Immunopathogenesis of Graves’ Disease

Rapoport, Basil; McLachlan, Sandra M.

doi:10.1007/978-1-4939-2534-6_2

Cited by 6 publications

(7 citation statements)

References 85 publications

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“…However, GD is mainly characterized by autoantibodies produced by B cells infiltrated into the thyroid gland against the thyroid follicular cell thyrotropin receptor (TSH-R). [10][11][12] It was also shown that TH1 cells and their related chemokine receptors r (C-X-C)R3 receptor have a pivotal role in the pathogenesis of GD. 13 Tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) inflammatory cytokines play a part in inflammatory immune responses.…”

Section: Immunopathogenesis Of Aitmentioning

confidence: 99%

Low-Level Laser Therapy in the Treatment of Autoimmune Thyroiditis

2022

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Introduction: Autoimmune thyroiditis (AIT) is an autoimmune disorder that is characterized by thyroid gland dysfunction. Low-level laser therapy (LLLT), as a safe and non-invasive intervention, has gained much attention in many clinical applications including pain relief, regenerative medicine, and autoimmune.Methods: In this review, we discuss the effect of LLLT on cellular responses and its application in the treatment of AIT. Such keywords as "low-level laser therapy", "photobiomodulation" and "autoimmune thyroiditis" were used to find studies related to laser therapy in AIT in Google Scholar, PubMed and Medline databases. Results: LLLT reduced thyroid gland inflammation and inhibited immune cell trafficking. LLLT modulated inflammatory responses and improved thyroid gland regeneration.Conclusion: Investigations indicated that besides current treatment strategies, LLLT could be a promising therapeutic approach for the treatment of AIT.Keywords: Low-level laser therapy (LLLT); Photobiomodulation; Autoimmune thyroiditis; Laser

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Section: Immunopathogenesis Of Aitmentioning

confidence: 99%

Low-Level Laser Therapy in the Treatment of Autoimmune Thyroiditis

2022

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“…Фолликулярные тироциты могут подвергаться воздействию цитокинов, продуцируемых как лимфоцитами, так и самими тироцитами. В экспериментах in vitro установлено, что ФНО-α и Ил-1α подавляют как базальную, так и стимулированную тиреотропным гормоном экспрессию НйС, а интерферон-γ способен оказывать аналогичный эффект, но в значительно более высоких концентрациях [24]. ТФР-β, Ил-1β и Ил-6 также снижали экспрессию гена НйС, но Ил-1β подавлял также транспорт йодидов в клетки, в то время как Ил-6 не влиял на этот процесс [25,26].…”

Section: влияние цитокинов на экспрессию нйс фолликулярными тироцитамиunclassified

“…Это дало основание выдвинуть гипотезу о способности НйС быть аутоантигеном, наряду с тиреопероксидазой и тироглобулином, и мишенью для цитотоксических лимфоцитов. Более того, у пациентов с аутоиммунными заболеваниями щитовидной железы в крови выявлялись антитела, способные связываться с НйС и ингибировать его функцию [24,28,29].…”

Section: влияние цитокинов на экспрессию нйс фолликулярными тироцитамиunclassified

Impact of Na+/I– symporter to non-oncologic pathology of the thyroid

Цомартова¹,

Chereshneva²,

Ivanova³

et al. 2019

Medical news of the North Caucasus

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“…Thyrotoxicosis and autoreactive lymphocytes in the thyroid gland are clinical features of Graves' disease. Graves' illness is characterized by hyperthyroidism in 60-90% of patients; it was often accompanied by anxiety, weight loss, bulging eyes, enlarged thyroid gland, heat sensitivity, nervousness, and hand and finger tremors (3) (4) .…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Correlation Between Vitamin D and T3, T4, FT3, FT4 and TSH Among Patients with Graves' Disease

Ali¹,

Hamoud²

2022

PJMHS

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Background: Graves' disease is characterized by a diffuse hyperfunctional goiter that develops suddenly and is linked to an immune thyroid stimulating factor. Graves' disease hyperthyroidism is caused by circulating IgG antibodies binding to and activating the G-protein–coupled thyrotropin receptor. This activation causes thyroid enlargement by stimulating follicular hypertrophy and hyperplasia, as well as increases in thyroid hormone synthesis. Objectives: This study aims to assess the Determination the concentration of vitamin D in patients with graves diseases, Measurement T3, T4, FT3, FT4 and TSH hormones and Determination the correlation between immunological markers by the (SPSS). Materials and Methods: This research included a total of (90) people of various sexes and ages (30 men and 60 females), including (60) Graves' disease patients and (30) healthy people. Patients with Graves' disease were seen at Alsader Medical City (Najaf Center for Diabetes and Endocrinology). Between November 2021 and January 2022. Results: In this research, the levels of (T3, T4, TSH, FT3 and FT4) hormones and Vitamin D revealed a very significant association (P.value> 0.005) across the groups tested. A non-significant association was also found between vitamin D and other variables. According to the patients' group, the FT3 revealed a strong negative connection with vitamin D in comparison to the other parameters. Conclusion: The Thyrotropin receptor antibody (TRAb) test and ultrasonography of the thyroid gland are useful diagnostic tools for autoimmune Graves' disease. Grave's disease is connected with decreased vitamin D levels in the blood and could be made worse by high serum levels of T3, T4, FT3, FT4, and TRAb-positive and a low serum level of TSH.

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Immunopathogenesis of Graves’ Disease

Cited by 6 publications

References 85 publications

Low-Level Laser Therapy in the Treatment of Autoimmune Thyroiditis

Low-Level Laser Therapy in the Treatment of Autoimmune Thyroiditis

Impact of Na+/I– symporter to non-oncologic pathology of the thyroid

Assessment of the Correlation Between Vitamin D and T3, T4, FT3, FT4 and TSH Among Patients with Graves' Disease

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