1997
DOI: 10.1016/s0300-483x(97)03621-4
|View full text |Cite
|
Sign up to set email alerts
|

Immunotexicological effects of benzene inhalation in male Sprague-Dawley rats

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

3
25
0
3

Year Published

2002
2002
2010
2010

Publication Types

Select...
4
3
1

Relationship

0
8

Authors

Journals

citations
Cited by 42 publications
(31 citation statements)
references
References 28 publications
3
25
0
3
Order By: Relevance
“…It has been used as an industrial solvent, and is frequently seen in environmental contamination. Benzene exposure has been linked to hematotoxicity, hematopoietic dysfunction (Robinson et al, 1997), bone marrow stem cell damage and pancytopenia (Wierda et al, 1981;Bogadi-Sare et al, 2000). Lymphocytes, specifically precursor lymphocytes, are the most susceptible targets for benzene and its metabolites, such as catechol, hydroquinone, 1,2,4-benzenetriol and benzoquinone.…”
Section: Benzenementioning
confidence: 99%
See 1 more Smart Citation
“…It has been used as an industrial solvent, and is frequently seen in environmental contamination. Benzene exposure has been linked to hematotoxicity, hematopoietic dysfunction (Robinson et al, 1997), bone marrow stem cell damage and pancytopenia (Wierda et al, 1981;Bogadi-Sare et al, 2000). Lymphocytes, specifically precursor lymphocytes, are the most susceptible targets for benzene and its metabolites, such as catechol, hydroquinone, 1,2,4-benzenetriol and benzoquinone.…”
Section: Benzenementioning
confidence: 99%
“…Rats exposed to inhaled benzene at 400 ppm for 4 weeks (6 hr/day, 5 days/week) showed spleen and thymus weight reduction and reduced spleen cell numbers in Kappa+ (B-) lymphocytes, CD4+/CD5+ (TH) cells, and CD5+ (pan-T) lymphocytes (Robinson et al, 1997). A human study found significant B lymphocyte depression in workers exposed to concentrations of 15 ppm or less benzene in solvents compared to a control population (Boagdi-Sare et al, 2000).…”
Section: Benzenementioning
confidence: 99%
“…Contudo, efeitos adversos à saúde associados com a produção e uso de HQ está descrito na literatura relacionado ao fato de ser metabólito do BZ (DE CAPRIO, 1999). BZ é um solvente industrial amplamente utilizado (intermediário da síntese de várias substâncias químicas), constituindo-se em poluente ambiental gerado pelo processo de combustão e evaporação da gasolina e componente da fumaça do 21 cigarro (FARRIS et al, 1997). A via respiratória é a principal fonte de exposição do BZ no homem.…”
Section: Hidroquinonaunclassified
“…A via respiratória é a principal fonte de exposição do BZ no homem. Exposição crônica por inalação está associada com alterações hematopoiéticas implicadas no desenvolvimento de pancitopenia, anemia aplástica e leucemia em humanos (ROBINSON et al, 1997; Tais produtos oxidados serão substratos para enzimas hepáticas de fase II…”
Section: Hidroquinonaunclassified
“…A administração de HQ in vivo promove neutrofilia (para revisão ver SNYDER, 2002SNYDER, , 2004, e reduz o número de células mononucleares no sangue periférico (GILL et al, 1980;SNYDER et al, 1980;GREEN et al, 1981;CRONKITE et al, 1984;FARRIS et al, 1997), na medula e em órgãos linfóides secundários (FARRIS et al, 1997;ROBINSON et al, 1997, VELASCO-LEZAMA et al, 2001. Além dos efeitos sob a produção e/ou maturação leucocitária, há evidências do papel da HQ sobre a atividade celular.…”
Section: Efeitos Tóxicos Da Hidroquinonaunclassified