Immunosuppressive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidens pilosa L.

Pereira, Rachel L.C; Ibrahim, Tereza; Lucchetti, Leonardo; Silva, Antônio Jorge R. da; Moraes, Vera Lúcia Gonçalves de

doi:10.1016/s0162-3109(99)00039-9

Cited by 95 publications

(77 citation statements)

References 12 publications

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“…5 Originally based in popular use by successive generations, traditional medicine has been a source of pharmacotherapy for millions of people worldwide. [6][7][8] Plants can provide a vast source of active natural products for the discovery of new drugs. Secondary metabolites from plants, such as terpenes, phenols, and alkaloids, are known to modulate the expression of proinflammatory signals and have shown potent biological activities, providing lead compounds in drug discovery for the treatment of many conditions and diseases, for instance, microbial infections, cancer, and inflammation.…”

Section: Introductionmentioning

confidence: 99%

α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice

D'Almeida¹,

Oliveira²,

Souza³

et al. 2017

IJN

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Acute respiratory distress syndrome (ARDS) is a severe clinical condition of respiratory failure due to an intense inflammatory response with different etiologies. Despite all efforts, therapy remains limited, and ARDS is still associated with high mortality and morbidity. Plants can provide a vast source of active natural products for the discovery of new drugs. α-bisabolol (α-bis), a constituent of the essential oil from chamomile, has elicited pharmacological interest. However, the molecule has some limitations to its biological application. This study was conducted to develop a drug delivery system using lipid-core nanocapsules (LNCs) to improve the anti-inflammatory effects of orally administered α-bis. α-bis-loaded LNCs (α-bis-LNCs) were prepared by interfacial deposition of poly(ε-caprolactone) and orally administered in a mouse model of ARDS triggered by an intranasal administration of lipopolysaccharide (LPS). We found that α-bis-LNCs (30, 50, and 100 mg kg −1 ) significantly reduced airway hyperreactivity (AHR), neutrophil infiltration, myeloperoxidase activity, chemokine levels (KC and MIP-2), and tissue lung injury 18 hours after the LPS challenge. By contrast, free α-bis failed to modify AHR and neutrophil accumulation in the bronchoalveolar lavage effluent and lung parenchyma and inhibited elevation in the myeloperoxidase and MIP-2 levels only at the highest dose. Furthermore, only α-bis-LNCs reduced LPS-induced changes in mitogen-activated protein kinase signaling, as observed by a significant reduction in phosphorylation levels of ERK1/2, JNK, and p38 proteins. Taken together, our results clearly show that by using LNCs, α-bis was able to decrease LPS-induced inflammation. These findings may be explained by the robust increase of α-bis concentration in the lung tissue that was achieved by the LNCs. Altogether, these results indicate that α-bis-LNCs should further be investigated as a potential alternative for the treatment of ARDS.

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Section: Introductionmentioning

confidence: 99%

α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice

D'Almeida¹,

Oliveira²,

Souza³

et al. 2017

IJN

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“…The percentage of usage of this plant in different herbal treatment is comparatively higher than other herbal plants. It is widely used as antimalarial, stomach disorders, hypertension and anti-inflammatory (Alvarez et al, 1999;Andrade-Neto et al, 2004;Dimo et al, 2002;Pereira et al, 1999). The therapeutic potential for the liver fibrosis of the plant was assessed through rat and mouse model of the liver injury.…”

Section: Bidens Pilosamentioning

confidence: 99%

Anti-fibrotic activity of medicinal plants

Akhtar

Ahmad

2017

Bangladesh J Pharmacol

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<p class="Abstract">The aim of this review is to report the medicinal plants which have anti- fibrotic effect characterized in different studies. They are summarized which include name of the plants, part used, liver fibrosis model, fraction of plant used and observations. The medicinal plants play an important role in treatment and prevention of liver fibrosis through different physiological mechanism. The effects of medicinal plant may delay the development of liver fibrosis and have potential to reverse or degrade the accumulation of extra cellular matrix. Four different databases are used and 18 plants are included which have the potential for reversal of liver fibrosis. There are also few more plants but they are not characterized well in literature.</p>

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“…5) Previously it was reported that some Chinese medicines and plants had antiinflammatory and antiallergic activities. [6][7][8][9] Moreover, some extracts and flavonoids and caffeic acid were founded to have antiinflammatory and antiallergic activities. [10][11][12][13] Therefore MMBP may have antiinflammatory and antiallergic activities.…”

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confidence: 99%

Antiinflammatory and Antiallergic Activity of Bidens pilosa L. var. radiata SCHERFF

Horiuchi

Seyama

2006

JOURNAL OF HEALTH SCIENCE

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The suspension and the boiling water extract of dried powder from the aerial parts of Bidens pilosa L. var. radiata SCHERFF (Tachiawayukisendangusa: MMBP) on the Japanese island of Miyako have antiinflammatory and antiallergic properties in experimental diseases. Oral administration of MMBP suspension in carboxy-methyl-cellulose sodium solution inhibited the production of IgE 10 days after immunization with DNP-ascaris in mice. The extract inhibited histamine release from rat peritoneal mast cells induced by compound 48/80 or antigen-antibody reaction. Oral administration of the suspension inhibited dye exudation in rat skin induced by passive cutaneous anaphylaxis. Oral administration of the suspension inhibited dye exudation in rat skin induced by chemical mediators (histamine, substance P, and serotonin). These findings suggest that MMBP may be clinically useful in the prevention of type I allergic disease.

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Immunosuppressive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidens pilosa L.

Cited by 95 publications

References 12 publications

α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice

α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice

Anti-fibrotic activity of medicinal plants

Antiinflammatory and Antiallergic Activity of Bidens pilosa L. var. radiata SCHERFF

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Immunosuppressive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidens pilosa L.

Cited by 95 publications

References 12 publications

&alpha;-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice

&alpha;-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice

Anti-fibrotic activity of medicinal plants

Antiinflammatory and Antiallergic Activity of Bidens pilosa L. var. radiata SCHERFF

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Product

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α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice

α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice