Immunostimulating effects of sugar cane extract on X-ray radiation induced immunosuppression in the chicken

Amer, Said; Na, Ki-Jeong; El-Abasy, Moshira; Motobu, Maki; Koyama, Yukari; Koge, Kenji; Hirota, Yoshikazu

doi:10.1016/j.intimp.2003.10.006

Cited by 26 publications

(27 citation statements)

References 22 publications

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“…Results showed no difference in administered and control groups. These results were in accordance to the report of Amer et al (2004) who reported a non-significant Growth promoting effects of beta-glucans were evaluated with respect to feed efficiency ratios and body weight gains on weekly basis from week 1 st to 5 th post administration of wheat derived purified beta-glucans. The results showed higher live body weights in chickens administered with vitamin-E and beta-glucans as compared to control group (PBS; -ve control) of chickens, indicating better feed utilization in experimental groups.…”

Section: Discussionsupporting

confidence: 91%

“…The results are also consistent to the previous findings of similar studies on plant derived polysaccharides where orally administered chickens with beta-glucans resulted in higher antibody response against SRBCs (El-Abasy et al, 2003). Enhanced humoral response in terms of increased number of antibody-producing cells and higher serum antibody levels were observed in radiation induced immunocompromised chickens administered with plant extracts (Amer et al, 2004). Similarly, wheat derived polysaccharides showed stimulatory effects on the production of antibodies (Akhtar et al, 2008).…”

Section: Discussionsupporting

confidence: 91%

“…El-Abasy et al (2002; also demonstrated the related conclusion with higher body weights and lower feed utilization in plant administered groups as compared to control. Similar findings were also reported in immunosuppressed chickens exposed to X-ray radiation (Amer et al, 2004). Overall, the results of the present study suggest that beta-glucans (purified) may be responsible for the improvement of food utilization with higher weight gains.…”

Section: Discussionsupporting

confidence: 91%

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Immunological and Therapeutic Evaluation of Wheat (Triticum aestivum) Derived Betaglucans against Coccidiosis in Chicken

Rizwan¹,

Khan²,

Iqbal³

et al. 2016

IJAB

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To cite this paper: Rizwan, H.M., M.K. Khan, Z. Iqbal and F. Deeba, 2016. Immunological and therapeutic evaluation of wheat (Triticum aestivum) derived beta-glucans against coccidiosis in chicken. AbstractThis study was carried out to determine the immunomodulatory and therapeutic effects of wheat derived beta-glucans (purified) against avian coccidiosis. Briefly, beta-glucans from wheat bran were extracted and purified using standard procedures. A total of 250 broiler chicks (day-old) were reared at experimental station, Department of Parasitology, University of Agriculture, Faisalabad for this study. At 7 th day of their age, birds were subdivided into five equal groups (n=50). Groups A, B and C were orally administered with graded doses of purified beta-glucans (50, 100 and 150 mg/kg of body weight) for three consecutive days; whereas, positive control (group D) was administered with vitamin-E at the dose rate of 87mg/kg; while negative control (group E) was served with phosphate buffered saline (PBS solution). At 14 th day post administration of graded doses, 30 chickens from each group were randomly selected and used to monitor cellular and humoral immune responses, while remaining birds (n=20) in each group were challenged with mixed species of genus Eimeria for therapeutic evaluation. Overall, chickens in group A administered with 50 mg/kg b.wt. purified beta-glucans showed significantly higher immune responses in terms of enhanced humoral and cell mediated immunity as compared to those of other beta-glucans administered and E groups. While, the immune responses showed by group A were comparable with group D. After challenge with Eimeria, the groups A and D also showed maximum weight gains with low oocyst counts and maximum percent protection against lesions in both caecum and intestine. On the other hand, a minimum daily weight gain with increased number of oocysts in chickens was observed in control group (PBS) during therapeutic evaluation. These findings suggest that the beta-glucans derived from wheat may have immunomodulatory and therapeutic effects against Eimeria infection in chickens.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Immunological and Therapeutic Evaluation of Wheat (Triticum aestivum) Derived Betaglucans against Coccidiosis in Chicken

Rizwan¹,

Khan²,

Iqbal³

et al. 2016

IJAB

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“…In vitro study also reveals that SCE can significantly increase numbers and phagocytic function of polymorphonuclear cells [11]. Moreover, SCE can rescue the cell-mediated and humoral immunity in immune suppressed chickens that have been pretreated with x-irradiation [2] or cyclophosphamide [8]. These results indirectly suggest that SCE has positive effect on the activation of B and T cells, and polymorphonuclear cells, and the displays protective and adjuvant effects against infections.…”

