Impact of Escherichia coli infection in broiler breeder chicks: The effect of oxidative stress on weight gain

Rosa, Gilnéia da; Alba, Davi Fernando; Silva, Aniélen D.; Gris, Anderson; Mendes, Ricardo E.; Mostardeiro, Vitor Bastianello; Lopes, Thalison F.; Schetinger, Maria Rosa Chitolina; Stefani, Lenita M.; Lopes, Marcos T.; Boiago, Marcel Manente; Silva, Aleksandro S. Da

doi:10.1016/j.micpath.2019.103861

Cited by 15 publications

(15 citation statements)

References 29 publications

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“…Cytokines such as IL-1β, IL-6, and TNF-α have been implicated as mediators to induce fever, and subsequently increase basal metabolite rate and decrease growth performance. Thus, inhibition of cytokines was generally thought as a strategy to attenuate fever and stress (27,33). In the current study, reduction of maximum body temperature and the duration of fever were associated with decreased production of cytokines in Rg3-treated groups, which is consistent with previous reports.…”

Section: Discussionsupporting

confidence: 92%

“…Young broilers are more susceptible to pathogens than adults because of their immature immune system and high demand for nutrients (25)(26)(27). Thus, nutritional interventions were commonly used to maintain growth performance and alleviate the harmful consequences of bacterial LPS challenge (13,28,29).…”

Section: Discussionmentioning

confidence: 99%

“…Increased inflammatory cytokines alter metabolic process in cells, depleting nutrition of the immune system, and inhibiting the growth and development of animals (9,10). Therefore, regulation of pro-inflammatory cytokines and inflammatory mediators is wanted to prevent LPS-induced stress (27,33). In this study, Rg3 inhibited the production of IL-6, TNF-α, NO, and iNOS in a bird model, which gives us an enlightenment to use Rg3 and other ginsenosides to control inflammation-related diseases in the poultry industry.…”

Section: Discussionmentioning

confidence: 99%

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Ginsenoside Rg3 Ameliorates Stress of Broiler Chicks Induced by Escherichia coli Lipopolysaccharide

Shao

et al. 2022

Front. Vet. Sci.

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In broiler chicks, Escherichia coli lipopolysaccharide is a prominent cause for inflammatory damage and loss of immune homeostasis in broiler chicks. Ginsenosides have been shown to have anti-inflammatory and antioxidant effects. However, it has not been demonstrated that ginsenosides protect broiler chicks against stress induced by Escherichia coli lipopolysaccharide challenge. The aim of this is to investigate the protective effect of ginsenosides Rg1, Re, and Rg3 on Escherichia coli lipopolysaccharide-induced stress. Our results showed that Rg3 ameliorated growth inhibition and fever, as well as decreased the production of stress-related hormones in broilers with stress. The protective effect of Rg3 on the stressed chicks may be largely mediated by regulating inflammatory response and oxidative damage. Moreover, real-time quantitative-polymerase chain reaction (RT-qPCR) results demonstrated that Rg3 upregulated mRNA expression of mTOR, HO-1, and SOD-1. These results suggested that ginsenoside Rg3 and ginsenoside products contains Rg3 deserve further study for the control of immunological stress and inflammation in broiler chicks.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Ginsenoside Rg3 Ameliorates Stress of Broiler Chicks Induced by Escherichia coli Lipopolysaccharide

Shao

et al. 2022

Front. Vet. Sci.

