Impact of benign childhood epilepsy with centrotemporal spikes (BECTS) on school performance

Miziara, Carmen Silvia Molleis Galego; Manreza, Maria Luíza Giraldes de; Mansur, Letı́cia Lessa; Reed, Umbertina Conti; Guilhoto, Laura Maria de Figueiredo Ferreira; Serrano, Virginia Aparecida Gelmeti; Góis, Solange

doi:10.1016/j.seizure.2011.09.004

Cited by 40 publications

(46 citation statements)

References 33 publications

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“…reported that 31% had attention deficit–hyperactivity disorder, 21.9% had specific cognitive deficits, and 11.7% had behavioral abnormalities, including aggressiveness, anxiety disorders, depression, and pervasive developmental disorder. Children with BRE scored significantly lower in tests on academic performance, when compared with those in the control group . Consistent with this, on neuroimaging, BRE has an impact on structural and functional brain development .…”

Section: Discussionsupporting

confidence: 66%

Atypical features of benign rolandic epilepsy in Chinese children: Retrospective study

Wang

Zhang

et al. 2017

Pediatrics International

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Section: Discussionsupporting

confidence: 66%

Atypical features of benign rolandic epilepsy in Chinese children: Retrospective study

Wang

Zhang

et al. 2017

Pediatrics International

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“…The impact of interictal EEG focal spikes on cognition in children with epilepsy has been a source of debate for several decades [24, 25, 28–31]. EEG focal spikes temporally and regionally correlate with transient cognitive impairment [21], and are associated in RE probands with attentional impairment [32] and might disrupt overnight memory consolidation [27].…”

Section: Discussionmentioning

confidence: 99%

Risk factors for reading disability in families with rolandic epilepsy

Vega

Smith

Cockerill

et al. 2015

Epilepsy & Behavior

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OBJECTIVE The high prevalence and impact of neurodevelopmental comorbidities in childhood epilepsy are now well known, as are the increased risks and familial aggregation of reading disability (RD) and speech sound disorder (SSD) in rolandic epilepsy (RE). The risk factors for RD in the general population include male sex, SSD and ADHD but it is not known if these are the same in RE or whether there is a contributory role of seizure and treatment related variables. METHODS An observational study of 108 RE probands (age range 3.6–22 years) and their 159 siblings (age range 1–29 years; 83 with EEG data) singly ascertained in the US or UK through an affected RE proband. We used a nested case-control design, multiple logistic regression and generalized estimating equations to test the hypothesis of association between RD and seizure variables or antiepileptic drug treatment in RE; we also assessed an association between EEG focal sharp waves and RD in siblings. RESULTS RD was reported in 42% of probands and 22% of siblings. Among probands, RD was strongly associated with a history of SSD (OR 9.64, 95% CI: 2.45–37.21), ADHD symptoms (OR 10.31, 95% CI: 2.15–49.44), and male sex (OR 3.62, 95% CI: 1.11–11.75), but not with seizure or treatment variables. Among siblings, RD was independently associated only with SSD (OR 4.30, 95%CI: 1.42–13.0) and not with the presence of interictal EEG focal sharp waves. SIGNIFICANCE The principal risk factors for RD in RE are SSD, ADHD and male sex, the same risk factors as for RD without epilepsy. Seizure or treatment variables do not appear to be important risk factors for RD in RE probands, and there was no evidence to support interictal EEG focal sharp waves as a risk factor for RD in siblings. Future studies should focus on the precise neuropsychological characterisation of RD in RE families, and on the effectiveness of standard oral-language and reading interventions.

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“…Significant correlations between spike frequency and cognition have also been found during drowsiness, but these did not survive correction for multiple testing. Other studies have found no significant associations between cognition and spike activity . The heterogeneity of these findings might be explained by the fact that intra‐subject variability in discharges is known to be very high and would need to be measured contemporaneously with cognitive testing to clarify associations .…”

mentioning

confidence: 92%

“…Other studies have found no significant associations between cognition and spike activity. [9][10][11][12][13] The heterogeneity of these findings might be explained by the fact that intra-subject variability in discharges is known to be very high and would need to be measured contemporaneously with cognitive testing to clarify associations. 14 The observation that a proportion of children have speech and language therapy before they are diagnosed with rolandic epilepsy 15 suggests that the language difficulties may well precede spikes and/ or seizures, ruling out causality, but, of course, onset of seizures is difficult to ascertain given that they are often nocturnal and can go unnoticed.…”

mentioning

confidence: 99%

A meta‐analysis of literacy and language in children with rolandic epilepsy

Smith

Bajomo

Pal

2015

Develop Med Child Neuro

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BECTSBenign childhood epilepsy with centrotemporal spikes AIM Rolandic epilepsy is the most common childhood epilepsy, often presenting with neuropsychological impairments. The aim of the study was to formally assimilate the findings of existing studies varying widely in methodology, thereby confirming the nature and prevalence of impairments in literacy and language.METHODS Using meta-analytical techniques, we evaluated 22 studies of literacy and/or language skills in children with rolandic epilepsy, published after 2000, among participants with IQs>70 and in which effect sizes could be acquired. Diagnosis required the presence of classical centrotemporal spikes arising from a normal background on electroencephalograms; a clinical history including at least one seizure; and no additional neurological condition.Overall effect size and heterogeneity were measured for single-word reading, phonological processing, and expressive and receptive language.RESULTS Mean effect sizes (Cohen's d) ranged from 0.50 (95% confidence interval [CI] 0.23-0.78) for phonological processing, through 0.71 (95% CI 0.52-0.90) for word reading and 0.72 (95% CI 0.34-1.1) for receptive language, to 0.75 (95% CI 0.45-1.05) for expressive language. While group differences for reading measures were consistent, those for language were heterogeneous and varied across studies explained by age and IQ of samples.

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Impact of benign childhood epilepsy with centrotemporal spikes (BECTS) on school performance

Abstract: Children with BECTS scored significantly lower scores in tests on academic performance, when compared with those in the control group probably due to executive dysfunction.

Cited by 40 publications

References 33 publications

Atypical features of benign rolandic epilepsy in Chinese children: Retrospective study

Atypical features of benign rolandic epilepsy in Chinese children: Retrospective study

Risk factors for reading disability in families with rolandic epilepsy

A meta‐analysis of literacy and language in children with rolandic epilepsy

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