Immunoregulatory Function of HLA-G in Gastric Cancer

Tuncel, Tolga; Karagöz, Bülent; Haholu, Aptullah; Ozgun, Alpaslan; Emirzeoglu, Levent; Bilgi, Oğuz; Kandemir, Emin Gökhan

doi:10.7314/apjcp.2013.14.12.7681

Cited by 47 publications

(46 citation statements)

References 12 publications

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“…Ample evidence indicated that upregulation of the HLA-G in tumor cells is involved in every phase of cancer immunoediting including elimination, equilibrium and escape (32). For example, HLA-G was reported associated with immune escape in GC (33). The effects of HLA-G on immune cells greatly affect both innate and adaptive immune responses, allowing the HCC to escape host immunity, resulting in tumor progression (34).…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA HOTAIR modulates HLA-G expression by absorbing miR-148a in human cervical cancer

Sun

Chu

et al. 2016

International Journal of Oncology

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Abstract. The long non-coding RNA HOX transcript antisense RNA (HOTAIR) has been found overexpressed in many human malignancies and involved in tumor progression and metastasis. However, little is known about the potential biological roles of HOTAIR in tumor escape. In the present study, the expression of HOTAIR was detected in 59 paired cervical cancer tissue samples by real-time PCR and then subjected to correlation analysis with clinical features. The effects of HOTAIR on cervical cancer cells as well as the expression of human leukocyte antigen (HLA)-G were studied by overexpression and RNA interference approaches. Insight into the mechanism of HOTAIR acting as competitive endogenous RNAs (ceRNAs) was gained from bioinformatic analysis and luciferase assays. HOTAIR expression was obviously increased in cervical cancer tissue. HOTAIR upregulation was associated with advanced pathological stage, histology, lymph node invasion and lymphatic metastasis, and also correlated with shorter overall survival of cervical cancer patients. Furthermore, HOTAIR overexpression promoted the proliferation, migration and invasion of cervical cancer cells, while HOTAIR knockdown inhibited cell invasion and cell viability, induced apoptosis and inhibited growth in vitro and in vivo. Moreover, HOTAIR modulated human leucocyte antigen-G (HLA-G) expression by competitively binding miR-148a. Our data suggest that HOTAIR plays an important oncogenic role in cervical cancer and might serve as a marker for cervical cancer prognosis and a potential target for therapeutic intervention.

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Section: Discussionmentioning

confidence: 99%

Long non-coding RNA HOTAIR modulates HLA-G expression by absorbing miR-148a in human cervical cancer

Sun

Chu

et al. 2016

International Journal of Oncology

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“…However, more studies on the complete HLA-G gene and its linkage disequilibrium with other genes and on HLA-G expression at both the tumor site and plasma in a specific microenvironment are required to consolidate these findings. carcinoma (69,70), esophageal squamous cell carcinoma (71)(72)(73)(74), gastric cancer (75)(76)(77), glioblastoma (78), hepatocellular carcinoma (79)(80)(81), lung cancer (82)(83)(84), nasopharyngeal carcinoma (85), oral cavity squamous cell carcinoma (86), ovarian cancer (87-89), pancreatic adenocarcinoma (90), thyroid carcinoma (91,92). These data were summarized in Table 1.…”

Section: Relevance Of Hla-g Expression In Cancersmentioning

confidence: 99%

Human Leukocyte Antigen-G (HLA-G) Expression in Cancers: Roles in Immune Evasion, Metastasis and Target for Therapy

Lin

Yan

2015

Mol Med

109

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Aberrant induction of human leukocyte antigen-G (HLA-G) expression has been observed in various malignancies and is strongly associated with tumor immune escape, metastasis and poor prognosis. To date, great achievements have been made in understanding the underlying mechanisms of HLA-G involved in tumor progression. HLA-G could lead to tumor evasion by inhibition of immune cell cytolysis, differentiation and proliferation and inhibition of cytokine production, induction of immune cell apoptosis, generation of regulatory cells and expansion of myeloid-derived suppressive cells and by impairment of chemotaxis. Moreover, HLA-G could arm tumor cells with a higher invasive and metastatic potential with the upregulation of tumor-promoting factor expression such as matrix metalloproteinases (MMPs), indicating that ectopic HLA-G expression could render multiple effects during the progression of malignancies. In this review, we summarized the mechanisms of HLA-G involved in promoting tumor cell immune escaping, metastasis and disease progression. Special attention will be paid to its significance as an attractive therapeutic target in cancers.

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“…HLA-G appears to play a role in the suppression of immune responses and contribute to long-term immune escape or tolerance. HLA-G expression can be induced in different diseases including cancers (Elliott et al, 2011;Tuncel et al, 2013).…”

Section: -Bp Insertion/deletion Polymorphism Of the Hla-g Gene In Bmentioning

confidence: 99%

14-bp Insertion/Deletion Polymorphism of the HLA-G gene in Breast Cancer among Women from North Western Iran

Haghi

Feizi²,

Sadeghizadeh³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The human leukocyte antigen-G (HLA-G) gene is highly expressed in cancer pathologies and is one strategy used by tumor cells to escape immune surveillance. A 14-bp insertion/deletion (InDel) polymorphism of the HLA-G gene has been suggested to be associated with HLA-G mRNA stability and the expression of HLA-G. The aim of present study was to assess any genetic association between this polymorphism and breast cancer among Iranian-Azeri women. Materials and Methods: In this study 227 women affected with breast cancer, in addition to 255 age-sex and ethnically matched healthy individuals as the control group, participated. Genotyping was performed using polymerase chain reaction and electrophoresis assays. The data were compiled according to the genotype and allele frequencies, compared using the Chi-square test. Statistical significance was set at P<0.05. Results: In this case-control study, no significant difference was found between the case and control groups at allelic and genotype levels, although there is a slightly higher allele frequency of HLA-G 14bp deletion in breast cancer affected group. However,when the stage I subgroup was compared with stage II plus stage III subgroup of affected breast cancer, a significant difference was seen with the 14 bp deletion allele frequency. The stage II-III subgroup patients had higher frequency of deletion allele (57.4% vs 45.8%) than stage I cases (χ2=4.16, p-value=0.041). Conclusions: Our data support a possible action of HLA-G 14bp InDel polymorphism as a potential genetic risk factor for progression of breast cancer. This finding highlights the necessity of future studies of this gene to establish the exact role of HLA-G in progression steps of breast cancer.

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Immunoregulatory Function of HLA-G in Gastric Cancer

Cited by 47 publications

References 12 publications

Long non-coding RNA HOTAIR modulates HLA-G expression by absorbing miR-148a in human cervical cancer

Long non-coding RNA HOTAIR modulates HLA-G expression by absorbing miR-148a in human cervical cancer

Human Leukocyte Antigen-G (HLA-G) Expression in Cancers: Roles in Immune Evasion, Metastasis and Target for Therapy

14-bp Insertion/Deletion Polymorphism of the HLA-G gene in Breast Cancer among Women from North Western Iran

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