Impact of structural features of Sr/Fe co-doped HAp on the osteoblast proliferation and osteogenic differentiation for its application as a bone substitute

Ullah, Ismat; Zhang, Wancheng; Yang, Liang; Ullah, Muhammad Wajid; Atta, Omar Mohammad; Khan, Suliman; Wu, Bin; Wu, Tianjun; Zhang, Xianglin

doi:10.1016/j.msec.2020.110633

Cited by 57 publications

(34 citation statements)

References 55 publications

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“…The data in Figs. 2 and 3 agree well with above statement and confirm that in all samples (up to maximal concentration of 20 at.%) Zr [20], Ullah et al [21] and Perez et al [22]. The parti-cle size of the HAp-based nanoparticles prepared in this study corresponds to the particle size of those prepared by Chen et al [4].…”

Section: Xrd Analysessupporting

confidence: 89%

Hydrothermally synthesis and characterization of HAp and Zr-doped HAp nanoparticles from bovine bone and zircon for photodynamic therapy

Gustaman

Hadi

Kurniawan

et al. 2021

PAC

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HAp and Zr-doped HAp nanoparticles were synthesized from bovine bone and local zircon material by using the hydrothermal method. XRD analysis showed that the HAp and Zr-doped HAp nanoparticles had hexagonal structure with a crystallite size of 20-36 nm and the lattice constants a = 9.8-9.9? and c = 6.5-6.8 ?. XRD data also showed that up to 20 at.% of Zr can be accommodated in HAp crystal structure. The lattice constant and cell volume decreased with increasing Zr concentration. FTIR data confirmed that the majority of functional groups that exist on the surface of the HAp and Zr-doped HAp nanoparticles were the hydroxyl and phosphate groups. Suspensions with the HAp and Zr-doped HAp nanoparticles prepared using citric acid as dispersant were stable with zeta potential between ?31 and ?35mV at pH = 7. Reactive oxygen species are generated on the produced HAp and Zr-doped Hap nanoparticles and confirm their potential for application in photodynamic therapy.

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Section: Xrd Analysessupporting

confidence: 89%

Hydrothermally synthesis and characterization of HAp and Zr-doped HAp nanoparticles from bovine bone and zircon for photodynamic therapy

Gustaman

Hadi

Kurniawan

et al. 2021

PAC

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“…There are limited studies that evaluate bone cell cytotoxicity when cultured in the presence of iron ions that may be caused by induced ROS production leading to disruption of cell membrane integrity [59]. This suggests that iron-doped nanofiber can work as an antibacterial effect, which is in agreement with the previous reported work [34]. Figure 8a-c shows preconditioned medium prepared using CA mats confirmed a low level of positive EthD-1 staining signals after 7 days of incubation.…”

Section: Biocompatibilitysupporting

confidence: 87%

“…In addition, Mo-Tao Zhu et al [64] explained that iron oxide nanoparticles induced endothelial system inflammation in three ways, which are escaping nanoparticles from phagocytosis and then interacting with the endothelial monolayer, then influencing the endothelial cells as free ions after dissolving of nanoparticles, and finally oxidative stress responses, as shown in Figure 10c. Another study by Ismat Ullah et al [34] showed that the co-doped nanofiber with traces of Fe 3+ ions have antibacterial activity against S. aureus and E. coli bacteria, and this is due to the interaction of irons ions with oxygen and forming of a complex. Overall, the proposed composite nanofiber opens the venous system for several applications such as multimodal biomedical imaging, catalysis, cancer therapy, targeted drug delivery, and diagnostics as a simple and economic nanomaterial.…”

Section: Biocompatibilitymentioning

confidence: 99%

“…For example, Ismat Ullah et al [33] synthesized a co-substitute of Sr 2+ /Fe 3+ in HAp NPs for various biomedical applications such as bone grafting, hyperthermia-based cancer treatment, and drug delivery. The impact of the co-doped traces of Sr/Fe in HAp showed an osteoblastic proliferation and osteogenic differentiation towards MC3T3-E1 cells and excellent antibacterial activity [34]. Moreover, the co-substitute Sr/Fe within HAp has multifunctional properties, improving the mechanical hardness, blood compatibility, adhesion, and proliferation [35].…”

