Impact of surface defects in electron beam evaporated ZnO thin films on FET biosensing characteristics towards reliable PSA detection

Chakraborty, Bidesh; Saha, Rajib; Chattopadhyay, Sanatan; De, D. K.; Das, Ruma; Mukhopadhyay, Mrinmay K.; Palit, Mainak; RoyChaudhuri, C.

doi:10.1016/j.apsusc.2020.147895

Cited by 23 publications

(12 citation statements)

References 41 publications

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“…Beyond the electrochemical biosensors, SAMs play a significant role at the electronic interfaces across a broad range of devices, such as organic thin-film transistors (OTFTs), field-effect transistor (FET) biosensors, and other organic electronic devices. − In OTFTs, for example, SAMs often serve as an active semiconductor layer, offering their ability to modify gate dielectrics and thus control the charge-carrier injection rates. For FET biosensors (in the same category as electrochemical biosensors), SAMs also serve as a blocking layer for antifouling purposes that could decrease the nonspecific adsorption of proteins and other interfering molecules , and improve the signal-to-noise ratio of electrochemical measurements via the extension of the electrode–electrolyte dielectric distance. Given this, we believe that our survey here of SAMs for E-AB sensor application would provide a guideline to rationally modify the interface with a desirable performance from a molecular level.…”

Section: Discussionmentioning

confidence: 99%

Exploring End-Group Effect of Alkanethiol Self-Assembled Monolayers on Electrochemical Aptamer-Based Sensors in Biological Fluids

Wang

Zhang

et al. 2021

Anal. Chem.

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The continuous, real-time monitoring of specific analytes in situ in biological fluids would provide personalized, high-precision pharmacokinetic information for the goal of precision medicine. Due to their conformationally linked signaling mechanism, electrochemical aptamer-based (E-AB) sensors are promising candidates for accurate measurements in such complex media. They suffer, however, from severe baseline drift when interrogated continuously and in real-time manner. In response, here, we investigate a couple of self-assembled monolayers in the application of E-AB sensors, achieving the improvement of their baseline stability and simultaneous modulation of sensor performance, e.g., target affinity and specificity.

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Section: Discussionmentioning

confidence: 99%

Exploring End-Group Effect of Alkanethiol Self-Assembled Monolayers on Electrochemical Aptamer-Based Sensors in Biological Fluids

Wang

Zhang

et al. 2021

Anal. Chem.

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“…The schematic of the sensor and the process flow of fabrication are depicted in Figure 1a,b. 29 Functionalization of ZnO. For proper antibody immobilization, the silanization process was performed followed by cross-linker attachment.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…This method ensures repeatability of measurements. The schematic of the sensor and the process flow of fabrication are depicted in Figure a,b …”

Section: Methodsmentioning

confidence: 99%

Competitive Impedance Spectroscopy in a Schottky-Contacted ZnO Nanorod Structure for Ultrasensitive and Specific Biosensing in a Physiological Analyte

et al. 2022

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To enable detection and discovery of biomarkers, development of label-free, ultrasensitive, and specific sensors is the need of the hour. For addressing this requirement, here, a Schottky-contacted ZnO nanorod biosensor has been demonstrated, which explores the interplay between Schottky junction capacitance and solution resistance, resulting in an interesting sensing principle of competitive impedance spectroscopy. When the transition of dominating impedance occurs from solution resistance to junction capacitance, a notch or a peak appears in the impedance response at a particular frequency (referred to as the corner frequency) depending on the charge of the target molecule. The appearance of the peak or notch acts like an electronic label for selectivity since it is visible only for target molecules even at ultralow concentrations in the physiological analyte, where the magnitude of impedance change overlaps with that for nonspecific molecules. This phenomenon has been successfully applied for the positively charged vascular endothelial growth factor (VEGF) and the negatively charged hepatitis B surface antigen (HBsAg), where the shifts in the higher corner frequencies for 1 aM concentration of the target molecules have been observed to be more than 3 times the changes in the impedance magnitude. Further, the area of the ZnO nanorods was segmented into two zones corresponding to the lower and higher concentration regimes, thereby expanding the dynamic range. To summarize, an ultralow detection limit of 1 aM with a dynamic range up to 1 pM was achieved for VEGF and HBsAg, which is 4 orders of magnitude and 20 times lower than their most sensitive label-free reports, respectively.

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“…The photoresist detector with surface arrayed electrodes is sensitive to the grain boundary defects . In order to investigate the behavior of defects at high temperature, the photoresist detectors were prepared and the measurement system was assembled as in Figure S18a.…”

Section: Crystal Structure Of the Hybrid Thin Filmsmentioning

confidence: 99%

“…The photoresist detector with surface arrayed electrodes is sensitive to the grain boundary defects. 36 In order to investigate the behavior of defects at high temperature, the photoresist detectors were prepared and the measurement system was assembled as in Figure S18a. The dark current results show that the TrMA device exhibits a relatively stable current, rather than the 5-fold increase in the control device, which results from the thermally induced traps (Figure S18b).…”

mentioning

confidence: 99%

Rotatable Skeleton for the Alleviation of Thermally Accumulated Defects in Inorganic Perovskite Solar Cells

Xiong

Deng

et al. 2023

ACS Energy Lett.

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The stability of perovskite solar cells has been identified as the bottleneck for their industrialization. With an aim at tackling this challenge, we self-synthesize a thus-far unreported linearly rotatable structure perovskite, i.e., TrMAPbX 3 (X = Br, I). The as-prepared hybrid perovskite is observed to demonstrate extremely high stability during device operation with high electric field strength and high temperature, which is associated with the good lattice-matching heterojunction structure between the linearly rotatable TrMAPbX 3 structure and 3D inorganic perovskite domain within a wide temperature range. The tight-fitting interface structure is devoted to inhibiting the accumulation of vacancy defects during device operation, which further avoids the δ-phase transition and charge transport resistance. Accordingly, we realize a CsPbI 3−x Br x inorganic perovskite-based solar cell with power conversion efficiency (PCE) of 20.59%, extending the remarkably high thermal stability to 192 h (85 °C and relative humidity of 25%) and 3055 h (25 °C and relative humidity of 25%).

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Impact of surface defects in electron beam evaporated ZnO thin films on FET biosensing characteristics towards reliable PSA detection

Cited by 23 publications

References 41 publications

Exploring End-Group Effect of Alkanethiol Self-Assembled Monolayers on Electrochemical Aptamer-Based Sensors in Biological Fluids

Exploring End-Group Effect of Alkanethiol Self-Assembled Monolayers on Electrochemical Aptamer-Based Sensors in Biological Fluids

Competitive Impedance Spectroscopy in a Schottky-Contacted ZnO Nanorod Structure for Ultrasensitive and Specific Biosensing in a Physiological Analyte

Rotatable Skeleton for the Alleviation of Thermally Accumulated Defects in Inorganic Perovskite Solar Cells

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