Impact of Prostate Weight on Probability of Positive Surgical Margins in Patients With Low-risk Prostate Cancer After Robotic-assisted Laparoscopic Radical Prostatectomy

Marchetti, P.; Shikanov, Sergey; Razmaria, Aria; Zagaja, Gregory P.; Shalhav, Arieh L.

doi:10.1016/j.urology.2010.07.512

Cited by 30 publications

(25 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[13][14][15][16][17][18] However, much of the data used to derive rates of PSM are based on information from single institutions and tertiary care centres of excellence. They are, therefore, of limited utility to the practicing urologist who is seeking to compare his or her own results against a normative sample.…”

Section: Introductionmentioning

confidence: 99%

Positive surgical margins at radical prostatectomy: Population-based averages within PSA and Gleason strata

Izard

Salazar

Chatterjee

et al. 2013

CUAJ

View full text Add to dashboard Cite

Background: Positive surgical margins (PSM) are an important determinant of biochemical recurrence after radical prostatectomy (RP). We use a population-based cancer registry to evaluate PSM by stage, Gleason and prostate-specific antigen (PSA). Methods: We identified men undergoing RP from the Surveillance, Epidemiology and End Results (SEER) database between 2004 and 2007. Differences between those with and without PSM were compared with chi-squared tests. The proportion of cases with PSM were stratified by PSA and Gleason sum for both pT2 and pT3a tumours. Factors associated with PSM were analyzed using chi square and multivariate logistic regression analysis. A composite variable was used in a second multivariate analysis to display the odds ratio (OR) for a PSM for each discrete combination of PSA, Gleason score and pT stage Results: In total, 28 461 RP patients were identified and a PSM was present in 19.5%. PSM were 42% in pT3a and 16% in pT2 cases. Higher PSAs (<4.0, 4-9.9, >10) were associated with higher proportions of PSM (12%, 20% and 28%, p < 0.001). Similarly, higher Gleason scores (≤6, 3+4, 4+3, ≥8) were associated with higher PSM (12%, 22%, 27% and 33%, p < 0.001). For pT2 tumours, the proportion of PSM ranged from 8% (Gleason ≤6, PSA <4.0) to 28% (Gleason 8-10, PSA ≥10). For pT3a tumours, the PSM was higher in each Gleason/PSA strata compared to those with pT2 tumours, reaching 63% for those with pT3a, Gleason 8-10, PSA >10 disease. On multivariate analysis, stage was the largest predictor for PSM (OR 3.05, 95% confidence interval 2.81-3.30), although Gleason score and PSA remained statistically significant. Conclusion: In this population-based study of PSM after RP, the proportion of PSM vary significantly within different PSA and Gleason strata for organ-confined and extracapsular disease. These data can be used as a reference for urologist self-assessment.

show abstract

Section: Introductionmentioning

confidence: 99%

Positive surgical margins at radical prostatectomy: Population-based averages within PSA and Gleason strata

Izard

Salazar

Chatterjee

et al. 2013

CUAJ

View full text Add to dashboard Cite

show abstract

“…Despite prolonged operative times in patients with prostate volumes greater than 75 g, they found lower rates of surgical margin positivity. Similarly, Marchetti et al [11] reported the outcomes of their 690 patients who had undergone RRP, and indicated that lower prostate volume was associated with increased rates of surgical margin positivity. In our study, higher rates of surgical margin positivity in patients with lower prostate volumes relative to the other groups were not statistically significant (p=0.066).…”

Section: Discussionmentioning

confidence: 98%

The effect of prostate weight on the outcomes of robot-assisted radical prostatectomy

Boylu

Turan

Başataç

et al. 2013

Turkish Journal of Urology

View full text Add to dashboard Cite

Objective: The effect of prostate volume on the surgical, functional, and oncological outcomes of robot assisted radical prostatectomy (RARP) was evaluated. Material and methods:A total of 180 patients who underwent RARP and had at least a 1-year follow-up were included. The patients were divided into 3 groups based on prostate weight (Group 1: <45 g, Group 2: 45-75 g, and Group 3: >76 g). Erectile function and continence were evaluated at 3, 6, 9, and 12 months postoperatively. The International Index of Erectile Dysfunction (IIEF) score and daily pad usage were evaluated as indicators of erectile function and continence, respectively. The measurement of two prostatespecific antigen (PSA) values over 0.2 ng/mL was considered biochemical disease recurrence. Results:Patients with larger prostates were older and had a longer operative time and higher PSA level compared with patients with smaller prostates (p<0.05). The positive surgical margin rate was higher in patients with smaller prostates (p=0.06). However, patients with a prostate weight <45 g had higher IIEF scores at 3 and 6 months. IIEF scores were similar at the end of the 1-year follow-up period. Pad usage and time to continence were higher in patients with larger prostates (p>0.05). Conclusion:Although prostate weight affected the surgical outcomes of RARP, the functional and oncological outcomes were similar among all patients. Long-term follow-up is needed to determine their impact on oncological outcomes.

show abstract

“…Link et al [18] and Marchetti et al [19] indicated decrease in prostate volume as an independent predictive factor for surgical margin positivity. Link et al [18] performed robotic radical prostatectomy on 1847 patients, Then the patients were categorized according to their prostate volumes as 0-30 g, 30-50 g, 50-70 g, and ≥70 g, and the effect of prostate volumes on surgical margin positivity was investigated.…”

Section: Discussionmentioning

confidence: 98%

Predictive preoperative factors of positivesurgical margins after robotic radical prostatectomy in low-risk prostate cancer

Turan

Boylu

Başataç

et al. 2013

Turkish Journal of Urology

View full text Add to dashboard Cite

Objective: Positive surgical margins after radical prostatectomy for localized prostate cancer is a powerful predictor of PSA recurrence. Clinical stage, Gleason score and preoperative PSA are predictive factors for positive surgical margin after radical prostatectomy. In this study, we aimed to identify preoperative factors affecting surgical margin positivity in low-risk prostate cancer after robotic radical prostatectomy (RARP). Material and methods:Between 2008 and 2011 (

show abstract

Impact of Prostate Weight on Probability of Positive Surgical Margins in Patients With Low-risk Prostate Cancer After Robotic-assisted Laparoscopic Radical Prostatectomy

Cited by 30 publications

References 28 publications

Positive surgical margins at radical prostatectomy: Population-based averages within PSA and Gleason strata

Positive surgical margins at radical prostatectomy: Population-based averages within PSA and Gleason strata

The effect of prostate weight on the outcomes of robot-assisted radical prostatectomy

Predictive preoperative factors of positivesurgical margins after robotic radical prostatectomy in low-risk prostate cancer

Contact Info

Product

Resources

About