Impact of photon counting detector CT derived virtual monoenergetic images and iodine maps on the diagnosis of pleural empyema

Jungblut, Lisa; Abel, Frederik; Nakhostin, Dominik; Mergen, Victor; Sartoretti, Thomas; Euler, André; Frauenfelder, Thomas; Martini, Katharina

doi:10.1016/j.diii.2022.09.006

Cited by 21 publications

(9 citation statements)

References 30 publications

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“…Instead, they must be shown to have a positive impact on diagnostic accuracy and diagnostic confidence, and ideally to change the clinical management of patients. Initial studies already show an impact on diagnostic performance and diagnostic accuracy in various clinical fields, 46 , 68 , 77 , 86 , 87 and larger, more comprehensive clinical studies are sure to follow.…”

Section: Discussionmentioning

confidence: 99%

Technical Basics and Clinical Benefits of Photon-Counting CT

Flohr

Schmidt

2023

Invest Radiol

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Novel photon-counting detector CT (PCD-CT) has the potential to address the limitations of previous CT systems, such as insufficient spatial resolution, limited accuracy in detecting small low-contrast structures, or missing routine availability of spectral information. In this review article, we explain the basic principles and potential clinical benefits of PCD-CT, with a focus on recent literature that has grown rapidly since the commercial introduction of a clinically approved PCD-CT.

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Section: Discussionmentioning

confidence: 99%

Technical Basics and Clinical Benefits of Photon-Counting CT

Flohr

Schmidt

2023

Invest Radiol

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“…Regarding image acquisition, the most remarkable advances in imaging of GISTs relate to the use of dual-energy CT. Dual-energy CT is used to calculate iodine concentration in a given tissue and has several advantages over single-energy CT. 16,17 In this regard, dual-energy CT conveys greater stability of attenuation measurements and iodine quantification, which are important issues for identifying mild enhancement in GISTs. The benefit of dual-energy CT has been assessed in patients with GISTs.…”

Section: Image and Data Acquisitionmentioning

confidence: 99%

CT and MRI of Gastrointestinal Stromal Tumours: New Trends and Perspectives

et al. 2023

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Gastrointestinal stromal tumors (GISTs) are defined as mesenchymal tumors of the gastrointestinal tract that express positivity for CD117, which is a c- KIT proto-oncogene antigen. Expression of the c- KIT protein, a tyrosine kinase growth factor receptor, allows the distinction between GISTs and other mesenchymal tumors such as leiomyoma, leiomyosarcoma, schwannoma and neurofibroma. GISTs can develop anywhere in the gastrointestinal tract, as well as in the mesentery and omentum. Over the years, the management of GISTs has improved due to a better knowledge of their behaviors and risk or recurrence, the identification of specific mutations and the use of targeted therapies. This has resulted in a better prognosis for patients with GISTs. In parallel, imaging of GISTs has been revolutionized by tremendous progress in the field of detection, characterization, survival prediction and monitoring during therapy. Recently, a particular attention has been given to radiomics for the characterization of GISTs using analysis of quantitative imaging features. In addition, radiomics has currently many applications that are developed in conjunction with artificial intelligence with the aim of better characterizing GISTs and providing a more precise assessment of tumor burden. This article sums up recent advances in computed tomography and magnetic resonance imaging of GISTs in the field of image/data acquisition, tumor detection, tumor characterization, treatment response evaluation, and preoperative planning.

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“…At low-energy, that is, 40 keV, VMI enables an increase in CT attenuation of iodine and more generally of tissue with high photoelectric absorption. This improves contrast-to-noise ratios of enhanced lesions or vessels 55,56 and decreases the iodine load for a satisfactory level of vessel opacification 57–59 . At higher energy than 70 keV, VMI enables a reduction of beam-hardening like-artifacts, thus improving the visualization of tissues surrounding high-attenuating tissues, iodinated vessels, 60 or metallic structures such as stents or prostheses 61,62 .…”

Section: Clinical Applicationsmentioning

confidence: 99%

First Experience With a Whole-Body Spectral Photon-Counting CT Clinical Prototype

et al. 2023

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Spectral photon-counting computed tomography (SPCCT) technology holds great promise for becoming the next generation of computed tomography (CT) systems. Its technical characteristics have many advantages over conventional CT imaging. For example, SPCCT provides better spatial resolution, greater dose efficiency for ultra-low-dose and low-dose protocols, and tissue contrast superior to that of conventional CT. In addition, SPCCT takes advantage of several known approaches in the field of spectral CT imaging, such as virtual monochromatic imaging and material decomposition imaging. In addition, SPCCT takes advantage of a new approach in this field, known as K-edge imaging, which allows specific and quantitative imaging of a heavy atom-based contrast agent. Hence, the high potential of SPCCT systems supports their ongoing investigation in clinical research settings. In this review, we propose an overview of our clinical research experience of a whole-body SPCCT clinical prototype, to give an insight into the potential benefits for clinical human imaging on image quality, diagnostic confidence, and new approaches in spectral CT imaging.

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Impact of photon counting detector CT derived virtual monoenergetic images and iodine maps on the diagnosis of pleural empyema

Cited by 21 publications

References 30 publications

Technical Basics and Clinical Benefits of Photon-Counting CT

Technical Basics and Clinical Benefits of Photon-Counting CT

CT and MRI of Gastrointestinal Stromal Tumours: New Trends and Perspectives

First Experience With a Whole-Body Spectral Photon-Counting CT Clinical Prototype

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