Impact of adjusted kidney volume measured in the bench surgery on one-year renal function in kidney transplantation

Ordones, Flávio Vasconcelos; Pajolli, Pedro Ivo Rocchetti; Guerra, Rodrigo; Yamamoto, Hamilto Akihissa; Filho, Fernando Fereira Gomes; Kawano, Paulo Roberto; Amaro, João Luiz; Andrade, Luís Gustavo Modelli de

doi:10.1371/journal.pone.0224364

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…Likewise, previous studies found an association with donor’s kidney size at ultrasounds or kidney volume at the CT scan or at the time of surgery and recipient’s renal function [43‒47]. Our data do not support a close correlation between donor’s kidney size and recipient’s kidney function, possibly because of the use of a less sensitive technique [48].…”

Section: Discussioncontrasting

confidence: 94%

Outcomes in Living Donor Kidney Transplantation: The Role of Donor’s Kidney Function

Torreggiani

Esposito

Martinelli

et al. 2021

Kidney Blood Press Res

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Introduction: Living donor kidney transplant (LDKT) is one of the best therapeutic options for end-stage kidney disease (ESKD). Guidelines identify different estimated glomerular filtration rate (eGFR) thresholds to determine the eligibility of donors. The aim of our study was to evaluate whether pretransplant donor eGFR was associated with kidney function in the recipient. Methods: We retrospectively studied LDKT recipients who received a kidney graft between September 1, 2005, and June 30, 2016 in the same transplant center in France and that had eGFR data available at 3, 12, 24, and 36 months posttransplant. Results: We studied 90 donor-recipient pairs. The average age at time of transplant was 51.47 ± 10.95 for donors and 43.04 ± 13.52 years for recipients. Donors’ average eGFR was 91.99 ± 15.37 mL/min/1.73 m2. Donor’s age and eGFR were significantly correlated (p < 0.0001, r2 0.023). Donor’s age and eGFR significantly correlated with recipient’s eGFR at 3, 12, and 24 months posttransplant (age: p < 0.001 at all intervals; eGFR p = 0.001, 0.003, and 0.016, respectively); at 36 months, only donor’s age significantly correlated with recipient’s eGFR. BMI, gender match, and year of kidney transplant did not correlate with graft function. In the multivariable analyses, donor’s eGFR and donor’s age were found to be associated with graft function; correlation with eGFR was lost at 36 months; and donor’s age retained a strong correlation with graft function at all intervals (p < 0.001). Conclusions: Donor’s eGFR and age are strong predictors of recipient’s kidney function at 3 years. We suggest that donor’s eGFR should be clinically balanced with other determinants of kidney function and in particular with age.

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Section: Discussioncontrasting

confidence: 94%

Outcomes in Living Donor Kidney Transplantation: The Role of Donor’s Kidney Function

Torreggiani

Esposito

Martinelli

et al. 2021

Kidney Blood Press Res

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“…24 Higher overall kidney volume, assessed at the time of transplantation, predicted a higher eGFR at 1-y posttransplant. 30 Furthermore, patients with decreased overall graft size ascertained at 1 y, compared to 1 mo after transplantation were at significantly increased risk of subsequent graft dysfunction and end-stage graft failure. 31 Unfortunately, none of these studies correlated overall renal size with histopathologic markers of acute or chronic renal injury.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Glomerular Size With Donor–Recipient Factors and With Response to Injury

2021

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“…The percentile curves may also have some clinical implications in renal transplantation. Although today, one usually does not take into account kidney size to decide which kidney should be given to which patient, in general, larger donor kidneys result in better graft function at follow up [32]. The percentile curves in our article will allow clinicians to estimate expected kidney size of potential donors before organ removal or imaging.…”

Section: Discussionmentioning

confidence: 99%

Reference values and sex differences in absolute and relative kidney size. A Swiss autopsy study

Kalucki¹,

Lardi²,

Garessus³

et al. 2020

BMC Nephrol

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Background: Men have larger kidneys than women, but it is unclear whether gender remains an independent predictor of kidney size (expressed as weight or length) after correction for body size. We analysed autopsy data to assess whether relative renal length and weight (e.g. corrected for body weight, height or body surface area (BSA)) are also larger in men. Assuming that kidney size is associated with nephron number, opposite findings could partly explain why women are less prone to the development and progression of chronic kidney disease than men. Methods: All forensic autopsies performed between 2009 and 2015 at the local university hospital of Geneva in individuals of European descent aged ≥18 years without a known history of diabetes and/or kidney disease were examined. Individuals with putrefied or severely injured bodies were excluded. Relative renal weight and length were respectively defined as renal weight divided by body weight or BSA and renal length divided by body height or BSA. Results: A total of 635 autopsies (68.7% men) were included in the analysis. Left kidneys were on average 8 g heavier and 2 mm longer than right kidneys (both: p < 0.05). Absolute renal weight (165 ± 40 vs 122 ± 29 g) and length (12.0 ± 1.3 vs 11.4 ± 1.1 cm) were higher in men. Relative renal weight was also higher in men, but relative renal length was larger in women. In multivariable regression analysis, body height, body weight, the degree of blood congestion or depletion at autopsy and age were determinants of renal weight, whereas arterial hypertension and smoking were not. Percentile curves of renal weight and length according to sex and body height were constructed. Conclusion: Absolute and relative renal weights were both smaller in women. This is in line with recent studies stating that nephron numbers are also lower in women. Relative renal length was longer in women, suggesting that female kidneys have a more elongated shape. In comparison with older autopsy studies, renal weight appears to be stable over time.

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Impact of adjusted kidney volume measured in the bench surgery on one-year renal function in kidney transplantation

Cited by 4 publications

References 30 publications

Outcomes in Living Donor Kidney Transplantation: The Role of Donor’s Kidney Function

Outcomes in Living Donor Kidney Transplantation: The Role of Donor’s Kidney Function

Correlation of Glomerular Size With Donor–Recipient Factors and With Response to Injury

Reference values and sex differences in absolute and relative kidney size. A Swiss autopsy study

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