Impact of smoking history on postoperative complications after lung cancer surgery – a study based on 286 cases

Abstract

Aim The aim of the study was to evaluate the impact of smoking cessation and its timing in the preoperative period on postoperative morbidity in patients undergoing surgery for non-small cell lung cancer (NSCLC). Material and methods Two hundred and eighty-six patients surgically treated for NSCLC were prospectively analyzed in terms of duration and intensity of smoking, time period from smoking cessation to surgery, and postoperative morbidity. The patients were divided into five groups: I – current smokers and past smokers who quit smoking less than 2 weeks before surgery ( n = 67), II – past smokers who quit 2 weeks to 3 months ( n = 106), III – past smokers who quit 3 months to 1 year ( n = 30), IV – past smokers who quit more than 1 year ( n = 71), V – never smokers ( n = 12). Results In the analyzed group 95.8% were smokers or past smokers. Postoperative complications occurred in 40.2% of patients including pulmonary (21.3%) and cardiac morbidity (17.8%). The pulmonary and circulatory morbidity rates were the lowest in group V but the differences were not significant. Similarly, there were no significant differences between groups with and without pulmonary or circulatory complications regarding: number of daily smoked cigarettes, smoking duration and the moment of cessation. The analysis of segmental regression showed the smallest percentage of complications in patients who quit smoking between the 8 th and the 10 th week before the operation. Conclusions Among patients surgically treated for NSCLC, duration of smoking and number of smoked cigarettes has no significant influence on frequency and type of postoperative complications. The best moment to quit smoking is the period between the 8 th and the 10 th week preceding surgery.

Exercise intervention as a protective modulator of dyslipidemia in men cigarette smokers

“…Smoking may also increase pulmonary and circulatory morbidity following a variety of surgery interventions that are due to chronic bronchitis and tobacco-induced atherosclerosis of coronary arteries. Postoperative complications, according to several authors, occur 1.4-4.3 times more frequently among smokers as compared with non-smokers [31].…”

Predictors of 30-Day Pulmonary Complications after Video-Assisted Thoracoscopic Surgery Lobectomy

“…The tobacco use metric in this study was recorded in binary fashion, with patients tabulated on the basis of whether they had endorsed active smoking within the year prior to surgery. Given that smoking cessation improves surgical outcomes, even within weeks of surgery, 12 39 this metric may have inadequately captured the timeline of tobacco use in our population. We therefore continue to feel that an emphasis on preoperative smoking cessation is critical to ensuring favorable surgical outcomes, both in our veteran population and in the population at large.…”

Expression and clinical significance of microRNA‑21, PTEN and p27 in cancer tissues of patients with non‑small cell lung cancer

“…The World Health Organization (WHO) estimates that lung cancer is the cause of 1.37 million deaths worldwide each year and that 71% of these deaths are caused by smoking, indicating that ~400,000 people die of lung cancer each year ( 15 ). Because the etiology and pathogenesis of PHC have not been determined yet, some studies ( 16 – 18 ) have shown that the diagnosis of NSCLC by genetic index is more reliable and the detection method is convenient. Therefore, it is very important to find an index that can accurately reflect the occurrence, progression and change of NSCLC and a convenient means of detection.…”