Impact of Intraocular Pressure after Filtration Surgery on Visual Field Progression in Primary Open-Angle Glaucoma

Lázaro, Carlos; García‐Feijoó, Julián; Castillo, Alfredo; Perea, Jose; Martinez-Casa, J M; García–Sánchez, J.

doi:10.1177/112067210701700313

Cited by 17 publications

(10 citation statements)

References 42 publications

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“…3,5,19,20 In our study, although we did not conclude a specific IOP the trend test supported the idea that patients with lower early postoperative IOP would have a higher probability to success regardless of the criteria. In addition, IOP exhibited increasing importance in guiding the interventions.…”

Section: Resultssupporting

confidence: 52%

Can early postoperative intraocular pressure predict success following mitomycin-C augmented trabeculectomy in primary angle-closure glaucoma

Rong

Feng

Wang

et al. 2013

Eye

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Purpose To evaluate the association between early and late postoperative intraocular pressure (IOP) and determine if early postoperative IOP can predict the surgical outcome. Methods A total of 165 consecutive patients with primary angle-closure glaucoma (PACG) undergoing primary mitomycin-C-augmented trabeculectomy underwent a comprehensive eye examination before surgery and were followed-up on days 1, 7, 14, and 30, and months 3, 6, 12, and 18. IOPs on days 1, 7, 14, and 30 were stratified into groups A (o10 mm Hg), B (Z10 and o15 mm Hg), C (Z15 and o20 mm Hg), and D (Z20 mm Hg). Differences between groups were analyzed using analysis of variance (ANOVA) and Fisher's exact test. Multivariable regression was used to exam the predictive ability of early IOP for final outcome. Results The mean age was 62.5 ± 7.9 years and 41.21% (n ¼ 68) were males. Stratified by IOP on days 1, 7, 14, and 30, respectively, mean IOPs at month 18 were different among groups A, B, C, and D (ANOVA, P ¼ 0.047, P ¼ 0.033, P ¼ 0.008, and Po0.001, respectively). Once the IOPs were settled with interventions on day 7 a higher IOP level was associated with decreasing success rate under different outcome definitions, final IOP o15 mm Hg (Fisher's exact P ¼ 0.001) and o20 mm Hg (P ¼ 0.039) without medication.Multiple regression showed early IOP predicted final IOP independently from baseline variables. A cutoff value of 13.5 mm Hg on day 7 achieved an accuracy of 80.0 and 57.1% in predicting IOPo15 mm Hg without medication and failure after surgery, respectively. Conclusions The IOP at 18 months following primary antifibrotic-augmented trabeculectomy in PACG patients is associated with and predicted by the postoperative IOPs at 1 month. Control of early IOP to 13.5 or less may provide better outcomes.

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Section: Resultssupporting

confidence: 52%

Can early postoperative intraocular pressure predict success following mitomycin-C augmented trabeculectomy in primary angle-closure glaucoma

Rong

Feng

Wang

et al. 2013

Eye

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“…Lowering the IOP of patients with glaucoma has been shown to reduce the risk of progression and also to delay the onset of progression [21 ]. Visual field progression was less frequent in posttrabeculectomy patients with lower IOP than in those with higher IOP [23]. These studies validate the general consensus that glaucoma progression can be reduced, at least in some patients, by treatments that reduce IOP.…”

Section: Intraocular Pressurementioning

confidence: 65%

Risk factors for primary open angle glaucoma progression: what we know and what we need to know

Rivera

Bell

Feldman

2008

Current Opinion in Ophthalmology

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“…The most important reason why studies did not meet the high quality criteria was their retrospective design (38.3% of studies reviewed). 10,[30][31][32]34,36,38,39,43,48,53,58,59,61,64,[66][67][68][69] In retrospective studies (historical cohorts), the information contained in the registries may be missing (incomplete) or of poor quality (information bias). 16 In contrast, in retrospective studies, progression and exposure to PFs occurs before the actual start of the research.…”

Section: Discussionmentioning

confidence: 99%

Methodologic Quality of Studies on Prognostic Factors for Primary Open-angle Glaucoma Progression Measured by Visual Field Deterioration

Júlvez

Sánchez

Feijoó

et al. 2010

Journal of Glaucoma

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Glaucoma is a chronic, slowly progressing, and asymptomatic optic neuropathic disorder with a great variety of causes that involve gradual retinal ganglion cell axon loss. The disease is the second most common cause of blindness in the industrialized world. Once vision loss develops it is irreversible-although in many cases further loss can be slowed if adequate treatment is provided. If not treated, glaucoma can lead to complete vision loss in the affected eye. Primary open-angle glaucoma (POAG) is the most prevalent form of the disease in the industrialized countries, representing 94% of all glaucomas. In a Spanish study of 569 individuals, the prevalence of POAG was 2.1% (99% confidence interval 1.9%-2.3%) in the age range between 40 and 79 years. Assessing glaucomatous damage progression remains one of the most important and challenging aspects in glaucoma management. In addition, a better understanding of clinical risk factors for glaucoma worsening may help us to develop new strategies to improve glaucoma care. Over the past 2 decades, many studies have addressed the issue of risk factors associated with or predicting for glaucoma progression. Although many studies have attempted to identify the prognostic factors capable of predicting the course of POAG, the results have been varied and in some cases contradictory, and are thus of scant practical utility. This study was designed to evaluate the methodologic quality of the studies published in the literature on the prognostic factors for POAG progression measured by visual field deterioration.

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Impact of Intraocular Pressure after Filtration Surgery on Visual Field Progression in Primary Open-Angle Glaucoma

Abstract: Glaucomatous disease progression is less frequent when IOP is less than or equal to 16 mmHg in all the follow-up visits after trabeculectomy. The results indicate a definite benefit of low IOP in visual field control.

Cited by 17 publications

References 42 publications

Can early postoperative intraocular pressure predict success following mitomycin-C augmented trabeculectomy in primary angle-closure glaucoma

Can early postoperative intraocular pressure predict success following mitomycin-C augmented trabeculectomy in primary angle-closure glaucoma

Risk factors for primary open angle glaucoma progression: what we know and what we need to know

Methodologic Quality of Studies on Prognostic Factors for Primary Open-angle Glaucoma Progression Measured by Visual Field Deterioration

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