Impact of estrogen therapy on temporomandibular joints of rats: Histological and hormone analytical study

Abdrabuh, Abrar; Baljon, Kamilya Jamel; Alyami, Yagoub

doi:10.1016/j.sdentj.2020.07.006

Cited by 10 publications

(8 citation statements)

References 20 publications

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“…Hormonal changes including an estrogen deficiency leads to an imbalance between bone resorption and formation and the bone loss process is initiated ( Ji and Yu, 2015 ). Estrogen therapy only slightly improves the condition ( Abdrabuh et al, 2020 ). Approximately 5%–6% bone loss occurs per year in postmenopausal women 5 years after menopause onset ( Bono and Einhorn, 2003 ).…”

Section: Discussionmentioning

confidence: 99%

Analysis of mandible trabecular structure using digital periapical radiographs to assess low bone quality in postmenopausal women

Diba

Gracea

Shantiningsih

et al. 2021

The Saudi Dental Journal

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Purpose To analyze the quality of mandibular trabecular structure in postmenopausal women using periapical radiographs. Postmenopausal women are subjected to low bone quality; hence, early detection methods are needed. In addition to bone mineral density (BMD), trabecular architecture must be assessed to determine bone quality. The mandible represents bone quality and allows the assessment of trabecular structure from periapical radiographs. Material and Methods Lumbar (BMDL) and femoral BMD (BMDF) examinations were performed using dual-energy X-ray absorptiometry (DXA) in 31 postmenopausal women and divided into normal, osteopenia, and osteoporotic groups. Periapical radiographs were taken at both posterior sites of the mandible. The region of interest was taken 2 mm from the apical root of the first molar. Trabecular parameters consisting of trabecular thickness (Tb.Th) and bone percentage (BA/TA) were measured using BoneJ. Results Both trabecular parameters were significantly correlated with BMDF [BA/TA (r = 0.3796; p < 0.05) and Tb.Th (r = 0.508; p < 0.05)]. BA/TA and Tb.Th were significantly different between the osteoporosis and normal groups (p < 0.05) contrast to osteopenia and normal groups (p > 0.05). Conclusion Changes in mandibular trabeculae structure in postmenopausal women can be assessed using periapical radiographs.

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Section: Discussionmentioning

confidence: 99%

Analysis of mandible trabecular structure using digital periapical radiographs to assess low bone quality in postmenopausal women

Diba

Gracea

Shantiningsih

et al. 2021

The Saudi Dental Journal

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“…For example, OVX resulted in increased thickness of articular soft tissues and decreased bone volume in rats with temporomandibular joint OA. 98 In other OVX studies involving the temporomandibular joint, E2/progesterone treatment has been shown to improve the articular disc and condylar cartilaginous layers, 99 reduce joint inflammation, 100 and alleviate joint nociception. 101 …”

Section: The Role Of Estrogen In Lbp and Oa Painmentioning

confidence: 98%

Low back pain and osteoarthritis pain: a perspective of estrogen

et al. 2023

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Low back pain (LBP) is the world’s leading cause of disability and is increasing in prevalence more rapidly than any other pain condition. Intervertebral disc (IVD) degeneration and facet joint osteoarthritis (FJOA) are two common causes of LBP, and both occur more frequently in elderly women than in other populations. Moreover, osteoarthritis (OA) and OA pain, regardless of the joint, are experienced by up to twice as many women as men, and this difference is amplified during menopause. Changes in estrogen may be an important contributor to these pain states. Receptors for estrogen have been found within IVD tissue and nearby joints, highlighting the potential roles of estrogen within and surrounding the IVDs and joints. In addition, estrogen supplementation has been shown to be effective at ameliorating IVD degeneration and OA progression, indicating its potential use as a therapeutic agent for people with LBP and OA pain. This review comprehensively examines the relationship between estrogen and these pain conditions by summarizing recent preclinical and clinical findings. The potential molecular mechanisms by which estrogen may relieve LBP associated with IVD degeneration and FJOA and OA pain are discussed.

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“…O rato é um modelo animal de pequeno porte e baixo custo, o que permite seu emprego em experimentos com longos períodos de observação (Mazuqueli Pereira et al, 2021). Anatomicamente, a ATM humana é muito maior que a do rato, e a principal diferença entre elas é que na ATM do animal não há eminência articular, e a fossa glenoide é plana; condição essa que permite amplos movimentos mandibulares protrusivos (Abdrabuh et al, 2020;El-Hakim, Abdel-Hamid, & Bader, 2005;Porto, Vasconcelos, Andrade, & Silva-Junior, 2010).…”

Section: Revisão E Discussão Da Literaturaunclassified

“…Tanto no côndilo humano como no do rato, existe uma espessa camada de cartilagem hialina. Contudo, em humanos, há mais camadas de condrócitos sobrepostos do que na superfície articular do côndilo do animal (Abdrabuh et al, 2020). A superfície articular temporal humana é diferente histologicamente em relação à da ATM do rato, pois apresenta menor número de camadas de condrócitos e uma camada fibrosa mais espessa.…”

Section: Revisão E Discussão Da Literaturaunclassified

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Modelos animais utilizados para o estudo da articulação temporomandibular: revisão de literatura

Cougo

Quevedo

Ponzoni

2021

RSD

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A articulação temporomandibular (ATM) é considerada uma das articulações mais complexas do corpo humano. Está envolvida em múltiplas funções, entre elas a mastigação e a fonação. É considerada uma estrutura extremamente adaptativa. Diversas patologias podem afetar a ATM e resultar em disfunções que interferem significativamente na vida dos pacientes. As disfunções temporomandibulares (DTM) estão associadas a um grande número de etiologias. Os modelos experimentais animais representam uma possibilidade para o estudo anatômico, histológico e fisiológico dessa estrutura, a indução de disfunções e estabelecimento de tratamentos. O objetivo dessa revisão de literatura é apresentar e discutir o uso de modelos animais para o estudo da ATM. A revisão de literatura foi realizada por meio de uma pesquisa bibliográfica nas bases de dados Pubmed (https://pubmed.ncbi.nlm.nih.gov/), Scielo (scielo.org) e Bireme (http://bvsalud.org/). De acordo com a revisão de literatura, até o momento, nenhum modelo animal se assemelha totalmente à ATM humana. Essa característica representa um fator limitante na investigação de possíveis terapêuticas cirúrgicas e não cirúrgicas para as DTMs. Uma vez que, não existe um modelo único, os pesquisadores devem escolher o modelo animal que mais se aplica ao objetivo do estudo a ser realizado.

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Impact of estrogen therapy on temporomandibular joints of rats: Histological and hormone analytical study

Cited by 10 publications

References 20 publications

Analysis of mandible trabecular structure using digital periapical radiographs to assess low bone quality in postmenopausal women

Analysis of mandible trabecular structure using digital periapical radiographs to assess low bone quality in postmenopausal women

Low back pain and osteoarthritis pain: a perspective of estrogen

Modelos animais utilizados para o estudo da articulação temporomandibular: revisão de literatura

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