Impact of a soy drink on climacteric symptoms: an open-label, crossover, randomized clinical trial

Tranche, Salvador; Brotons, Carlos; Pisa, Beatriz Pascual de la; Macı́as, Ramón; Hevia, Eduardo; Marzo-Castillejo, Mercè

doi:10.3109/09513590.2015.1132305

Cited by 24 publications

(31 citation statements)

References 44 publications

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“…This observation was not replicated in the high-dose group, possibly due to the sample size, and thus, further studies are required to confirm these findings. Our findings in the medium group are in agreement with an open-label crossover study that demonstrated a commercial soy drink (ViveSoy ® ), providing ~ 50 mg IFs per day for 12 weeks, improved climacteric symptoms including hot flushes in peri/post-menopausal women [69]. Previous research on the effects of soy foods on menopausal symptoms is limited [70] and our findings warrant further study in this area.…”

Section: Discussionsupporting

confidence: 88%

Consumption of a soy drink has no effect on cognitive function but may alleviate vasomotor symptoms in post-menopausal women; a randomised trial

et al. 2019

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Purpose Cognitive decline is commonly reported during the menopausal transition, with memory and attention being particularly affected. The aim of this study was to investigate the effects of a commercially available soy drink on cognitive function and menopausal symptoms in post-menopausal women. Methods 101 post-menopausal women, aged 44-63 years, were randomly assigned to consume a volume of soy drink providing a low (10 mg/day; control group), medium (35 mg/day), or high (60 mg/day) dose of isoflavones for 12 weeks. Cognitive function (spatial working memory, spatial span, pattern recognition memory, 5-choice reaction time, and match to sample visual search) was assessed using CANTAB pre-and post-the 12 week intervention. Menopausal symptoms were assessed using Greene's Climacteric Scale. Results No significant differences were observed between the groups for any of the cognitive function outcomes measured. Soy drink consumption had no effect on menopausal symptoms overall; however, when women were stratified according to the severity of vasomotor symptoms (VMS) at baseline, women with more severe symptoms at baseline in the medium group had a significant reduction (P = 0.001) in VMS post-intervention (mean change from baseline score: − 2.15 ± 1.73) in comparison to those with less severe VMS (mean change from baseline score: 0.06 ± 1.21). Conclusions Soy drink consumption had no effect on cognitive function in post-menopausal women. Consumption of ~ 350 ml/day (35 mg IFs) for 12 weeks significantly reduced VMS in those with more severe symptoms at baseline. This finding is clinically relevant as soy drinks may provide an alternative, natural, treatment for alleviating VMS, highly prevalent among western women.

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Section: Discussionsupporting

confidence: 88%

Consumption of a soy drink has no effect on cognitive function but may alleviate vasomotor symptoms in post-menopausal women; a randomised trial

et al. 2019

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“…The results indicated that under the influence of yoga, MRS symptoms in three domains (somato-vegetative, psychological and uro-genital) were significantly reduced, and, in addition, menopausal symptoms improved considerably according to the MENQOL (Vora, Dangi, 2014). The aim of a Spanish randomized, open and controlled study in 2012 conducted using the MRS among 147 women was to assess the effects of a soya drink, with increased content of isoflavones, on menopausal complaints of women (Tranche et al, 2016). An improvement in both somatic and urogenital symptoms, and an improvement in quality of life of women pre-and post-menopause (Tranche et al, 2016) were indicated.…”

Section: Studies Focusing On Using Alternative Methods Of Menopause Tmentioning

confidence: 99%

Use of evaluation tools to evaluate symptoms and changes in climacteric women in the Czech Republic and abroad

