Impact of Poria Cocos Nanoparticles Extract Against Ehrlich Solid Tumour Induced Toxicity, Oxidative Stress and Apoptosis in Female Mice Kidney

Tousson, Ehab; El-Aleim, H. Abd; Elabd, Mervat; Karhib, Mustafa; Gebreel, Doaa T.

doi:10.13005/bpj/2531

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…Chamomile flowers weighing 5 grams plus 95 ml of boiled distilled water were used to make the extract in a flask. After 12 h, the suspension was filtered through filter paperand was freshly used (Ibrahim and Butris, 2008;Tousson, 2019).…”

Section: Extract Preparationmentioning

confidence: 99%

Effects of Chamomile Aqueous Extract on Productive Performance, Egg Quality, and Serum Biochemical Parameters in Laying Japanese Quails

Ezeldien¹,

Dramou²,

Fatma³

et al. 2023

AAVS

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| Chamomile, Matricaria chamomilla L., is one of the most popular medicinal plants known for its antibacterial, anti-inflammatory, and antioxidant properties. This study was conducted to determine the effect of chamomile aqueous extract on the productivity, egg quality, and serum biochemical parameters of laying Japanese quail. A total of 42 Japanese quail were separated into two groups of 21 birds each, with three replicates per group (7 birds) at random; the control group without any additives and the supplemented group with chamomile aqueous extract (3ml/L) in the drinking water from 2 weeks to 13 week at the end of expermint. The total phenols, flavonoids, , and antioxidant potential of chamomile extract were all assayed. The results showed that the chamomile aqueous extract is rich in phenolic(108.92 μg/ml) and flavonoid (66.41 μmol/ml ) compounds. Additionally, chamomile extract is a potent antioxidant(1.77 ng/ ml). Laying quails supplemented with chamomile aqueous extract showed increased body weight and egg mass, as well as a lowered feed conversion ratio. Chamomile extract significantly increased serum levels of total protein and albumin while decreasing glucose level compared to the control group. Eggs of Japanese quail supplemented with chamomile extract showed a higher egg weight, egg length, albumen weight, albumen length, and yolk index. It could be concluded that the chamomile aqueous extract can positively affect the egg quality and productivity of laying Japanese quail.

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Section: Extract Preparationmentioning

confidence: 99%

Effects of Chamomile Aqueous Extract on Productive Performance, Egg Quality, and Serum Biochemical Parameters in Laying Japanese Quails

Ezeldien¹,

Dramou²,

Fatma³

et al. 2023

AAVS

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“…For convenient research into the anti-cancer properties of several chemical compounds, the Ehrlich tumour (EST and EAC) has been adopted as a transplantable tumour model (Abd Eldaim et al, 2019;2021a;Oshiba et al, 2021). Ehrlich Ascites Carcinoma (EAC) also known as an undifferentiated carcinoma, is initially hyperdiploid, highly transplantable, never regresses, proliferates quickly, has a shorter life span, and is completely malignant (Mutar et al, 2020;Alotaibi et al, 2021;Tousson et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Impact of B-Glucan Against Ehrlich Ascites Carcinoma Induced Renal Toxicity in Mice

Hasan¹,

Alankooshi²,

Abbood³

et al. 2023

OnLine Journal of Biological Sciences

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Several studies have been focused on identifying alternative medicines for the treatment of cancer. This study aimed to investigate the impact of B-Glucans extract (BG) against Ehrlich Ascites Carcinoma (EAC) induced toxicity and tissue damage in kidney. A total of 40 mice were assigned randomly to four groups (G1, control; G2, B-Glucans (75 mg/kg bw/day) orally for 2 weeks; G3, EAC and G4, EAC + BG). Current results revealed, EAC induced significant elevation in urea, creatinine, potassium (k + ), chloride (Cl -) ions, kidney injury and significant decrease in sodium (Na + ) and calcium (Ca ++ ) ions when compared to B-glucans and control groups. Conversely, EAC + B-glucans modulate these changes and improved the renal functions and structure. EAC induced renal dysfunction and B-Glucans has the ability to improve renal functions. We can conclude that; BG could be used as an adjuvant therapy for kidney in ascites of hepatocellular carcinoma, Schistosoma and hepatitis.

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Ameliorating and Therapeutic Impact of Curcumin Nanoparticles Against Aluminum Oxide Nanoparticles Induced Kidney Toxicity, DNA Damage, Oxidative Stress, PCNA and TNFα Alteration in Male Rats

Tousson,

El‐Sayed,

Elsharkawy

et al. 2024

Environmental Toxicology

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Aluminum oxide nanoparticles (Al2O3 NPs) are among the most extensively utilized nanoparticles in nanotechnology and that have negative impacts on the environment. Therefore, the intention of this work is to investigate the protective and therapeutic effects of curcumin in nanoform (Cur NPs) against Al2O3 NPs induced kidney toxicity, oxidative stress, DNA damage, and changes in necrosis factor alpha (TNFα) and proliferating cell nuclear antigen (PCNA) expressions in male rats. Fifty healthy adult male were divided into five groups [G1, control; G2, received 50 mg/kg/day for 4 weeks of Cur NPs orally; G3, received 6 mg/kg BW orally for 4 weeks of Al2O3 NPs; G4, (Cur NPs + Al2O3 NPs) received Cur NPs and Al2O3 NPs at a dose similar to G2 and G3, respectively for 4 weeks; G5, (Al2O3 NPs + Cur NPs) received Al2O3 NPs at a dose similar to G3 for 4 weeks then received Cur NPs at a dose similar to G2 for another 4 weeks]. Current results revealed that Al2O3 NPs induced a significant elevation in serum urea, creatinine, chloride, calcium, kidney malondialdehyde (MDA), DNA damage, injury, TNFα and PCNA expressions and a significant depletion in serum potassium, kidney superoxide dismutase (SOD), glutathione (GSH) as compared to control. On the other hand, treatments of Al2O3 NPs with Cur NPs induced modulation in all altered parameters and improved kidney functions and structure, with best results for the Al2O3 NPs + Cur NPs than Cur NPs + Al2O3 NPs. In conclusion, Cur NPs has the capacity to mitigate the renal toxicity induced by Al2O3 NPs in male albino rats.

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Impact of Poria Cocos Nanoparticles Extract Against Ehrlich Solid Tumour Induced Toxicity, Oxidative Stress and Apoptosis in Female Mice Kidney

Cited by 3 publications

References 29 publications

Effects of Chamomile Aqueous Extract on Productive Performance, Egg Quality, and Serum Biochemical Parameters in Laying Japanese Quails

Effects of Chamomile Aqueous Extract on Productive Performance, Egg Quality, and Serum Biochemical Parameters in Laying Japanese Quails

Impact of B-Glucan Against Ehrlich Ascites Carcinoma Induced Renal Toxicity in Mice

Ameliorating and Therapeutic Impact of Curcumin Nanoparticles Against Aluminum Oxide Nanoparticles Induced Kidney Toxicity, DNA Damage, Oxidative Stress, PCNA and TNFα Alteration in Male Rats

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