Effect of Iron Status in Rats on the Absorption of Metal Ions from Plant Ferritin

Zielińska‐Dawidziak, Magdalena; Hertig, Iwona; Staniek, Halina; Piasecka‐Kwiatkowska, Dorota; Nowak, Krzysztof W.

doi:10.1007/s11130-014-0413-1

Cited by 20 publications

(17 citation statements)

References 31 publications

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“…No statistical differences were observed in the liver coefficients of rats in different groups (Fig. 1c); the similar effect was reported by Zielińska-Dawidziak et al [22]. In summary, no general growth parameters in the REE-Fe groups were significantly different from the normal group, which proves that REE-Fe has positive effect on the healthy state of IDA rats.…”

Section: Organ Coefficients Of Ratssupporting

confidence: 86%

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Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Xiao

Lei

Wang

et al. 2015

Biol Trace Elem Res

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This study aims to investigate the effects of a tripeptide iron (REE-Fe) on iron-deficiency anemia rats. Sprague-Dawley rats were randomly divided into seven groups: a normal control group, an iron-deficiency control group, and iron-deficiency groups treated with ferrous sulfate (FeSO4), ferrous glycinate (Fe-Gly), or REE-Fe at low-, medium-, or high-dose groups. The rats in the iron-deficiency groups were fed on an iron-deficient diet to establish iron-deficiency anemia (IDA) model. After the model established, different iron supplements were given to the rats once a day by intragastric administration for 21 days. The results showed that REE-Fe had effective restorative action returning body weight, organ coefficients, and hematological parameters in IDA rats to normal level. In addition, comparing with FeSO4 or Fe-Gly, high-dose REE-Fe was more effective on improving the levels of renal coefficient, total iron-binding capacity, and transferrin. Furthermore, the liver hepcidin messenger RNA (mRNA) expression in the high-dose group was significantly higher (p < 0.05) than that in the FeSO4 or Fe-Gly group and showed no significant difference (p > 0.05) with the normal control group. The findings suggest that REE-Fe is an effective source of iron supplement for IDA rats and might be exploited as a new iron fortifier.

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Section: Organ Coefficients Of Ratssupporting

confidence: 86%

“…1a). It is often observed that the renal coefficient increased when iron is deficient [22]. The renal coefficient significantly decreased in rats supplemented with REE-Fe.…”

Section: Organ Coefficients Of Ratsmentioning

confidence: 99%

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Xiao

Lei

Wang

et al. 2015

Biol Trace Elem Res

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“…32 In contrast to the liver and spleen, kidney hypertrophy was observed in the rats of the IDA group (II), and this effect was also observed by Chen et al and Zielińska-Dawidziak. 22,32 The kidney coefficient of the Fe-YM1504 groups (IV-VI) significantly decreased compared with the IDA group (II) (P < 0.05). The IDA group not treated, the normal group treated with a standard diet, the FeSO 4 group treated with FeSO 4 (2 mg Fe per kg), the LD-YM1504 group, the MD-YM1504 group and the HD-YM1504 group treated with the Fe-YM1504 at 0.5, 2 and 4 mg Fe per kg respectively.…”

Section: Organ Coefficient Changessupporting

confidence: 66%

Effects of Fe-YM1504 on iron deficiency anemia in rats

et al. 2016

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Iron deficiency anemia (IDA) is one of the most serious forms of malnutrition. It is possible that some strains present in the natural environment possess a higher tolerance to inorganic iron and a higher ability to convert and accumulate iron compared with Saccharomyces cerevisiae wild-type strain. In the present study, the strain no. YM1504, able to grow in an iron-rich environment, was used as a potential organic iron supplement, and its efficacy in alleviating IDA in rats was investigated. Sixty female weanling Sprague-Dawley rats were randomly divided into a normal control group fed with a standard diet and a model group fed with an iron-deficient diet to create the IDA model. After the model was established, IDA rats were further randomly divided into five subgroups: the IDA group, the ferrous sulfate (FeSO4) group and Fe-YM1504 low-, medium- or high-dose groups receiving different concentrations of Fe-YM1504 supplements. Our results showed that Fe-YM1504 has an effective restorative function by returning the hemoglobin (Hb), hematocrit (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), serum iron (SI), total iron binding capacity (TIBC), serum ferritin (SF), etc. in IDA animals to the normal level. Moreover, malondialdehyde and the enzyme activities of superoxide dismutase and glutathione peroxidase in both plasma and liver homogenate were improved. Finally, compared with the FeSO4 group, the Fe-YM1504 middle-dose was more effective in alleviating IDA and fewer side effects were observed. The present study indicated that iron-enriched strain no. YM1504 might play a significant role in ameliorating IDA rats and might be exploited as a new iron supplement.

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“…Rats fed with IDD exhibited reduced consumption compared to rats fed with BD (control) (p < 0.05). It is known that one of the most Statistical differences were determined by the student's t-test (p < 0.05) for the depletion period and ANOVA (Dunnett, p < 0.05) for the recovery period common effects of iron deficiency is anorexia and that deficient animals can lose weight [36]. During the recovery period, the amount of food consumed increased in animals re-fed with BD but not in the groups re-fed with BLSD or FSSD.…”

Section: Resultsmentioning

confidence: 99%

Common Bean Leaves as a Source of Dietary Iron: Functional Test in an Iron-Deficient Rat Model

Martínez-Zavala

Mora-Avilés

Anaya‐Loyola

et al. 2016

Plant Foods Hum Nutr

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Recent findings made by our group indicate that the iron content in Phaseolus vulgaris leaves is at least four times greater than in grains therefore, we evaluated the effect of supplementation with bean leaf (iron content of 275 mg/kg on a dry basis) in iron-deficient rats. Anemia was induced by feeding rats with an iron-deficient diet (IDD) for 11 days and iron-recovery diets were subsequently tested for 14 days using a normal diet, a 10 % bean leaf-supplemented IDD (BLSD) or a ferrous sulfate-supplemented IDD. Decreased levels of leukocytes (64 %), erythrocytes (30 %), lymphocytes (62 %), granulocytes (72 %), hematocrit (34 %), hemoglobin (35 %), and ferritin (34 %) were observed in the iron-deficient rats compared to the control rats. BLSD supplementation showed the highest recovery values relative to those recorded for control rats: leukocytes (40 %), erythrocytes (24 %), lymphocytes (33 %), granulocytes (88 %), hematocrit (17 %), and hemoglobin (18 %), suggesting that common bean leaves could be a good source of bioavailable iron with possible immunomodulatory effects.

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Effect of Iron Status in Rats on the Absorption of Metal Ions from Plant Ferritin

Cited by 20 publications

References 31 publications

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Effects of Fe-YM1504 on iron deficiency anemia in rats

Common Bean Leaves as a Source of Dietary Iron: Functional Test in an Iron-Deficient Rat Model

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