Immunomodulatory influences of sialylated lactuloses in mice

Zeng, Jie; Song, Mengdi; Tian, Jia; Gao, Haiyan; Zhang, Ruiyao; Jiang, Jiajia

doi:10.1016/j.bbrc.2019.04.157

Cited by 7 publications

(3 citation statements)

References 24 publications

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“…When antigen appears in the blood, macrophages and lymphocytes in the spleen will have an immune response and swallow antigen, resulting in splenomegaly. Therefore, the changes in the spleen shape and spleen index can be used as an indicator to identify the sensitization effect ( 41 ). As shown in Figure 5 , the spleen index in the PN group was significantly increased compared with that in the CK group.…”

Section: Resultsmentioning

confidence: 99%

Optimized Extraction of cAMP From Jujube by Ultra-High Pressure Technology and the Anti-allergic Effect for Peanut Allergy Mouse

et al. 2022

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Jujube contains abundant cyclic adenosine monophosphate (cAMP). In contrast, the extraction technology of cAMP from jujube is still to be explored. In this study, the ultra-high pressure extraction (UHPE) conditions for obtaining the maximum cAMP yield from jujube were optimized. Orthogonal array design (OAD) was applied to evaluate the effects of three variables (pressure, pressure-holding time, and liquid-to-solid ratio) by UHPE on cAMP yield. The results showed that the optimal cAMP yield (1223.2 μg/g) was derived at 300 MPa, 20 min duration, and a liquid-to-solid ratio of 2.5 ml/g. In addition, as an important functional ingredient in jujube, cAMP has potential anti-allergic effect. To develop the functional characteristics of jujube, the effect of cAMP was characterized in vivo with the Balb/c mouse model of peanut allergy, which was established by subcutaneous injection of crude peanut protein extract (PN). The results showed that treatment with cAMP in PN-sensitized mice suppressed the lesions in jejunal tissues and allergic symptoms and restored spleen index. Meanwhile, cAMP treatment reduced serum levels of specific immunoglobulin E (IgE), histamine, as well as interleukin-4 (IL-4) and stimulated the secretion of tumor necrosis factor-α (TNF-α), whereas the serum levels of interleukin-10 (IL-10) were not affected. Our results suggested that cAMP has an anti-allergic effect in PN-sensitized mice.

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Section: Resultsmentioning

confidence: 99%

Optimized Extraction of cAMP From Jujube by Ultra-High Pressure Technology and the Anti-allergic Effect for Peanut Allergy Mouse

et al. 2022

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“…Specially, the regulation of the sialylated lactulose on intestinal microecology were accompanied by the improvement of immunity. Comparing with control group, the IgA and IgM contents of spleen were raised by 49.05% and 47.25%, and the phagocytic percentage and phagocytic index were greatly higher in KDN-α2,3-lactulose treated group [ 53 , 113 ]. Prebiotics can be acted as the bioactive components and impart various physiological benefits on human health.…”

Section: Broad Impact Of Sa On the Gut Microbiome And Functionmentioning

confidence: 99%

Insights into the Structure, Metabolism, Biological Functions and Molecular Mechanisms of Sialic Acid: A Review

Li,

Lin,

Luo

et al. 2023

Foods

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Sialic acid (SA) is a kind of functional monosaccharide which exists widely in edible bird’s nest (EBN), milk, meat, mucous membrane surface, etc. SA is an important functional component in promoting brain development, anti-oxidation, anti-inflammation, anti-virus, anti-tumor and immune regulation. The intestinal mucosa covers the microbial community that has a significant impact on health. In the gut, SA can also regulate gut microbiota and metabolites, participating in different biological functions. The structure, source and physiological functions of SA were reviewed in this paper. The biological functions of SA through regulating key signaling pathways and target genes were discussed. In summary, SA can modulate gut microbiota and metabolites, which affect gene expressions and exert its biological activities. It is helpful to provide scientific reference for the further investigation of SA in the functional foods.

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“…Presently, the well-known prebiotics involve non-digestible carbohydrates, such as FOS, GOS, inulin, and lactulose [13][14][15][16]. Additionally, other non-digestible carbohydrates, such as arabinoxylan, beta-glucans, isomalto-oligosaccharides (IMO), polydextrose, soybean oligosaccharides, XOS, and xylo-polysaccharide (XPS), have also been claimed to exhibit prebiotic potential based on clinical evidence [17], although most scientific literature available concerning prebiotic potential is related to FOS and inulin [18].…”

Section: What Are Prebiotics?mentioning

confidence: 99%

Plant Prebiotics and Their Role in the Amelioration of Diseases

et al. 2021

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Prebiotics are either natural or synthetic non-digestible (non-)carbohydrate substances that boost the proliferation of gut microbes. Undigested fructooligosaccharides in the large intestine are utilised by the beneficial microorganisms for the synthesis of short-chain fatty acids for their own growth. Although various food products are now recognized as having prebiotic properties, several others, such as almonds, artichoke, barley, chia seeds, chicory, dandelion greens, flaxseeds, garlic, and oats, are being explored and used as functional foods. Considering the benefits of these prebiotics in mineral absorption, metabolite production, gut microbiota modulation, and in various diseases such as diabetes, allergy, metabolic disorders, and necrotising enterocolitis, increasing attention has been focused on their applications in both food and pharmaceutical industries, although some of these food products are actually used as food supplements. This review aims to highlight the potential and need of these prebiotics in the diet and also discusses data related to the distinct types, sources, modes of action, and health benefits.

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Immunomodulatory influences of sialylated lactuloses in mice

Cited by 7 publications

References 24 publications

Optimized Extraction of cAMP From Jujube by Ultra-High Pressure Technology and the Anti-allergic Effect for Peanut Allergy Mouse

Optimized Extraction of cAMP From Jujube by Ultra-High Pressure Technology and the Anti-allergic Effect for Peanut Allergy Mouse

Insights into the Structure, Metabolism, Biological Functions and Molecular Mechanisms of Sialic Acid: A Review

Plant Prebiotics and Their Role in the Amelioration of Diseases

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