Impact of Body Mass Index on Left Ventricular Diastolic Dysfunction

Çil, Habib; Bulur, Serkan; Türker, Yasin; Kaya, Ahmet; Alemdar, Recai; Karabacak, Ahmet; Aslantaş, Yusuf; Ekinözü, İ̇smail; Albayrak, Sinan; Özhan, Hakan

doi:10.1111/j.1540-8175.2012.01688.x

Cited by 42 publications

(28 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, in adult subjects, a link has been shown between obesity itself and subclinical cardiac structural changes leading to an "obese cardiomyopathy" syndrome [1]. Several authors have reported associations of obesity with increased left ventricular (LV) wall stress and compensatory LV hypertrophy [2], LV dilation, and even heart failure [3].…”

Section: Introductionmentioning

confidence: 99%

Left ventricular diastolic function and cardiometabolic factors in obese normotensive children

Porcar-Almela

Codoñer‐Franch

Tuzón

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Left ventricular diastolic function and cardiometabolic factors in obese normotensive children

Porcar-Almela

Codoñer‐Franch

Tuzón

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

“…It is one of the most important health problems in the world and is associated with a large spectrum of cardiovascular changes resulting from altered hemodynamics and inflammation (1, 2). Among these changes, left atrial (LA) enlargement and subclinical impairment of left ventricular (LV) function are precursors to more serious forms of cardiac dysfunction and heart failure (3).…”

Section: Introductionmentioning

confidence: 99%

Mitral annular plane systolic excursion in the assessment of left ventricular diastolic dysfunction in obese adults

Taşolar

Mete

Çetın³

et al. 2015

Anatol J Cardiol

View full text Add to dashboard Cite

Objective:Mitral annular plane systolic excursion (MAPSE) is a simple way to assess left ventricle (LV) function. MAPSE is also correlated to parameters, illustrating the close relation between systolic and diastolic function of LV. In this study, we evaluated whether MAPSE could help us in the determination the LV diastolic dysfunction (DD) in obese adults.Methods:Our study was a prospective cross-sectional study. Obese patients who were referred from the endocrinology clinic were enrolled into this study. The participants included 40 obese patients with early-stage DD (grade I and II) and 40 obese patients with normal diastolic function, with an equal number of males and females. The patients with DD were further divided into Obese DD+I, who had grade I DD, and Obese DD+II, who had grade II DD. Student t-test, Mann-Whitney U test, one-way analysis of variance, ROC curve analysis, and pairwise comparisons of the ROC curves were used for statistical analysis.Results:MAPSE was different in all groups, with the lowest value in the Obese DD+II group (p<0.001). E/Em ratio was also different among all groups and was highest in the Obese DD+II group (p<0.001). Furthermore, MAPSE was negatively correlated with E/Em ratio (r=-0.368, p=0.020). The optimal threshold point of MAPSE in the diagnosis of left ventricle diastolic dysfunction (LVDD) was ≥1.45 cm, with 92.5% sensitivity (95% CI 79.6-98.4) and 77.5% specificity (95% CI 61.5-89.2) in the ROC curve analysis. There was no difference in the pairwise comparisons of the ROC curves of MAPSE and E/Em ratio in the diagnosis of DD [area under the ROC curve 0.902 (0.033) vs. 0.927 (0.027); p=0.54].Conclusion:Consequently, we found significantly a close relationship between MAPSE with conventional echocardiographic parameters, especially with E/Em, in the detection of left ventricle diastolic dysfunction (LVDD) in obese adults with normal LV ejection fraction. We think that MAPSE is a simple, easily acquired and less time consuming measurement and may help us in the stratification of LVDD in obese adults.

show abstract

“…Increased BMI is a risk factor for hypertension, diabetes and dyslipidemia, all of which augment the risk of ischemic heart disease, and hypertension and diabetes independently increase the risk of heart failure [5]. In addition, elevated BMI is associated with increased left ventricular (LV) mass [5,6], and altered LV remodeling [6]; however, the association of BMI with diastolic dysfunction is independent of age, hypertension, diabetes and LV mass [1,2]. Other mechanisms by which BMI may impact on diastolic function and risk of heart failure include altered myocardial structure, neurohormonal activation and altered myocardial metabolism [4,7-9].…”

Section: Introductionmentioning

confidence: 99%

Obesity Is Associated with Lower Coronary Microvascular Density

et al. 2013

View full text Add to dashboard Cite

BackgroundObesity is associated with diastolic dysfunction, lower maximal myocardial blood flow, impaired myocardial metabolism and increased risk of heart failure. We examined the association between obesity, left ventricular filling pressure and myocardial structure.MethodsWe performed histological analysis of non-ischemic myocardium from 57 patients (46 men and 11 women) undergoing coronary artery bypass graft surgery who did not have previous cardiac surgery, myocardial infarction, heart failure, atrial fibrillation or loop diuretic therapy.ResultsNon-obese (body mass index, BMI, ≤30 kg/m2, n=33) and obese patients (BMI >30 kg/m2, n=24) did not differ with respect to myocardial total, interstitial or perivascular fibrosis, arteriolar dimensions, or cardiomyocyte width. Obese patients had lower capillary length density (1145±239, mean±SD, vs. 1371±333 mm/mm3, P=0.007) and higher diffusion radius (16.9±1.5 vs. 15.6±2.0 μm, P=0.012), in comparison with non-obese patients. However, the diffusion radius/cardiomyocyte width ratio of obese patients (0.73±0.11 μm/μm) was not significantly different from that of non-obese patients (0.71±0.11 μm/μm), suggesting that differences in cardiomyocyte width explained in part the differences in capillary length density and diffusion radius between non-obese and obese patients. Increased BMI was associated with increased pulmonary capillary wedge pressure (PCWP, P<0.0001), and lower capillary length density was associated with both increased BMI (P=0.043) and increased PCWP (P=0.016).ConclusionsObesity and its accompanying increase in left ventricular filling pressure were associated with lower coronary microvascular density, which may contribute to the lower maximal myocardial blood flow, impaired myocardial metabolism, diastolic dysfunction and higher risk of heart failure in obese individuals.

show abstract

Impact of Body Mass Index on Left Ventricular Diastolic Dysfunction

Abstract: BMI is an independent predictor of LV diastolic dysfunction along with age, hypertension, and diabetes mellitus.

Cited by 42 publications

References 29 publications

Left ventricular diastolic function and cardiometabolic factors in obese normotensive children

Left ventricular diastolic function and cardiometabolic factors in obese normotensive children

Mitral annular plane systolic excursion in the assessment of left ventricular diastolic dysfunction in obese adults

Obesity Is Associated with Lower Coronary Microvascular Density

Contact Info

Product

Resources

About