BackgroundKidney transplantation is the treatment of choice in patient with end stage chronic kidney disease, offering the best long term survival and greater Quality of Life in this group of patients. Graft volume was correlated with improved renal function in living donor transplantations. The primary aim of this study was to correlate renal volume adjusted to body surface area with renal function one year (estimated glomerular filtration rate; eGFR) after kidney transplantation.MethodsThis single-center, prospective cohort study included 256 patients who underwent kidney transplantation from January 2011 through December 2015 at Hospital das Clínicas de Botucatu–UNESP. We evaluated three kidney measurements during the bench surgery; the final graft volume was calculated using the ellipsoid formula and adjusted to body surface area.ResultsIn the living donors there was positive correlation between adjusted graft volume and eGFR (r = 0.311, p = 0.008). Multivariate analysis revealed that low rejection rate and increased adjusted graft volume were independent factors correlated with eGFR. In deceased donors, there was no correlation between adjusted kidney volume and eGFR (r = 0.08, p = 0.279) in univariate analysis, but a multivariate analysis indicated that lower kidney donor profile index (KDPI), absence of rejection and high adjusted kidney volume were independent factors for better eGFR.ConclusionAdjusted kidney volume was positively correlated with a satisfactory eGFR at one year after living donor and deceased donor transplantations.
Purpose:To evaluate the effects of tadalafil (TD) in preventing histological
alterations of the corpus cavernosum caused by isolated lesions of cavernous
nerve (ILCN) and artery (ILCA) in rats.Methods:Fifty male Wistar rats were randomly assigned in five groups: G1: control;
G2: bilateral ILCN; G3: bilateral ILCA; G4: ILCN+TD; G5: ILCA+TD. The
cavernous bodies were submitted to histomorphometry, immunohistochemistry
and biochemical analysis.Results:Nerve density was significantly higher in G2 and G4 compared to control
(22.62±2.84 and 19.53±3.47 vs. 15.72±1.82; respectively, p<0.05). Smooth
muscle density was significantly lower in G2 and G3 in comparison to G1
(12.87±1.90 and 18.93±1.51 vs. 21.78±1.81, respectively; p<0.05). A
significant decrease in the sinusoidal lumen area was observed in G2
compared to controls (5.01±1.62 vs. 9.88±3.66, respectively; p<0.05) and
the blood vessel density was increased in G2 and G3 (29.32±4.13 e 20.80±2.47
vs. 10.13±2.71, p<0.05). Collagen density was higher in G3 compared to G1
(93.76±15.81 vs. 64.59±19.25; p<0.05).Conclusions:Histomorphometric alterations caused by ILCN were more intense than those
produced by vascular injury, but the collagen analyses showed more fibrosis
in animals with ILCA. TD was effective in preventing the majority of the
alterations induced by the periprostatic bundle injury.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.