Impact of clinical data on chest radiography sensitivity in detecting pulmonary abnormalities in immunocompromised patients with suspected pneumonia

Abstract

The sensitivity of CXR is too low to consider it a stand-alone technique for the evaluation of immunocompromised patients after HSCT with suspected pneumonia, even if the radiologist knows detailed clinical data. For these patients, an early chest CT evaluation is therefore recommended.

Gut Microbiota Predict Pulmonary Infiltrates after Allogeneic Hematopoietic Cell Transplantation

“…Computed tomography (CT) is often preferred because of the low sensitivity of chest X-rays in this population (6,7). Although nonspecific, abnormal parenchymal patterns such as airspace consolidation, ground glass opacities, nodules, and reticular changes (8) may help inform the differential diagnosis and guide the next step in clinical decision-making (9).…”

Prospective evaluation of drug-induced lung toxicity with high-resolution CT and transbronchial biopsy

“…Symptoms are often nonspecific and include rapidly developing dyspnoea and a dry, unproductive cough [3,5]. The radiography and CT appearance of the various forms of DR-ILD have been variously described in the literature [7,8]. CT enables precise assessment of the presence, pattern and distribution of parenchymal and airway abnormalities and has higher sensitivity compared with chest radiography, which may be normal in the early stages of DR-ILD [8].…”

“…The radiography and CT appearance of the various forms of DR-ILD have been variously described in the literature [7,8]. CT enables precise assessment of the presence, pattern and distribution of parenchymal and airway abnormalities and has higher sensitivity compared with chest radiography, which may be normal in the early stages of DR-ILD [8]. The radiological manifestations of DR-ILD correspond to the underlying histological findings: nonspecific interstitial pneumonia (NSIP), usual interstitial pneumonia (UIP), hypersensitivity pneumonia (HP), pulmonary oedema, (n=13); organizing pneumonia (OP) (n=9); hypersensitivity pneumonitis (HP) (n=2); alveolar haemorrage (AH) (n=2); non specific interstitial pneumonia (NSIP) (n=5); lipoid pneumonia (LP) (n=1); sarcoid-like pattern (n=1).…”

“…I sintomi sono spesso non specifici, includendo una dispnea rapidamente progressiva e tosse secca [3,5]. L'aspetto radiografico e TC delle varie tossicità da farmaci è stata variamente descritta in letteratura [7,8]. La TC offre una precisa valutazione della presenza, pattern e distribuzione delle alterazioni parenchimali e delle vie aeree, con una sensibilità maggiore rispetto alla radiografia, potendo infatti, quest'ultima, essere normale negli stadi iniziali di DR-ILD [8].…”

“…L'aspetto radiografico e TC delle varie tossicità da farmaci è stata variamente descritta in letteratura [7,8]. La TC offre una precisa valutazione della presenza, pattern e distribuzione delle alterazioni parenchimali e delle vie aeree, con una sensibilità maggiore rispetto alla radiografia, potendo infatti, quest'ultima, essere normale negli stadi iniziali di DR-ILD [8]. La manifestazione radiologica di una tossicità polmonare da farmaci può avere diversi corrispettivi istologici: polmonite interstiziale non specifica (NSIP), usual interstitial pneumonia (UIP), polmonite da ipersensibilità organising pneumonia (OP) and alveolar haemorrhage (AH).…”