Section: Discussionmentioning

confidence: 84%

Effects of Sugar Cane Extract on Pseudorabies Virus Challenge of Pigs

Dan-Yuan

Chien

Yeh

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. This experiment aimed to evaluate the efficacy of sugar cane extract (SCE) on the modulation of porcine immunity against pseudorabies virus (PrV) infection. Twelve-week-old experimental pigs were fed with SCE (500 mg/kg of body weight per day) for 3 days and challenged with PrV (2 × 10 5 TCID 50 ) on the second day. Pigs that were only challenged with PrV and without SCE-treatment served as controls. The leukocyte functional assays were performed on the 7th and 14th day post-PrV challenge. Our results showed a significant enhancement (P<0.05) of natural killer cytotoxicity, lymphocyte proliferation, phagocytic function of monocytes, and interferon-gamma (IFN-γ) production of CD4 + and γδ T cells in the SCE-treated pigs compared with the controls. In addition, SCE administration reduced the severity of clinical signs and brain lesion in the course of disease in PrV-challenged pigs. SCE-treated pigs showed a 12% growth enhancement compared with untreated controls. SCE administration had an immunostimulating effect on porcine immunity that may subsequently enhance protective activities against PrV infection which may be extensively applied in field for the prevention of infections. KEY WORDS: immunomodulation, interferon-gamma, leukocyte function, pseudorabies, sugar cane extract.J. Vet. Med. Sci. 68(3): 219-225, 2006 In recent years, porcine respiratory disease complex (PRDC) has become the major problem in most intensive pig farms causing massive economic loss. The causes of PRDC involve a complicated synergistic interaction between host immunocompetence, pathogens, and various stressors arising from the environment and management [28]. Pseudorabies virus (PrV) has been recognized as one of the most important primary pathogens for PRDC in fattening pigs [5,13,28] and antibiotics are commonly used to prevent secondary bacterial infections. As the abuse of antibiotics in veterinary medicine has been of particular concern from the viewpoint of public health, besides vaccination, major strategies against PRDC are to improve the managerial systems and environmental conditions and to modulate host immunocompetence.Sugar cane extract (SCE) is a natural product, which has displayed a wide range of biological effects including immunostimulation [11], anti-inflammatory activity [19], activity as a vaccine adjuvant [10], and anti-stress effects [4]. Studies on chickens indicate that SCE acts as an adjuvant and has a protective effect against Eimeria tenella infection [9]. Other effects of SCE including antibacterial activities [1,25], resistance to cold stress, and superoxide anion scavenging activity [26] have been reported. These results suggest that SCE can activate and enhance host natural immunity against infections. Our recent report also indicates that SCE can up-modulate porcine immunity, particularly in the enhancement of natural killer cytotoxicity which plays an important role in early viral infections [21]. Therefore, we are interested in elucidating the immunomodulatory function of SCE against vira...

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“…3) We have also demonstrated that our sugar cane extract (SCE) had an adjuvant effect on the activation of antibody and cell-mediated immune responses, 4,5) a protective effect against Eimeria tenella infection, 6) a radioprotective effect on immune functions and intestinal damage in X-ray irradiated chickens, 7,8) and a reconstituting effect on the bursa-dependent immune system in the immunosuppression experimentally induced by injecting cyclophosphamide into chickens. 9) Tumor necrosis factor (TNF)-induces various biological responses including tissue injury, shock and apoptosis.…”

mentioning

confidence: 90%

Reduced Lipopolysaccharide (LPS)-Induced Nitric Oxide Production in Peritoneal Macrophages and Inhibited LPS-Induced Lethal Shock in Mice by a Sugar Cane (Saccharum officinarumL.) Extract

Hikosaka

Koyama

Motobu

et al. 2006

Bioscience, Biotechnology, and Biochemistry

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Immunostimulating effects of sugar cane extract on X-ray radiation induced immunosuppression in the chicken

Cited by 26 publications

References 22 publications

Immunological and Therapeutic Evaluation of Wheat (Triticum aestivum) Derived Betaglucans against Coccidiosis in Chicken

Immunological and Therapeutic Evaluation of Wheat (Triticum aestivum) Derived Betaglucans against Coccidiosis in Chicken

Effects of Sugar Cane Extract on Pseudorabies Virus Challenge of Pigs

Reduced Lipopolysaccharide (LPS)-Induced Nitric Oxide Production in Peritoneal Macrophages and Inhibited LPS-Induced Lethal Shock in Mice by a Sugar Cane (Saccharum officinarumL.) Extract

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