Impact of Gut Microbiome Lactobacillus spp. in Brain Function and its Medicament towards Alzheimer’s Disease Pathogenesis

Abstract

Alzheimer’s disease is neurodegenerative dementia which has significant health complications in the old age group. An imbalance in gut microbiota can influence to cause several diseases like chronic disorders, depression, type II diabetics, and neurological disorders like AD. Aging is one of the major causes of the development of neurodegenerative disease due to the decreasing levels of neurotransmitters, oxidative stress, chronic inflammation, and apoptosis. These harmful effects of aging can be prevented by probiotics usage. The gut-microbiota is capable to control the brain function through the gut-brain axis. Lactobacillus strains are considered as beneficial microorganism because of its importance of the maintenance in healthy intestinal microflora, immunomodulation, and intestinal pathogenic intervention. They have diverse applications in the medical field with properties like antioxidant, anticancer, anti-inflammatory, anti-proliferative, anti-obesity, and anti-diabetic activities. Probiotic supplementation with Lactobacillus strains shows an optimistic trend to use it as a significant therapy for cognitive symptoms. This review article put forwards the significance of the gut-brain axis and the contribution of Lactobacillus strains as a probiotic supplement and its therapeutic innovations for future aspects and the limitation to treat AD-related pathogenesis are briefly elucidated.

A Bibliometric Review on Gut Microbiome and Alzheimer’s Disease Between 2012 and 2021

“…Some gut microorganisms have already been hypothesized to play a role in the pathogenesis of AD, such as Lactobacillus spp. beneficial to brain functions leading to an optimistic therapy to improve cognitive function ( John et al, 2021 ). Other researchers correlate periodontal hygiene and microbial composition in the mouth to the development of the disease, suggesting a possible therapeutic in the future ( Ryder and Xenoudi, 2021 ).…”

Metabolomics and Microbiomics: New Potential Strategies in Chronic Pain Syndrome

“… Bifidobacterium sp . It regulates growth hormone, immune response, lipolysis, renal function, heart rate, blood pressure Acetylcholine 59 , 60 Lactobacillus sp . It acts on numerous physiological functions, such as regulating cardiac contractions and blood pressure, intestinal peristalsis, glandular secretion, and brain function Aminobutyric acid (GABA) 61 , 62 Lactobacillus sp .…”