Belešová¹,

Tóthová²

2019

Cent Eur J Nurs Midw

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Aim: The paper surveys empirical research on the use of evaluation tools with the purpose of evaluating symptoms and changes in climacteric women in the Czech Republic and other countries. In order to evaluate the range of individual symptoms, a great number of standardized questionnaires and measuring scales have been created, which are logically designed for clear statistic evaluation, and are used on a global scale to measure the severity of disorders, or quality of life of women. Design: A literature review. Methods: In outline, the article is an overview making use of content analysis of studies published in scientific databases, e.g. EBSCO, PubMed, ProQuest, and ScienceDirect, during the years 2012 to 2018. The overview focuses on articles dealing with the use of evaluation tools in connection with menopause. After screening for eligibility, 25 articles were eventually analyzed. Results: Following analysis of the results of foreign empirical research, it was apparent that the most common evaluation tool for defining the types and level of symptoms in climacteric women was the Menopausal Rating Scale. Besides this tool, other tools, such as the Greene Climacteric Scale, the Kuperrman index, the Menopause-Specific Quality of Life Questionnaire, the Womenʼs Health Questionnaire, and the Utian Quality of life Scale were used in this field. Two studies focusing on the Czech Republic were analyzed. The standardized tool used in these cases was the Menopausal Rating Scale. Conclusion: A number of foreign studies have been conducted regarding climacteric women monitoring symptoms and changes in psychological condition and behaviour, and changes in their cognitive and emotional states, or evaluating their quality of life. However, only two such studies have been undertaken in the Czech Republic.

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“…En un reciente ensayo clínico abierto, aleatorizado, cruzado y controlado, llevado a cabo por Tranché et al (17) en 90 mujeres peri y postmenopáusicas, se evidenció que la bebida de soja, ingerida durante 12 semanas, tenía un efecto significativo sobre los síntomas climatéricos (20,4%), y se redujeron en un 21,3% los síntomas y problemas urogenitales, así mejoró un 18% la calidad de vida relacionada con la salud.…”

Section: Estudios Que Analizan El Efecto Del Consumo De Soja Sobre Launclassified

Beneficios de la soja en la salud femenina

Salinas

López-Sobaler

2017

Nutr Hosp

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Martín Salinas C, López-Sobaler AM. Beneficios de la soja en la salud femenina. Nutr Hosp 2017;34(Supl. AbstractA great interest has been developed last decades on the role of phytoestrogens as an alternative to hormone replacement therapy. In fact, numerous studies have shown the effects of soy isoflavones on climacteric symptomatology by significantly reducing the frequency and intensity of hot flashes, as well on cardiovascular health. The aim of this paper was to review the last studies, mainly randomized controlled trials, on the effect of isoflavones on climacteric symptoms and their impact on women's quality of life, as well as on other health markers. Following a review of meta-analyzes and recent clinical trials, evidence has been obtained of the efficacy of isoflavones use in reducing hot flashes, improving the quality of life, lowering the cardiovascular risk by optimizing lipid profile, and Improving bone mineral density and other markers of bone resorption. Most of the authors concluded on the favorable effect of regular consumption of soy isoflavones on the health and quality of life of peri and postmenopausal women.Beneficios de la soja en la salud femenina ResumenDesde hace varias décadas, se ha desarrollado un gran interés por el papel de los fitoestrógenos como alternativa a la terapia hormonal sustitutiva. De hecho, numerosos estudios han determinado los efectos de las isoflavonas de soja sobre la sintomatología climatérica al reducir significativamente la frecuencia e intensidad de los sofocos. Este resultado se ha observado también sobre la salud cardiovascular. El objetivo de este trabajo ha sido revisar los estudios publicados, principalmente ensayos clínicos aleatorizados y controlados sobre el efecto de las isoflavonas en los síntomas climatéricos y su repercusión en la calidad de vida de la mujer, así como en otros marcadores de salud. Tras una revisión de metaanálisis y ensayos clínicos recientes, se ha obtenido evidencia de la eficacia del consumo de isoflavonas en la reducción de los sofocos con una mejora de la calidad de vida, en la disminución del riesgo cardiovascular por optimización del perfil lipídico, y en la mejoría de la densidad mineral ósea y otros marcadores de resorción ósea. La mayoría de los autores concluyen en el efecto favorable de un consumo regular de isoflavonas de soja sobre la salud y la calidad de vida de la mujer peri y postmenopáusica.

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Impact of a soy drink on climacteric symptoms: an open-label, crossover, randomized clinical trial

Cited by 24 publications

References 44 publications

Consumption of a soy drink has no effect on cognitive function but may alleviate vasomotor symptoms in post-menopausal women; a randomised trial

Consumption of a soy drink has no effect on cognitive function but may alleviate vasomotor symptoms in post-menopausal women; a randomised trial

Use of evaluation tools to evaluate symptoms and changes in climacteric women in the Czech Republic and abroad

Beneficios de la soja en la salud femenina

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