Immunoreactive cutaneous sporotrichosis

Carvalho, Gustavo de Sá Menezes; Veasey, John Verrinder

doi:10.1016/j.abd.2019.11.015

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…The clinical manifestations are varied, from localized to disseminated infection, such as the cutaneous and extracutaneous lymphatic forms. Between 80% and 95% of cases are cutaneous lymphatic sporotrichosis, which spreads through the lymph nodes, occurring mainly on the face, upper and lower limbs [1][2][3]6 . These manifestations result from several factors, such as the host's immune response, the virulence of the fungal isolate, the amount of inoculum and the depth of inoculation 1,6 .…”

Section: Introductionmentioning

confidence: 99%

“…Between 80% and 95% of cases are cutaneous lymphatic sporotrichosis, which spreads through the lymph nodes, occurring mainly on the face, upper and lower limbs [1][2][3]6 . These manifestations result from several factors, such as the host's immune response, the virulence of the fungal isolate, the amount of inoculum and the depth of inoculation 1,6 . In humans and other mammals, the main route of entry is through the skin, traumatized by injury with material contaminated by the fungus.…”

Section: Introductionmentioning

confidence: 99%

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Clinical-epidemiological characteristics of Sporotrichosis cases in Rio Grande do Sul, Brazil: a 16-year study

Moraes¹,

Koehler²,

Venier³

et al. 2023

Braz. J. Hea. Rev.

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Background: Sporotrichosis is a subcutaneous fungal infection that occurs worldwide, although its highest incidence is in tropical and subtropical areas. In Brazil, it is an hyperendemic disease that affects animals and humans. Objective: To report cases of sporotrichosis in a dermatology referral service, in the state of Rio Grande do Sul. Methods: Retrospective, observational, descriptive study, from 2003 to 2019. Data were selected from patients who had skin lesions suggestive of sporotrichosis, and who had positive direct and/or cultural mycological examinations of Sporothrix spp.. Clinical records were reviewed in charts. Results: 61 cases of sporotrichosis were identified, with an annual average of 4 cases. There was a predominance of males (54.1%; n=33) and white skin color (77.0%; n=47). The mean age was 45.9 years (standard deviation = 21.2), with the predominant age group between 25 and 60 years (41.0%; n=25). The sample consisted mainly of patients residing in the interior of the state of Rio Grande do Sul (47.5%; n=29). Conclusions: This study contributes with updates on the epidemiological situation of sporotrichosis in the state of Rio Grande do Sul.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical-epidemiological characteristics of Sporotrichosis cases in Rio Grande do Sul, Brazil: a 16-year study

Moraes¹,

Koehler²,

Venier³

et al. 2023

Braz. J. Hea. Rev.

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“…In the extracutaneous or disseminated forms, other organs and systems are involved. 8,10 Recent literature reported an increased in extraocular (granulomatous conjunctivitis), 11,12 and immunoreactive clinical forms 13,14 in patients with sporotrichosis transmitted by cats. 15 In addition, atypical and more severe manifestations of sporotrichosis have been associated with S. brasiliensis.…”

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Clinical factors associated with systemic sporotrichosis in Brazil

Magalhães,

Colombo,

Peres

et al. 2023

Mycoses

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BackgroundSystemic sporotrichosis occurs when organs, other than subcutaneous tissues and lymph nodes, are infected. Interestingly, systemic sporotrichosis in apparently immunocompetent individuals is increasing in Brazil, but data on clinical manifestations and risk factors are scarce. Most of the existing data on such condition relate to people living with HIV. We aimed to study the risk factors associated with systemic sporotrichosis among HIV‐negative and HIV‐positive patients.MethodsWe performed a retrospective cross‐sectional study with 80 patients from Brazil, diagnosed between 2014 and 2021. The association between disease classification, clinical presentation and risk factors were analysed by logistic regression.ResultsOf the 80 patients, 29 (36.3%) presented with systemic sporotrichosis. All HIV‐positive patients developed the systemic form, with increased mortality (p = .002). Alcohol ingestion (p = .009) and diabetes (p = .010) were associated with systemic disease. Alcohol ingestion seemed to favour pulmonary infection (p = .013) and, diabetes favoured osteoarticular (p = .009) and ocular involvement (p = .033). The occurrence of fever (p = .001) and weight loss (p = .006) were significantly associated with systemic sporotrichosis, while meningeal involvement (p = .001) increased mortality risk. Nine (11.3%) patients died from sporotrichosis. The presence of fungal structures in the mycological examination of the patients' lesions were associated with the systemic form (p = .017) and death (p = .002).ConclusionOur study points to the factors that drive systemic sporotrichosis other than HIV, such as alcohol ingestion and diabetes. Considering the high number of patients presenting severe sporotrichosis, the recognising these factors may contribute to timely diagnosis and proper treatment.

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Cutaneous and subcutaneous fungal infections: recent developments on host–fungus interactions

Wang

2021

Current Opinion in Microbiology

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Immunoreactive cutaneous sporotrichosis

Cited by 7 publications

References 7 publications

Clinical-epidemiological characteristics of Sporotrichosis cases in Rio Grande do Sul, Brazil: a 16-year study

Clinical-epidemiological characteristics of Sporotrichosis cases in Rio Grande do Sul, Brazil: a 16-year study

Clinical factors associated with systemic sporotrichosis in Brazil

Cutaneous and subcutaneous fungal infections: recent developments on host–fungus interactions

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