Impact of sublingual immunotherapy on seasonal asthma and skin reactivity in children allergic to <i>Parietaria</i> pollen treated with inhaled fluticasone propionate

Pajno, Giovanni Battista; Vita, Daniela De; Parmiani, S.; Caminiti, Lucia; Grutta, Stefania La; Barberio, G

doi:10.1111/j.1365-2222.2003.01809.x

Cited by 87 publications

(82 citation statements)

References 20 publications

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“…Wilson et al (1698) published a Cochrane Collaboration meta-analysis of SLIT in rhinitis and proposed that it was safe and effective. The Cochrane meta-analysis (1699) was followed by several studies which accorded with the results of the review (1103,(1700)(1701)(1702)(1703)(1704)(1705)(1706)(1707)(1708)(1709)(1710)(1711). Moreover, pivotal trials have been carried out and the results on over 600 patients showed convincingly that in grass pollen allergy, SLIT is safe and effective using tablets (1103,1712).…”

Section: Sublingual Immunotherapymentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,867

1,761

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Section: Sublingual Immunotherapymentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,867

1,761

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“…25,[34][35][36][37] Two placebocontrolled trials of olive and tree mix allergens with medium risk of bias that enrolled 70 and 98 children, respectively, demonstrated moderate to strong magnitude of effect for SLIT. 36,37 One study of dust mite immunotherapy in 58 children, with a low risk of bias and weak magnitude of effect, showed little improvement with SLIT compared with placebo.…”

Section: Conjunctivitismentioning

confidence: 99%

“…[25][26][27][28][29][32][33][34][35][36][37][38] One-half of the studies evaluated dust mite allergens. 25,26,[32][33][34]38 Risk of bias was low in 4 studies, 27,29,32,34 medium in 6 studies, 26,33,[35][36][37][38] and high in 2 studies. 25,28 Five studies demonstrated significant improvement in rhinitis/ rhinoconjunctivitis scores with SLIT, compared with placebo, with moderate to strong magnitudes of effect.…”

Section: Rhinitismentioning

confidence: 99%

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Allergen-Specific Immunotherapy for Pediatric Asthma and Rhinoconjunctivitis: A Systematic Review

Kim¹,

Lin²,

et al. 2013

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BACKGROUND AND OBJECTIVE: Subcutaneous immunotherapy (SCIT) is approved in the United States for the treatment of pediatric asthma and rhinitis; sublingual immunotherapy (SLIT) does not have regulatory approval but is used in clinical practice. The objective of this study was to systematically review the evidence regarding the efficacy and safety of SCIT and SLIT for the treatment of pediatric asthma and allergic rhinoconjunctivitis. METHODS:Two independent reviewers selected articles for inclusion, extracted data, and graded the strength of evidence for each clinical outcome. All studies were randomized controlled trials of children with allergic asthma or rhinoconjunctivitis treated with SCIT or an aqueous formulation of SLIT. Data sources were Medline, Embase, LILACS, CENTRAL, and the Cochrane Central Register of Controlled Trials through May 2012. RESULTS:In 13 trials, 920 children received SCIT or usual care; in 18 studies, 1583 children received SLIT or usual care. Three studies compared SCIT with SLIT head-to-head in 135 children. The strength of evidence is moderate that SCIT improves asthma and rhinitis symptoms and low that SCIT improves conjunctivitis symptoms and asthma medication scores. Strength of evidence is high that SLIT improves asthma symptoms and moderate that SLIT improves rhinitis and conjunctivitis symptoms and decreases medication usage. The evidence is low to support SCIT over SLIT for improving asthma or rhinitis symptoms or medication usage. Local reactions were frequent with SCIT and SLIT. There was 1 report of anaphylaxis with SCIT.CONCLUSIONS: Evidence supports the efficacy of both SCIT and SLIT for the treatment of asthma and rhinitis in children. Pediatrics

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“…For an individual allergic to particular pollen, the prediction of the start of that pollen's season can allow them to adjust their daily activities so as to avoid contact with the allergen (Peternel et al 2004), or to begin taking medication. Pollen count data is also important for research into allergic rhinitis, in particular for clinical trials into immunotherapy, vaccines and antihistamines, which rely on pollen counts to assess the efficacy of the drugs in relation to the severity of the allergenic stimulus (Keskin et al 2006;Pajno et al 2003;Mirone et al 2004). …”

Section: Introductionmentioning

confidence: 99%

Reproducibility between counts of airborne allergenic pollen from two cities in the East Midlands, UK

et al. 2009

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Historically in the East Midlands, UK, airborne pollen has been monitored in two cities, Derby and Leicester, situated 41 kilometres (25 miles) apart. The aim of the present study was to compare aerobiological data from both sites to determine if a forecast based on data from one site would be sufficient for both, and to address the wider issue of reproducibility between geographically separated sites.Pollen types recorded could be split into two groups according to annual abundance, maximum daily concentration and the number of high count days. Six taxa made up the abundant group; ash, birch, grass, oak, nettle-type and yew-type, representing 90 and 88% of the total air spora for Derby and Leicester respectively. Three consecutive years of grass and nettle pollen data are presented, supported by one year of abundant tree pollen data. There were highly significant positive correlations between the counts obtained. Line charts showing the average number of pollen grains m -3 air day -1 show similar trends, and Bland-Altman plots show little discrepancy between the amounts of pollen counted on any given day. Each day was classified according to the UK accepted threshold levels for grass. Weighted kappa statistics showed substantial or almost perfect agreement between the forecast classifications. With the caveat that this would not apply in a region with restrictions to air flow such as a mountain range, or with extreme fluctuations such as a coastline site, this study suggests that data from a single site is suitable for forecasting a distance of up to 41 km.Keywords Pollen forecast, hayfever, aerobiology, allergy 1 Reproducibility between counts of airborne allergenic pollen from two cities in the East Midlands, UK. AbstractHistorically in the East Midlands, UK, airborne pollen has been monitored in two cities, Derby and Leicester, situated 41 kilometres (25 miles) apart. The aim of the present study was to compare aerobiological data from both sites to determine if a forecast based on data from one site would be sufficient for both, and to address the wider issue of reproducibility between geographically separated sites.Pollen types recorded could be split into two groups according to annual abundance, maximum daily concentration and the number of high count days. Six taxa made up the abundant group; ash, birch, grass, oak, nettle-type and yew-type, representing 90 and 88% of the total air spora for Derby and Leicester respectively.Three consecutive years of grass and nettle pollen data are presented, supported by one year of abundant tree pollen data. There were highly significant positive correlations between the counts obtained. Line charts showing the average number of pollen grains m -3 air day -1 show similar trends, and Bland-Altman plots show little discrepancy between the amounts of pollen counted on any given day. Each day was classified according to the UK accepted threshold levels for grass. Weighted kappa statistics showed substantial or almost perfect agreement between the forecast classif...

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Impact of sublingual immunotherapy on seasonal asthma and skin reactivity in children allergic to Parietaria pollen treated with inhaled fluticasone propionate

Cited by 87 publications

References 20 publications

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Allergen-Specific Immunotherapy for Pediatric Asthma and Rhinoconjunctivitis: A Systematic Review

Reproducibility between counts of airborne allergenic pollen from two cities in the East Midlands, UK

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