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“…This negative effect could be in part mediated by the fact that E. coli induced excess production of ROS/RNS, exceeding the ability of the antioxidant defense system to cope with, which directly increase cell damage and subsequently reduce production [ 48 ]. da Rosa et al [ 49 ] reported that the negative effect of E. coli infection on chicken growth performance was mediated by oxidative stress indicated with remarkable elevation in serum and hepatic ROS formation. On the other hand, propolis supplementation was reported to improve egg production quantitatively and qualitatively in laying Japanese quail subjected to heat induced oxidative stress [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Modulating Laying Hens Productivity and Immune Performance in Response to Oxidative Stress Induced by E. coli Challenge Using Dietary Propolis Supplementation

et al. 2020

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Propolis (PR) is a resin product of bee colonies that has rich bioactive antioxidant and bactericidal compounds. Endotoxin, a byproduct of bacterial growth, is reported to cause progressive induction of endogenous oxidative stress and has negative impacts on individual health and wellbeing. Hereby, we investigated the ability of PR to alleviate the oxidative stress and immunosuppression imposed by avian pathogenic Escherichia coli using laying hen as a based model. In this study, PR was dietary supplemented to hens for 4 weeks at a concentration of 0.1%. At the beginning of the 4th week of the experiment, hens from control and PR treatment were injected with E. coli (O157:H7; 107 colonies/hen) or saline. The results showed significant (p < 0.05) negative impact of E. coli challenge on antioxidant status, immune response and productive performance. PR supplementation reduced (p < 0.05) inflammation markers levels (tumor necrosis factor α (TNFα) and interleukin 1β (IL-1β)) and plasma corticosterone concentration. The antioxidant status was ameliorated with dietary PR supplementation to challenged hens, showing significant (p < 0.05) reduction in malondialdehyde (MDA) levels and increasing total antioxidant capacity (TAC) concentrations. Cell mediated, as well as, humeral immune response improved significantly (p < 0.05) with dietary PR verified by the enhancement of T- and B-lymphocyte proliferation and the positive respond to phytohemagglutinin (PHA). Leucocyte cells viability increased significantly and the apoptotic factor forkhead box O3 (Foxo3) was reduced with PR supplementation. The current study revealed that dietary PR supplementation can effectively be used as an organic feed additive to overcome the endogenous oxidative stress induced by endotoxins challenge.

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“….The impact of colibacillosis on laying hens of the Hy-Line lineage (at 32 weeks old) characterized by approximately 40% laying, per day and large number of birds affected with diarrhea and then apathy followed by death [26]. Pathogenic strains are commonly of the O1, O2 and O78 serotypes.…”

Section: Effect Of Escherichia Coli Infection On Egg Production and Mortalitymentioning

confidence: 99%

Effect of cold fog disinfection on Escherichia coli affecting commercial egg layer flocks

Kaoud¹,

Mm²,

Abdelhamed³

2022

GSC Adv. Res. Rev.

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On a field level among poultry flocks a study was conducted to estimate the efficacy of the most common disinfectants against E. coli (APEC isolates) was determined. The selected disinfectants were; Formalin, Phenol, QAC, Halamid, Virkon" S and Micro Sept M against E. coli isolates of commercial egg- layer flocks in Egyptian farms. The recovered results showed that: (1) the incidence of E. coli in the observed commercial egg-layer flocks; the isolation of E. coli (APEC of rfbO157 gene ) from 4 commercial egg-layer flocks (26.7 %) out of 15 flocks, the mortalities rates at the end of 78 weeks of age was 20% and also, the current egg-production, average egg weight, hen housed day, hen housed egg and percent peak of egg-production were: 69.2%,58.3 gm, 70%,326,78% and 69%,respectivel. (2) Formalin, Micro Sept M and Virkon'S treatment demonstrated a significant reduction in E. coli populations especially by cold fogging method.

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Impact of Escherichia coli infection in broiler breeder chicks: The effect of oxidative stress on weight gain

Cited by 15 publications

References 29 publications

Ginsenoside Rg3 Ameliorates Stress of Broiler Chicks Induced by Escherichia coli Lipopolysaccharide

Ginsenoside Rg3 Ameliorates Stress of Broiler Chicks Induced by Escherichia coli Lipopolysaccharide

Modulating Laying Hens Productivity and Immune Performance in Response to Oxidative Stress Induced by E. coli Challenge Using Dietary Propolis Supplementation

Effect of cold fog disinfection on Escherichia coli affecting commercial egg layer flocks

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