Section: Introductionmentioning

confidence: 99%

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Development and Characterization of Cellulose/Iron Acetate Nanofibers for Bone Tissue Engineering Applications

et al. 2021

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In tissue engineering, design of biomaterial with a micro/nano structure is an essential step to mimic extracellular matrix (ECM) and to enhance biomineralization as well as cell biocompatibility. Composite polymeric nanofiber with iron particles/ions has an important role in biomineralization and collagen synthesis for bone tissue engineering. Herein, we report development of polymeric cellulose acetate (CA) nanofibers (17 wt.%) and traces of iron acetates salt (0.5 wt.%) within a polymeric solution to form electrospinning nanofibers mats with iron nanoparticles for bone tissue engineering applications. The resulting mats were characterized using field emission scanning electron microscopy (FESEM), transmission electron microscope (TEM), Fourier transform infrared (FTIR), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The resulted morphology indicated that the average diameter of CA decreased after addition of iron from (395 ± 30) to (266 ± 19) nm and had dense fiber distributions that match those of native ECM. Moreover, addition of iron acetate to CA solution resulted in mats that are thermally stable. The initial decomposition temperature was 300 °C of CA/Fe mat > 270 °C of pure CA. Furthermore, a superior apatite formation resulted in a biomineralization test after 3 days of immersion in stimulated environmental condition. In vitro cell culture experiments demonstrated that the CA/Fe mat was biocompatible to human fetal-osteoblast cells (hFOB) with the ability to support the cell attachment and proliferation. These findings suggest that doping traces of iron acetate has a promising role in composite mats designed for bone tissue engineering as simple and economically nanoscale materials. Furthermore, these biomaterials can be used in a potential future application such as drug delivery, cancer treatment, and antibacterial materials.

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“…Hydroxyapatite, obtained from various sources, including eggshells and bones of animals or codfish, is considered as the efficient carrier for the nanodrugs due to its biocompatibility and hydrophilic nature and has been extensively used in bone tissue regeneration applications (Wang et al, 2011;Luo et al, 2014;Ramani and Sastry, 2014;Kong et al, 2016;Ullah et al, 2018Ullah et al, , 2019aUllah et al, , 2020; Table 1). An earlier study reported the formation of calcium phosphate in the BNC matrix, which supported the adhesion and proliferation of osteoblast cells as well as the differentiation of mesenchymal stem cells into bone cells in the absence of external markers (Fang et al, 2009).…”

Section: Nanocellulose As a Matrix For Doping Of Minerals And Ceramicsmentioning

confidence: 99%

Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases

Khan

Siddique

Huanfei

et al. 2021

Front. Bioeng. Biotechnol.

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Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individual’s quality of life. Although bone has the innate ability to remodel and regenerate in case of small damage or a crack, a loss of a large volume of bone in case of a traumatic injury requires the restoration of bone function by adopting different biophysical approaches and chemotherapies as well as a surgical reconstruction. Compared to the biophysical and chemotherapeutic approaches, which may cause complications and bear side effects, the surgical reconstruction involves the implantation of external materials such as ceramics, metals, and different other materials as bone substitutes. Compared to the synthetic substitutes, the use of biomaterials could be an ideal choice for bone regeneration owing to their renewability, non-toxicity, and non-immunogenicity. Among the different types of biomaterials, nanocellulose-based materials are receiving tremendous attention in the medical field during recent years, which are used for scaffolding as well as regeneration. Nanocellulose not only serves as the matrix for the deposition of bioceramics, metallic nanoparticles, polymers, and different other materials to develop bone substitutes but also serves as the drug carrier for treating osteosarcomas. This review describes the natural sources and production of nanocellulose and discusses its important properties to justify its suitability in developing scaffolds for bone and cartilage regeneration and serve as the matrix for reinforcement of different materials and as a drug carrier for treating osteosarcomas. It discusses the potential health risks, immunogenicity, and biodegradation of nanocellulose in the human body.

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Impact of structural features of Sr/Fe co-doped HAp on the osteoblast proliferation and osteogenic differentiation for its application as a bone substitute

Cited by 57 publications

References 55 publications

Hydrothermally synthesis and characterization of HAp and Zr-doped HAp nanoparticles from bovine bone and zircon for photodynamic therapy

Hydrothermally synthesis and characterization of HAp and Zr-doped HAp nanoparticles from bovine bone and zircon for photodynamic therapy

Development and Characterization of Cellulose/Iron Acetate Nanofibers for Bone Tissue Engineering Applications

Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases

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