Impact of Metabolic Syndrome Risk Factors in First-Degree Relatives of Type 2 Diabetic Patients

Siewert, Susana; Filipuzzi, Sergio; Codazzi, L.; González, Irma; Ojeda, Marta Susana

doi:10.1900/rds.2007.4.177

Cited by 11 publications

(12 citation statements)

References 19 publications

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“…This may help to establish more widespread screening health camps directed particularly to this high risk population. [33], with 95% confidence level, and a bound of error of ± 8%, the estimated sample size was 367. For sample size calculation for the factors associated with the metabolic syndrome in relatives of type 2 diabetics, the prevalence of risk factors was taken as 50%, using a two sided alpha of 0.05, with range of factors among non-exposed group of 46-100 %, odds ratio of 2, with 80% power.…”

Section: Introductionmentioning

confidence: 99%

“…This hypothetically places the spouse at a risk for the presence of the metabolic syndrome, irrespective of consanguity. There have been studies looking at the metabolic syndrome in the first degree relatives of type 2 diabetics conducted in Argentina [33] and Iran [34]. However, to our knowledge, no major study in our region of Pakistan has looked at this specifically.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Metabolic Syndrome in Relatives of Patients with Type 2 Diabetes

Rizwan¹

2018

EMIJ

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Submit Manuscript | http://medcraveonline.com to the same physical measurements and blood testing as the index groups.Results: Of the 230 siblings enrolled, complete data was available for 197. Mean age of index sibling, (n=112) was 34 ± 10.7; referent: (n=85)35.7±10.5 (p=0.24). Of 230 spouses enrolled, complete data was available for 187 spouses-mean age of index spouse, (n=84), was 49.6±11.0; referent: (n=103) 48.7±9.3 (p=0.1). No significant association in overall prevalence of MS in sibling and spouse of individuals with DM2, versus sibling and spouse of non-diabetics was found. There was significant association of high waist circumference in both siblings [1.04(1.006-1.07)] and spouses [1.03(1.007-1.06)] of diabetics versus referents. Conclusion:Abdominal obesity needs to be an integral aspect of cardiovascular disease (CVD) risk assessment. Health care providers need to incorporate spousal history of CVD and DM2 when taking family history from presenting patient. Advice regarding lifestyle modification is best targeted at the couple together, even if one partner appears to be nondiseased. Keywords: Research ArticleEndocrinol Metab Int J 2018, 6(1): 00158 AbstractBackground: Type 2 diabetes and overweight and obesity rates have reached epidemic proportions. Metabolic syndrome (MS) constitutes a cluster of conditions characterized by abdominal obesity, dysglycemia and hypertension. There is a scarcity of data on metabolic parameters of nongenetically related family members of subjects with type 2 diabetes (DM2) in Pakistan. These members may well be sharing unhealthy lifestyles with their diabetic spouse. We aimed to estimate prevalence of MS in blood and non blood relatives of patients known to have DM2, presenting to the diabetes clinic.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of Metabolic Syndrome in Relatives of Patients with Type 2 Diabetes

Rizwan¹

2018

EMIJ

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“…A greater probability to acquire T2DM was seen among offspring of single diabetic parents and offspring of both diabetic parents compared to those of non-diabetic parents in Framingham population [18,19]. Offsprings of FHD (Family history of diabetes) showed an increased risk in western world [20,21] with an age range of 35-45 year olds except that there are few studies in young asian offspring [22].…”

Section: Introductionmentioning

confidence: 99%

Serum Insulin and Insulin Resistance in the Off-Springs of Type 2 Diabetes Mellitus

Rahim¹,

Rahim²

2014

J Diabetes Metab

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“…In spite of the presence of many genetic variants that are linked to the risk of developing diabetes, their clinical usefulness to estimate the risk for diabetes in the population is limited. 7,8 Well established risk factors for type 2 diabetes include age, sex, obesity physical inactivity, dyslipidemia and family history. 9 Studies in U.S. population have shown a graded and independent role for the family history as a risk for developing type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of dysglycaemia and other cardiovascular risk factors among first degree relatives of Irish patients with type 2 diabetes in Ireland

Fedail¹

2019

EMIJ

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Objectives: To assess the prevalence of diabetes, pre-diabetes and other cardiovascular risk factors amongst close relatives of patients with type2 diabetes. Methods: 100 participants aged between 25 and 75 years were recruited through their first degree relatives, who have type 2diabetes and attend Naas Hospital diabetes clinic. Participants underwent an oral glucose tolerance test, cardiovascular risk factor assessment and completed a questionnaire. Results: 60% of participants were females with a mean age of 45.9 years, 95% CI (44.08-47.8). 21% had dysglycaemia (One with diabetes and 20 pre-diabetes). 34% had un-diagnosed hypertension and 8% were known hypertensive but not controlled. 71% had dyslipidaemia.23% were overweight, while 38% were obese. Fasting blood glucose correlated positively with age (p=0.047), BMI (p=0.02), systolic BP (p=0.003) and triglycerides levels (p=0.023). Conclusion: First degree relatives of type 2 diabetes patients showed relatively low prevalence of dysglycaemia, but a high prevalence of dyslipidaemia, hypertension and obesity.

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Impact of Metabolic Syndrome Risk Factors in First-Degree Relatives of Type 2 Diabetic Patients

Abstract: This study revealed that the prevalence of MetS is high in young FDR adults, who need urgent preventive treatment, including lifestyle changes. The risk of developing T2DM is five times higher in non-diabetic people with MetS than in those without the syndrome.

Cited by 11 publications

References 19 publications

Prevalence of Metabolic Syndrome in Relatives of Patients with Type 2 Diabetes

Prevalence of Metabolic Syndrome in Relatives of Patients with Type 2 Diabetes

Serum Insulin and Insulin Resistance in the Off-Springs of Type 2 Diabetes Mellitus

The Prevalence of dysglycaemia and other cardiovascular risk factors among first degree relatives of Irish patients with type 2 diabetes in Ireland

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