Impact of common environmental chemicals bisphenol A and bisphenol S on the physiology of Lumbriculus variegatus

Vought, Victoria; Wang, Hongsheng

doi:10.1016/j.etap.2018.05.003

Cited by 26 publications

(10 citation statements)

References 46 publications

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“…variegatus has been extensively characterized as indicator organisms for toxic compounds in aquatic systems and proposed as a standard organism for sediment bioaccumulation tests. [14][15][16][17][18][19]27 Herein, we demonstrated that L. variegatus has application as an effective model for the teaching of the effects of pharmacological agents on an intact system. Using two novel assays, we describe three different behavioral endpoints, body reversal, helical swimming, and free locomotion, that can be measured without the need for costly or specialized equipment, regulatory approval, or highly specialized animal housing facilitiesrequirements that often prevent the teaching of in vivo practical skills.…”

Section: Discussionmentioning

confidence: 88%

“…variegatus is an aquatic worm inhabiting shallow freshwater ponds, lakes, and marshes, 13 and these animals have been extensively characterized as indicator organisms for toxic compounds in aquatic systems. [14][15][16][17][18][19] Touching the anterior of L. variegatus results in retraction and the reversal of body position, whereas touching the tail elicits helical swimming. 13 These behaviors have previously been described and used to determine the effects of exogenous compounds on L. variegatus.…”

mentioning

confidence: 99%

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Lumbriculus variegatus: A novel organism for in vivo pharmacology education

Seeley

Bellamy

Davies

et al. 2021

Pharmacology Res & Perspec

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Pharmacology is the study of how medicines and other drugs work and are processed by the body. 1 As such, pharmacology undergraduates require a comprehensive understanding of both in vitro and in vivo drug responses. Despite advances in molecular biologic techniques, studies in isolated cells and tissues do not fully model the complex interactions observed in whole organisms. Currently, in vivo validation remains critical in the drug discovery and development process. 2 In order to limit the use of animal models at this preclinic stage, the principles of replacement, reduction, and refinement, the 3Rs, 3 aims to address the potential harms to animals while supporting high-quality science and translation by addressing the benefits of this research. 4 Animal use in pharmacology education has steadily declined in the last 30 years, with their use in education and training accounting for <1% of in vivo experimental procedures in 2019 5 and <2% of students taught in vivo skills during their degree. 6

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Section: Discussionmentioning

confidence: 88%

mentioning

confidence: 99%

Lumbriculus variegatus: A novel organism for in vivo pharmacology education

Seeley

Bellamy

Davies

et al. 2021

Pharmacology Res & Perspec

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“…Lee, et al [44] found adverse effects on reproduction in the midge C. riparius as well as increased DNA damage at 1 mg/L BPA. The aquatic oligochaete Lumbriculus variegatus responded to chronic exposures to BPA or BPS with retarded regeneration ability after fragmentation and increased blood vessel pulse rates at > 10 -6 M [45].…”

Section: Acute Testsmentioning

confidence: 99%

Plastic Additive Bisphenol A: Toxicity in Surface- and Groundwater Crustaceans

Gerhardt¹

2019

J Toxicol Risk Assess

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Bisphenol A (BPA) is being considered by the European Union as a substance of very high concern, occurring worldwide due to its wide application in many plastic products, building materials, coatings and epoxy resins. The toxicity of BPA in groundwater invertebrates is insufficiently understood. Both acute (24 h) and chronic (28 d) toxicity was compared in Daphnia magna and ecologically important crustaceans in surface water (Gammarus fossarum, Eucyclops serrulatus) and groundwater (Niphargopsis casparyi, Proasellus slavus). Survival and spontaneous locomotory activity was recorded in real-time in the Multispecies Freshwater Biomonitor (MFB) and the new Microimpedance Sensor System (MSS) for Meiofauna. The benthic copepod E. serrulatus was the most sensitive test species, followed by the groundwater species N. casparyi and P. slavus with G. fossarum and D. magna being the least sensitive species in acute tests. In chronic exposures the most sensitive species was P. slavus, whereas the amphipods and D. magna showed overall similar sensitivity. G. fossarum showed slightly more sensitive behavioral responses compared to N. casparyi, while D. manga behavior was affected by an age-dependent increase, masking potential negative effects of BPA on locomotory activity. Feeding activity of G. fossarum was more sensitive than molting and reproduction of D. magna. G. fossarum can be recommended for toxicity evaluation of groundwater habitats, as no standard test procedures and toxicity data for groundwater species are available. The organisms might also be used as biomonitors for landfill leachates, wastewater treatment plants, sewage plants and paper recycling plants.

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“…Oligochaeta is a group of macroinvertebrates distributed in freshwater systems that has gained prominence in water quality studies (Martin et al, 2008). These organisms have been used as bioindicators (Rodriguez and Reynoldson, 2011) and test organisms in ecotoxicology research (Vought and Wang, 2018;Leppänen and Kukkonen, 1998). Thus, knowing aspects of its ecology and geographical distribution becomes very important for the data production to be used as a basis for bioassessment research and for public health issues, since Lumbriculus variegatus (Müller, 1774) (Lumbriculidae, Clitellata) was identified in as the intermediate host of Dioctophyme renale (Goeze, 1782) (Nematoda, Dioctophymatidae) (Mace and Anderson, 1975).…”

mentioning

confidence: 99%

Lumbriculus variegatus (Müller, 1774) (Oligochaeta, Lumbriculidae) in Campos do Jordão State Park, São Paulo, Brazil

et al. 2023

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The aim of this paper was recording the occurrence of the species Lumbriculus variegatus (Müller, 1774) (Oligochaeta, Lumbriculidae) in lotic systems of the State of São Paulo. Specimens were collected in Sapucaí River, located in Campos do Jordão State Park. The mapping of geographical distribution of this species is of interest to public health since L. variegatus may be an intermediate host of Dioctophyme renale (Goeze, 1782) (Nematoda, Dioctophymatidae), a parasite of recognized zoonotic potential. Distribution data serves as a basis for environmental monitoring and evaluation, being essential to map possible cases of the disease (Dioctophimosis) and provide information to health professionals.

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Impact of common environmental chemicals bisphenol A and bisphenol S on the physiology of Lumbriculus variegatus

Cited by 26 publications

References 46 publications

Lumbriculus variegatus: A novel organism for in vivo pharmacology education

Lumbriculus variegatus: A novel organism for in vivo pharmacology education

Plastic Additive Bisphenol A: Toxicity in Surface- and Groundwater Crustaceans

Lumbriculus variegatus (Müller, 1774) (Oligochaeta, Lumbriculidae) in Campos do Jordão State Park, São Paulo, Brazil

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