Impact of lead intoxication in children with iron deficiency anemia in low- and middle-income countries

Jain, Akshat; Wolfe, Lawrence C.; Jain, Ginee

doi:10.1182/blood-2013-05-500603

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Considering the fact that 99 % of lead after absorption is bound to the erythrocytes and that serum lead half-life is longer than the duration of experiment [27, 28], this is the first confirmation that the absorption of metal ions from ferritin by organisms with proper iron status is inhibited. Usually, lead toxicity is connected with the development of anaemia [28]; however, this was not seen in the DPb group.…”

Section: Resultsmentioning

confidence: 95%

Effect of Iron Status in Rats on the Absorption of Metal Ions from Plant Ferritin

Zielińska‐Dawidziak

Hertig

Staniek

et al. 2014

Plant Foods Hum Nutr

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An isolate of lead-ferritin obtained from soybean seeds sprouted in 25 mM of PbNO3 was introduced into the diet of both iron-deficient and iron non-deficient male rats. After a 21-day administration period, statistical differences in the lead accumulation in the femurs of the rats were noted. Iron-deficient rats accumulated more than four times the amount of lead in their bones than rats without iron-deficiency. No further decrease was observed in haemoglobin concentrations in the groups of animals fed with lead isolates, either iron-deficient or iron non-deficient. Also, no differences in the mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV) were observed at the end of the experiment in the group of iron non-deficient rats fed with lead-ferritin isolate compared to the control group of iron non-deficient rats. In the iron-deficient group fed with lead-ferritin isolate, a small increase in haemoglobin concentrations, MCH, MCV and mean corpuscular haemoglobin concentrations (MCHC) was recorded. The results presented in this paper confirm that lead from the tested preparation—lead ferritin isolate—was better absorbed by those rats with induced iron deficiency anaemia. Additionally, we may also suspect based on the obtained results that absorption of ferritin-iron depends on iron status in the body.Electronic supplementary materialThe online version of this article (doi:10.1007/s11130-014-0413-1) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 95%

Effect of Iron Status in Rats on the Absorption of Metal Ions from Plant Ferritin

Zielińska‐Dawidziak

Hertig

Staniek

et al. 2014

Plant Foods Hum Nutr

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“…Lead (Pb) is an environmental toxicant that causes serious harm to child health [1,2]. Children are highly susceptible to Pb toxicity due to hand-to-mouth behavior, high metal absorption rates, and the nervous system that is still in developing stage [3]. Pb enters the body through ingestion and breathing.…”

Section: Introductionmentioning

confidence: 99%

Screening for Elevated Blood Lead Levels and Related Risk Factors among Thai Children Residing in a Fishing Community

Yimthiang

Waeyang

Kuraeiad

2019

Toxics

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The present study explored environmental and behavioral factors associated with elevated blood lead (Pb) levels in 311 children (151 girls and 160 boys), aged 3–7 years, who lived in a coastal fishing community of the Pakpoon Municipality, Nakhon Si Thammarat, Thailand. The geometric mean for blood Pb was 2.81 µg/dL, ranging between 0.03 and 26.40 µg/dL. The percentage of high blood Pb levels, defined as blood Pb ≥ 5 µg/dL, was 10.0% in boys and 13.9% in girls. Parental occupation in producing fishing nets with lead weights was associated with a marked increase in the prevalence odds ratio (POR) for high blood Pb (POR 17.54, 95%; CI: 7.093, 43.390; p < 0.001), while milk consumption was associated with 61% reduction in the POR for high blood Pb (POR 0.393, 95%; CI: 0.166, 0.931; p = 0.034). High blood Pb was associated with an increased risk for abnormal growth (POR 2.042, 95%; CI: 0.999, 4.174; p = 0.050). In contrast, milk consumption was associated with a 43% reduction in POR for abnormal growth (POR 0.573, 95%; CI: 0.337, 0.976; p = 0.040). After adjustment for age, the mean (standard error of mean, SE) values for blood Pb were 6.22 (0.50) μg/dL in boys and 6.72 (0.49) μg/dL in girls of parents with an occupation in making fishing nets with lead weights. These mean blood Pb values were respectively 2.3 and 2.5 times higher than similarly aged boys and girls of parents with other occupations. These data are essential for setting surveillance and programmes to prevent toxic Pb exposure, especially in children of coastal fishing communities in southern Thailand.

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A microplasma optical emission spectrometry pen for point-of-care diagnosis of child blood lead

Lin

Chen

et al. 2022

Journal of Hazardous Materials

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Impact of lead intoxication in children with iron deficiency anemia in low- and middle-income countries

Cited by 4 publications

References 6 publications

Effect of Iron Status in Rats on the Absorption of Metal Ions from Plant Ferritin

Effect of Iron Status in Rats on the Absorption of Metal Ions from Plant Ferritin

Screening for Elevated Blood Lead Levels and Related Risk Factors among Thai Children Residing in a Fishing Community

A microplasma optical emission spectrometry pen for point-of-care diagnosis of child blood lead

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