2019
DOI: 10.1016/j.micpath.2019.05.022
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Impact of specific inhibitors on metallo-β-carbapenemases detected in Escherichia coli and Klebsiella pneumoniae isolates

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Cited by 18 publications
(15 citation statements)
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“…Besides, resistance to meropenem in the clinical and the environmental isolates (12.5% vs 24.2%, respectively) was higher than imipenem (6.9% vs 0%, respectively). In contrast, Abbas et al, 2019 reported that two E. coli (0.6%) and 15 Klebsiella pneumoniae (5%) out of 300 clinical isolates were carbapenem-resistant [26]. The increased resistance to cephalosporins may be attributed to the worldwide use of this class of antibiotics while carbapenems are still active in the treatment of serious infections [27].…”
Section: Discussionmentioning
confidence: 99%
“…Besides, resistance to meropenem in the clinical and the environmental isolates (12.5% vs 24.2%, respectively) was higher than imipenem (6.9% vs 0%, respectively). In contrast, Abbas et al, 2019 reported that two E. coli (0.6%) and 15 Klebsiella pneumoniae (5%) out of 300 clinical isolates were carbapenem-resistant [26]. The increased resistance to cephalosporins may be attributed to the worldwide use of this class of antibiotics while carbapenems are still active in the treatment of serious infections [27].…”
Section: Discussionmentioning
confidence: 99%
“…However, metallo-carbapenemases cannot be clinically inhibited but can be inhibited in vitro by chelating agents such as ethylene diamine tetraacetic acid (EDTA) and mercaptopropionic acid (MPA). 12,13 BOX-PCR is a DNA fingerprinting technique that detects repetitive and highly conserved DNA elements located on the bacterial chromosome. 14 These repeated conserved DNA elements were termed BOX dispersed-repeat motifs that were first identified on the chromosome of Streptococcus pneumoniae.…”
Section: Introductionmentioning
confidence: 99%
“…Representative DNA fingerprint pattern generated by BOX-PCR for carbapenem-resistant K. pneumoniae clinical isolates. L, 100 bp DNA ladder; lanes 3, 4,5,6,7,8,9,10,11,12,13,14,15,16,17, and 18 are the code No. of CRKP clinical isolates.…”
mentioning
confidence: 99%
“…9 The class B β-lactamases identified in K. pneumoniae have also been found in other Enterobacteriaceae worldwide. 10 The majority of NDM-1-producing K. pneumoniae strains also carried a diversity of other resistance genes but mostly remained susceptible to agents such as colistin, fosfomycin, and tigecycline. 8,11 These different carbapenemase genes circulating within K. pneumoniae are often associated with mobile structures, including insertion sequences (IS), plasmids, and transposons, which caused serious challenges to clinic treatment.…”
Section: Introductionmentioning
confidence: 99%