytopenic purpura manifestations. Second-line treatment for refractory ES includes rituximab, mofetil mycophenolate, cyclosporine, vincristine, azathioprine, sirolimus and thrombopoietin receptor agonists. In cases unresponsive to immunosuppressive agents, hematopoietic stem cell transplantation has been successful, although it is necessary to consider its potential serious adverse effects. In conclusion, ES is a disease with a heterogeneous course that remains challenging to patients and physicians, with prospective clinical trials needed to explore potential targeted therapy to achieve an improved long-term response or even a cure.

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“…However, 2 studies in animal models [56,69] did not report any significant effect of N. sativa in RA. In addition, human studies [52][53][54][55][56] have suggested favorable effects of N. sativa on clinical and immunologic parameters of RA; however, no change or improvement of inflammatory and oxidative biomarkers was declared in the clinical trials [53,55]. The controversy in findings between clinical and experimental investigations may be attributed to the differences in the measures of inflammatory, oxidative, and anti-oxidative markers in vivo or in vitro, as well as intensity and the type of stimulators of inflammation and oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…The beneficial effects of N. sativa on RA prevention and treatment have been investigated in recent y, and some hopeful findings have been obtained from experimental investigations [46][47][48][49][50][51] and clinical trials [52][53][54][55][56]. It has been suggested that N. sativa can influence the main traits of RA via various procedures [57].…”

Section: A Systematic Review Of the Potential Effects Of Nigella Satimentioning

confidence: 99%

A Systematic Review of the Potential Effects of Nigella sativa on Rheumatoid Arthritis

et al. 2020

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Considering the different untoward effects of the drugs prescribed for the treatment of rheumatoid arthritis (RA), there has been an increasing interest in adjuvant therapies devoid of such unfavorable reactions. Although the beneficial effects of Nigella sativa (N. sativa) on RA have been established, it seems that its mechanisms of action have not still been reviewed. The present review is designed to evaluate the effects of N. sativa on RA systematically. We searched these electronic databases until April 2019: PubMed, Scopus, ISI Web of Science, Cochrane Library, Embase, Ovid, ProQuest, and Google scholar. No restriction was conducted based on language or publication date. We selected all of the related clinical, animal, and in vitro studies. Review papers, abstracts in conferences, book chapters, and papers regarding the effects of N. sativa combined with other herbs, as well as articles regarding the effects of N. sativa on other diseases, were excluded. Each article was assessed critically for the possible risk of bias. Nineteen articles were reviewed. Animal and in vitro investigations supported the favorable effects of N. sativa on clinical, inflammatory, oxidative, and immunologic parameters on RA, whereas results of limited clinical studies did not illustrate any change or improvement of inflammatory and oxidative biomarkers in RA. N. sativa could control RA via multiple ways such as decreasing inflammation, inhibiting oxidative stress, and modulating the immune system. This paper provides persuasive clues to defend the efficacy of N. sativa in RA and justifies the significance of subsequent clinical trials.

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Immunomodulatory Effect of Nigella sativa Oil on T Lymphocytes in Patients with Rheumatoid Arthritis

Abstract: This study gives strength to the potential relevance of NS in clinical management of RA through modulation of T lymphocytes.

Cited by 64 publications

References 43 publications

Prophetic Medicine-Nigella Sativa (Black cumin seeds) – Potential herb for COVID-19?

Prophetic Medicine-Nigella Sativa (Black cumin seeds) – Potential herb for COVID-19?

Evans syndrome: clinical perspectives, biological insights and treatment modalities

A Systematic Review of the Potential Effects of Nigella sativa on Rheumatoid Arthritis

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