Immunorestoration of old mice by injection of thymus extract: Enhancement of T cell-T cell cooperation in the in vitro antibody response

D’Agostaro, Giacomo; Frasca, Daniela; Garavini, Mauro; Doria, Gino

doi:10.1016/0008-8749(80)90439-6

Cited by 22 publications

(3 citation statements)

References 18 publications

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“…One function of the thymus thought to be important in T cell differentiation is the production of thymic hormones 45 . Injection of purified thymic hormones, including thymosin, thymopoietin, and thymulin, into aged animals and humans does somewhat improve several parameters of immune function, including the activity of antigen‐specific helper T cells, the generation of specific antibody responses, and alloreactive cytolytic cells 46–50 …”

Section: Effect Of Interleukin‐2 On In Vitro Responses Of Young Adumentioning

confidence: 99%

Role of Interleukin‐2 in the Age‐Related Impairment of Immune Function

Thoman

1985

J American Geriatrics Society

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Section: Effect Of Interleukin‐2 On In Vitro Responses Of Young Adumentioning

confidence: 99%

Role of Interleukin‐2 in the Age‐Related Impairment of Immune Function

Thoman

1985

J American Geriatrics Society

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“…In the same way. D'Agostaro et al [8] pointed out that it produced an increase in Th Thymostimulin: An Immunoreslorativc Therapy in Surgery activity through maturation of T cell precur sors of old mice.…”

Section: Discussionmentioning

confidence: 99%

Immunorestorative Effect of Thymostimulin on Surgery Immunodepression: Experimental Model

García-Lechuz

Navarro²,

Morandeira³

et al. 1993

Eur Surg Res

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The purpose of the present study is to ascertain the immunorestorative effect of two different drugs on immunodepression induced by small bowel surgical resection in an experimental model. The potential immunorestorative effect has been measured by the ability of the drug to avoid the delay of skin allograft rejection induced by surgery and the inhibition of CD4/CD8 index changes induced by surgery in spleen tissue. 120 Wistar-Furth rats (age 12–16 weeks) anesthetized with a single intramuscular dose of ketamine (25 mg), diazepine (4 mg) and atropine (0.1 mg) were allotted to two main groups. One group received a skin graft (SG) from Fisher 344 rats and was treated with placebo, Inmunoferón® (AM-3 polypeptidic drug) or TP-II (thymostimulin) before the experiment (groups I, II, III) or treated with placebo, Inmunoferón or TP-1 before the experiment and underwent enterectomy and anastomosis (groups IV, V, VI). On the 2nd, 5th and 8th postoperative days, biopsies of the SG were taken and the signs of rejection were microscopically studied and evaluated by a pathologist as zero, incipient, moderate or massive. The other group was treated similarly, but the animals did not receive a SG and were splenectomized 5 days later. CD4 and CD8 lymphocyte subpopulations were identified by means of immunoperoxidase technique and monoclonal antibodies. Thymostimulin is able to stimulate the presence of SG rejection signs on the 2nd postoperative day in nonenterectomized animals and on the 8th postoperative day in enterectomized rats and is able to avoid the decrease of the CD4/CD8 index in spleen tissue after surgical immunodepression. AM-3 has less effect on the presence of SG rejection signs and CD4/CD8 index than thymostimulin.

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“…Reported values have been niulliplied by 11)'. Previous expcrimenis have demonstrated that helper activity of primed spleen cells is mediated by T celts and not by B cells or macrophages, nor is it influenced by Tcells of the unprimed spleen cell population [31]. Furthcniiore.…”

Section: Induction and Tilration Of Th Cell Octivitymentioning

confidence: 97%

Effect of synthetic thymic humoral factor (THF-γ2) on T cell activities in immunodeficient ageing mice

Goso

Frasca

Doria

1992

Clinical and Experimental Immunology

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SUMMARYImtntinodeficicnl ageing (C57BL/10 x DBA/2)FI mice were treated by a single injection of synthetic thymic honnotics and 4 days laicr their thyintis and spleen cells were assayed in vitro for T cell activities. A tew nanograms ol'THK-v^ were found to raise the frequency of mitogen-responsive T cells in thymus and spleen cell poptilations as well as the frequency of cytokine-producing splenic T cells, up to the levels observed in young mice. Moreover, injection orTHF-72 was found lo restore Tcell growth factor (TCGF) prod tict ion by miiogcn-stimulaled spleen cells. Also, the helper acliviiy of spleen eells was enhanced by this treatment and increased wilh increasing the THl''--;2 dose over it wide range. Similarly, ihc elVects oCthymopentin and thymosin-xl on T helper cell aetivity increased with increasing the injected dose, but thceflicicncicsof THF-72and thymopentin were, respectively, 4()(J-rold and eight-fold greater than tha( of Ihyniosin-xl.

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Immunorestoration of old mice by injection of thymus extract: Enhancement of T cell-T cell cooperation in the in vitro antibody response

Cited by 22 publications

References 18 publications

Role of Interleukin‐2 in the Age‐Related Impairment of Immune Function

Role of Interleukin‐2 in the Age‐Related Impairment of Immune Function

Immunorestorative Effect of Thymostimulin on Surgery Immunodepression: Experimental Model

Effect of synthetic thymic humoral factor (THF-γ2) on T cell activities in immunodeficient ageing mice

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